Chemical Characterization of Aerosol Particles Using On-Chip Photonic Cavity Enhanced Spectroscopy

Singh, Ramandeep; Ma, Danhao; Kimerling, Lionel C.; Agarwal, Anuradha M.; Anthony, Brian W.

doi:10.1021/acssensors.8b00587

Cited by 21 publications

(15 citation statements)

References 30 publications

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“… 21 The SARS-CoV-2 particles in aerosol can be characterized with on-chip spectroscopy using a photonic cavity enhanced silicon nitride (Si 3 N 4 ) racetrack resonator-based sensor. 22 The electrochemical biosensor based on surface imprinted polymers and graphene oxide composites can identify isolated virus, which has a limit of detection (LoD) similar to RT-PCR for Zika virus detection. 23 Solid-state micro- and nanopores monitor viral particles in the air by cross-pore ionic current.…”

Section: Diagnostic Approaches To Covid-19mentioning

confidence: 99%

Current and Perspective Diagnostic Techniques for COVID-19

et al. 2020

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Since late December 2019, the coronavirus pandemic (COVID-19; previously known as 2019-nCoV) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been surging rapidly around the world. With more than 1,700,000 confirmed cases, the world faces an unprecedented economic, social, and health impact. The early, rapid, sensitive, and accurate diagnosis of viral infection provides rapid responses for public health surveillance, prevention, and control of contagious diffusion. More than 30% of the confirmed cases are asymptomatic, and the high false-negative rate (FNR) of a single assay requires the development of novel diagnostic techniques, combinative approaches, sampling from different locations, and consecutive detection. The recurrence of discharged patients indicates the need for long-term monitoring and tracking. Diagnostic and therapeutic methods are evolving with a deeper understanding of virus pathology and the potential for relapse. In this Review, a comprehensive summary and comparison of different SARS-CoV-2 diagnostic methods are provided for researchers and clinicians to develop appropriate strategies for the timely and effective detection of SARS-CoV-2. The survey of current biosensors and diagnostic devices for viral nucleic acids, proteins, and particles and chest tomography will provide insight into the development of novel perspective techniques for the diagnosis of COVID-19.

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Section: Diagnostic Approaches To Covid-19mentioning

confidence: 99%

Current and Perspective Diagnostic Techniques for COVID-19

et al. 2020

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“…Its sensitivity depends on the optical depth of the analyte, which can be strongly enhanced by enclosing it in an optical cavity. Cavity enhanced absorption spectroscopy using cavity ring-downs [4,5], mode width [6], or more elaborate techniques like noise-immune cavity-enhanced optical heterodyne molecular spectroscopy (NICE-OHMS) [7] have found applications in many fields of research, in particular in gas spectroscopy [7], in analysing atmosphere [8] and chemical compositions [9][10][11], or in medical diagnosis [12]. Whilst conventional macroscopic Fabry-Perot cavities can be used to reach extreme sensitivity (analyte absorption coefficients of < 1 × 10 −9 cm −1 [5]), their susceptibility to ambient disturbance and their meter-scale size limits them to laboratory-based setups and requires large analyte volumes.…”

Section: Introductionmentioning

confidence: 99%

A fiber Fabry-Perot cavity based spectroscopic gas sensor

Saavedra,

Pandey,

Alt

et al. 2022

Preprint

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Optical spectroscopic sensors are powerful tools for analysing gas mixtures in industrial and scientific applications. Whilst highly sensitive spectrometers tend to have a large footprint, miniaturized optical devices usually lack sensitivity or wideband spectroscopic coverage. By employing a widely tunable, passively stable fiber Fabry-Perot cavity (FFPC), we demonstrate an absorption spectroscopic device that continuously samples over several tens of terahertz. Both broadband scans using cavity mode width spectroscopy to identify the spectral fingerprints of analytes and a fast, low-noise scan method for single absorption features to determine concentrations are exemplary demonstrated for the oxygen A-band. The novel scan method uses an injected modulation signal in a Pound-Drever-Hall feedback loop together with a lock-in measurement to reject noise at other frequencies. The FFPC-based approach provides a directly fiber coupled, extremely miniaturized, light-weight and robust platform for analyzing small analyte volumes that can straightforwardly be extended to sensing at different wavelength ranges, liquid analytes and other spectroscopic techniques with only little adjustments of the device platform.

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“…Silicon photonics promises highly effective, low-cost, and scalable solutions to miniaturize electronic and photonic systems [1][2][3], enabling on-chip spectroscopic sensing and imaging techniques in the fields of medicine and biology [4][5][6], for examining the behavior of biomolecular species and living cells. Among these techniques, the most common are fluorescence imaging/microscopy, infra-red (IR) spectroscopy, and Raman spectroscopy [7][8][9][10][11][12][13]. Fluorescence imaging/microscopy is a powerful tool for biomedical research because it provides very high sensitivity and specificity for cellular activity detection, making it the gold standard.…”

Section: Introductionmentioning

confidence: 99%

Inverse Design of Photonic Metasurface Gratings for Beam Collimation in Opto-fluidic Sensing

Singh¹,

Nie²,

Agarwal³

et al. 2019

Preprint

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Metasurfaces provide the disruptive technology enabling miniaturization of complex cascades of optical elements on a plane. We leverage the benefits of such a surface to develop a planar integrated photonic beam collimator for on-chip optofluidic sensing applications. While most of the current work focuses on miniaturizing the optical "detection" hardware, little attention is given to develop on-chip hardware for optical "excitation". In this manuscript, we propose a flat metasurface for beam collimation in optofluidic applications. We implement an inverse design approach to optimize the metasurface using gradient descent method and experimentally compare its characteristics with conventional binary grating-based photonic beam diffractors. The proposed metasurface can enhance the illumination efficiency almost two times in on-chip applications such as fluorescence imaging, Raman and IR spectroscopy and can enable multiplexing of light sources for high throughput biosensing.

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Chemical Characterization of Aerosol Particles Using On-Chip Photonic Cavity Enhanced Spectroscopy

Cited by 21 publications

References 30 publications

Current and Perspective Diagnostic Techniques for COVID-19

Current and Perspective Diagnostic Techniques for COVID-19

A fiber Fabry-Perot cavity based spectroscopic gas sensor

Inverse Design of Photonic Metasurface Gratings for Beam Collimation in Opto-fluidic Sensing

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