Chemical Characterization and Cytotoxic/Antibacterial Effects of Nine Iranian Propolis Extracts on Human Fibroblast Cells and Oral Bacteria

Yazdanian, Mohsen; Motallaei, Mohammad Nima; Tahmasebi, Elahe; Tebyanian, Hamid; Alam, Mostafa; Abbasi, Kamyar; Seifalian, Alexander M.; Ranjbar, Reza; Yazdanian, Alireza; Hosseini, Hamideh Mahmoodzadeh; Moghaddam, Mehrdad Moosazadeh

doi:10.1155/2022/6574997

Cited by 18 publications

(15 citation statements)

References 34 publications

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“…Nanomaterials are used as either antimicrobials for their inherent antimicrobial properties or drug delivery systems specifically designed to have affinity to dental surfaces [31]. Silver (Ag), copper oxide (CuO, Cu 2 O, Cu 2 O 3 , and CuO 2 ), zinc oxide (ZnO), titanium oxide (TiO, TiO 2 , and Ti 2 O 3 ), graphene (an allotrope of carbon), quaternary ammonium polyethyleneimine (QA-PEI), chitosan (CH), and silica (SiO 2 ) nanoparticles are examples of numerous nanomaterials that can control biofilm formation [29,[32][33][34][35][36]. Among all, silver nitrate (AgNO 3 ) and silver nanoparticles (AgNPs) are indicated as specific metal nanomaterials with one of the highest capacities to control the oral biofilm [37].…”

Section: Chemical Antibiofilm Materialsmentioning

confidence: 99%

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Moghaddam

Ranjbar

Yazdanian

et al. 2022

BioMed Research International

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Herbal and chemical products are used for oral care and biofilm treatment and also have been reported to be controversial in the massive trials conducted in this regard. The present review is aimed at evaluating the potential of relevant herbal and chemical products and comparing their outcomes to conventional oral care products and summarizing the current state of evidence of the antibiofilm properties of different products by evaluating studies from the past eleven years. Chlorhexidine gluconate (CHX), essential oils (EOs), and acetylpyridinium chloride were, respectively, the most commonly studied agents in the included studies. As confirmed by all systematic reviews, CHX and EO significantly control the plaque formation and gingival indices. Fluoride is another interesting reagent in oral care products that has shown promising results of oral health improvement, but the evidence quality needs to be refined. The synergy between natural plants and chemical products should be targeted in the future to accede to the formation of new, efficient, and healthy anticaries strategies. Moreover, to discover their biofilm-interfering or biofilm-inhibiting activities, effective clinical trials are needed. In this review article, therapeutic applications of herbal/chemical materials in oral biofilm infections are discussed in recent years (2010-2022).

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Section: Chemical Antibiofilm Materialsmentioning

confidence: 99%

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Moghaddam

Ranjbar

Yazdanian

et al. 2022

BioMed Research International

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“…Dental procedures lead to the dissemination of microorganisms in the aerosol in the dental office. Some research showed mouth wash rinse such as chlorhexidine, essential oils, cetylpyridinium chloride, and herbal products to reduce the microorganisms in dental office aerosol [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]. Commercially available mouthwashes, such as 0.05% cetylpyridinium chloride CPC utilized as a pre-procedural mouth rinse, were equally beneficial, as CHX, to lower the incidence of bacteria produced during the ultrasonic scaling [39], [40], [44], [49], [50], [51], [52].…”

Section: Mouth Washmentioning

confidence: 99%

COVID-19 Risk Management in Dental Offices: A Review Article

Aghili¹,

Pourzal²,

Mosaddad³

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: As all the dental staff, including nurses and practitioners, are exposed to various routes of contamination due to the novel COVID-19 virus, which is still unknown to the scientific world, developing strategies to reduce the risk of transmission and decontaminate surfaces in a dental office would be of high importance. Although there is still insufficient data on managing this virus in dental offices, several studies have suggested protocols for improving care. AIM: This study aimed to review present investigations and reach a conclusion on what we know and need to know to combat this virus. MATERIALS AND METHODS: In this review, Scopus, PubMed, and MEDLINE databases were searched using the keywords “COVID-19,” “SARS-CoV-2,” “Medical Disinfectants,” “Personal Protective Equipment’s,” and “Surface Decontamination.” Articles were reviewed, and finally, relevant articles published during 2000–2022 were included in the final paper. RESULTS: The present research concluded that using a combination of the face shield and N95 masks protected the eyes, nose, and mouth. To have more efficient protection, water-resistant long-sleeved gowns and gloves were highly suggested. To overcome aerosols, high-performance air filters and ultraviolet were found quite effective. Allowing the patient to use antiseptic mouthwash before starting the treatment could reduce oral microorganisms and the following airborne contamination. CONCLUSION: This review has gathered all available data regarding dentistry and COVID-19 in order to conclude what has been achieved yet in the prevention of this virus through dental offices; however, more investigations are needed to have a definitive protocol against the virus.

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“…Children and adults sufer from pain, structural damage to their teeth, and eventual tooth loss due to the loss of mineralized tissues. Lactobacillus is the most common bacteria that cause periodontal diseases and cause infammation, and infection [6][7][8][9][10][11]. An arsenal of redox potentials is found in plant extracts.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Cytotoxicity and Antimicrobial of Synthesized CuO NPs from Propolis on HEK‐293 Cells and Lactobacillus acidophilus

Hajizadeh

Babapour

Harzandi

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. Drug resistance is currently possible anywhere in the world. Due to the discovery of antimicrobials, medicine, and health have made tremendous advances over the past several decades. Aim. This research evaluated the antimicrobial and cytotoxicity effects of green synthesis of copper oxide nanoparticles (CuO NPs) on Lactobacillus acidophilus and human embryonic kidney 293 cells (HEK). Method and Materials. Propolis was sampled and extracted. Green synthesis of CuO NPs was synthesized and characterized using SEM, TEM, DLS, BET, and zeta potential methods. L. acidophilus (ATCC 4356) was used, and the antimicrobial tests were carried out at different concentrations (10≥ mg/ml). Moreover, the cytotoxicity was evaluated using an MTT assay on human embryonic kidney 293 cells (HEK). Results. Synthesized CuO NPs using propolis extracts from Khalkhal (sample 1) and Gillan (sample 2) showed −13.2 and −14.4 mV, respectively. The hydrodynamic sizes of well-dispersed samples 1 and 2 were 3124.9 nm and 1726.7 nm, respectively. According to BET analysis, samples 1 and 2 had 5.37 and 8.45 m2/g surface area, respectively. The surface area was decreased due to the addition of propolis extract, and the pore size was increased. CuO NPs of samples 1 and 2 were visible on SEM images with diameters ranging from 75 to 145 nm and 120 to 155 nm, respectively. Based on TEM analysis, the size of CuO particles was increased in samples 1 and 2. CuO NPs particles had narrow size distributions with evenly dispersed NPs on all sides. The cell viability of the CuO NPs of samples 1 and 2 after 24, 48, and 72 hours was greater than 50%. As a result of the MIC and MBC tests, it was determined that samples 1 and 2 had the same effect against L. acidophilus (0.0024 mg/ml). Biofilm formation and degradation of sample 1 were more efficient against L. acidophilus. Conclusion. There was no evidence of cytotoxicity in the samples. In addition, results showed that the green synthesized CuO NPs from Khalkhal propolis were effective against L. acidophilus. Thus, the green synthesized CuO NPs from Khalkhal propolis were the best candidates for clinical application.

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Chemical Characterization and Cytotoxic/Antibacterial Effects of Nine Iranian Propolis Extracts on Human Fibroblast Cells and Oral Bacteria

Cited by 18 publications

References 34 publications

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

COVID-19 Risk Management in Dental Offices: A Review Article

The Effect of Cytotoxicity and Antimicrobial of Synthesized CuO NPs from Propolis on HEK‐293 Cells and Lactobacillus acidophilus

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