Chemical and morphological characterization of &lt;em&gt;Allium tuncelianum (Amaryllidaceae)&lt;/em&gt; and its antioxidant and anticholinesterase potentials

Karakaya, Songül; Ekşi, Gülnur; Koca, Mehmet; Demirci, Betül; Kaymak, Haluk Çağlar; Kaplan, Mehmet Emin; Aksakal, Özkan

doi:10.3989/ajbm.2523

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…In reference to all the compiled literature, we observed that the IC 50 results were presented in several formats, in particular to the units of measurement. Among the units that were reported included mg gallic acid equivalents/g [ 64 , 76 ], percentage [ 65 , 74 ], mg/mL or mg/L [ 26 , 67 , 68 , 73 , 75 ], μm [ 69 ], and µg/mL [ 18 , 70 , 71 , 72 ]. This diversity, however, was considered troublesome because direct comparison among studies with different measurement units is not possible without conversion.…”

Section: Discussionmentioning

confidence: 99%

Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review

2021

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Despite the improvements in life expectancy, neurodegenerative conditions have arguably become the most dreaded maladies of older people. The neuroprotective and anti-ageing potentials of essential oils (EOs) are widely evaluated around the globe. The objective of this review is to analyse the effectiveness of EOs as neuroprotective remedies among the four common age-related neurodegenerative diseases. The literature was extracted from three databases (PubMed, Web of Science and Google Scholar) between the years of 2010 to 2020 using the medical subject heading (MeSH) terms “essential oil”, crossed with “Alzheimer’s disease (AD)”, “Huntington’s disease (HD)”, “Parkinson’s disease (PD)” or “amyotrophic lateral sclerosis (ALS)”. Eighty three percent (83%) of the studies were focused on AD, while another 12% focused on PD. No classifiable study was recorded on HD or ALS. EO from Salvia officinalis has been recorded as one of the most effective acetylcholinesterase and butyrylcholinesterase inhibitors. However, only Cinnamomum sp. has been assessed for its effectiveness in both AD and PD. Our review provided useful evidence on EOs as potential neuroprotective remedies for age-related neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review

2021

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“…The pathophysiology of AD is not yet completely resolved, however aging is currently recognized as a key factor that activates several neurodegenerative pathways resulting in loss of neuronal cells (Karakaya et al, 2019a;Magalingam et al, 2018). Hallmarks of AD include β-amyloid (Aβ) proteins aggregation to senile plaques, τ-protein hyperphosphorylation, neurofibrillary tangles, low level of ACh, neuroinflammation, dendritic pathology, etc.…”

Section: Description Symptoms and Pathophysiology Of Admentioning

confidence: 99%

Enzyme inhibitors as controllers of neurodegenerative diseases: An update of in vitro effects of medicinal plants

Aradski-Alimpić¹,

Pavlović²,

Janković³

et al. 2021

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Considering the increase of the elderly population in recent years, the growing prevalence of age-related neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), has become one of the leading healthcare problems. Currently, available therapies for AD and PD are still limited, while medicinal plants used in traditional medicine for millennia can inhibit enzymes involved in the neurodegeneration processes in AD (acetylcholinesterase, AChE, and butyrylcholinesterase, BChE) and PD (tyrosinase, TYR), hence their inhibiting effects are continuously being investigated especially in the past decade. This study was aimed to review data on medicinal plants as potential cholinesterases and TYR inhibitors reported from January 2018 until May 2021. The literature search was performed using several online bibliographical databases (Scopus, Web of Science, Science Direct, Google Scholar, PubMed, and ResearchGate) and two websites. Data analysis showed that the highest number of representatives belongs to Lamiaceae family (up to 20 %), followed by Asteraceae. Almost half of the tested samples were prepared from whole plant/aerial plant parts followed by leaves. The most frequently tested preparations were methanolic extracts (about 25 % of the samples examined). Additionally, synergistic interactions between different herbs and/or isolated compounds were considered as a promising strategy for further research. The presented data showed that medicinal plants preparations represent an unlimited source for research of new and more effective AD and PD treatments. This review will provide a useful starting point for further research on this topic.

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“…[3][4][5][6] Species number is more than 950 distributed in Northern hemisphere except A. synnotii G.Don. [7][8][9][10] It has 15 subgenera and 80 sections. [3] Turkey is one of the genetic center for the genus with ca.…”

Section: Introductionmentioning

confidence: 99%

“…Allium L. (Amaryllidaceae) is a taxonomically complicated and highly diverse genus [3–6] . Species number is more than 950 distributed in Northern hemisphere except A. synnotii G.Don [7–10] . It has 15 subgenera and 80 sections [3] .…”

Section: Introductionmentioning

confidence: 99%

Contributions of Chemical Content and Biological Activity to Plant Taxonomy Based on the FourAlliumL. Taxa (Sect.Cupanioscordum‐ Amaryllidaceae)

Ekşi

Çiftçi

Demırcı

et al. 2023

Chemistry & Biodiversity

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Garlic and onions are used as food and for medicinal purposes worldwide. Allium L. species are rich in bioactive organosulphur compounds that exhibit many biological activities like anticancer, antimicrobial, antihypertensive, antidiabetic activities. In this study, macro‐ and micromorphological characteristics of four Allium taxa were examined and the results suggested that A. callimischon subsp. haemostictum was the outgroup to sect. Cupanioscordum. Also, for the genus Allium, which is a taxonomically difficult genus, the hypothesis that chemical content and bioactivity can also be used taxonomically in addition to micro and macromorphological characters has been questioned. The bulb extract was analyzed to determine their volatile compositions and anticancer activities against human breast cancer, human cervical cancer, and rat glioma cells for the first time in the literature. To detect the volatiles, the Head Space‐Solid Phase Micro Extraction method was used followed by Gas Chromatography‐Mass Spectrometry. The main compounds were found as dimethyl disulfide that (36.9 %, 63.8 %, 81.9 %, 12.2 %) and methyl (methylthio)‐methyl disulfide (10.8 %, 6.9 %, 14.9 %, 60.0 %) for A. peroninianum, A. hirtovaginatum and A. callidyction, respectively. Additionally, methyl‐trans‐propenyl disulfide is detected for A. peroniniaum (36 %). As a result, all extracts have shown significant efficacy against MCF‐7 cells depending on applied concentrations. The treatment of MCF‐7 cells for 24 h with 10, 50, 200, or 400 μg/mL ethanolic bulb extract of four Allium species resulted in DNA synthesis inhibition. Survival rates for A. peroninianum was 51.3 %, 49.7 %, 42.2 %, 42.0 %, for A. callimischon subsp. haemostictum 62.5 %, 63.0 %, 23.2 %, 22 %, for A. hirtovaginatum 52.9 %, 42.2 %, 42.4 %, 39.9 %, for A. callidyction 51.8 %, 43.2 %, 39.1 %, 31.3 %, for cisplatin 59.6 %, 59.9 %, 50,9 %, 48.2 %, respectively. Moreover, taxonomic evaluation according to biochemical compounds and bioactivities is almost in agreement with that made according to micro and macromorphological characters.

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Chemical and morphological characterization of <em>Allium tuncelianum (Amaryllidaceae)</em> and its antioxidant and anticholinesterase potentials

Cited by 7 publications

References 26 publications

Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review

Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review

Enzyme inhibitors as controllers of neurodegenerative diseases: An update of in vitro effects of medicinal plants

Contributions of Chemical Content and Biological Activity to Plant Taxonomy Based on the FourAlliumL. Taxa (Sect.Cupanioscordum‐ Amaryllidaceae)

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