Chemical and cytotoxic analyses of brown Brazilian propolis ( Apis mellifera ) and its in vitro activity against itraconazole-resistant  Sporothrix brasiliensis

Waller, Stefanie Bressan; Peter, Cristina Mendes; Hoffmann, Jéssica Fernanda; Picoli, Tony; Osório, Luíza da Gama; Chaves, Fábio Clasen; Zani, João Luíz; Faria, Renata Osório de; Mello, João Roberto Braga de; Meireles, Mário Carlos Araújo

doi:10.1016/j.micpath.2017.02.022

Cited by 22 publications

(21 citation statements)

References 27 publications

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“…Acredita-se que a ação antimicrobiana possa ser decorrente da alteração de diversas enzimas, incluindo aquelas envolvidas com a produção de energia e a síntese de componentes estruturais. Em geral, o estudo do mecanismo de ação dos óleos essenciais tem usado metodologia comum na tentativa de ilustrar os efeitos prejudiciais que ocorrem na membrana celular (WALLER et al, 2017)…”

Section: Resultsunclassified

“…A Esporotricose pode acometer pessoas de ambos os sexos, de qualquer faixa etária ou raça, independente de fatores individuais predisponentes. Por ser contagiosa e o tratamento ser longo e pouco conhecido, os tutores abandonam os animais acometidos, contribuindo assim para disseminação do patógeno no ambiente e assim havendo aumentado de casos (WALLER et al, 2017) O tratamento recomendado tanto para seres humanos quanto para animais é o uso do antifúngico Itraconazol, devido a sua eficiência e segurança terapêutica já conhecida. Entretanto, nos últimos anos o surgimento de resistência ao antifúngico recomendado tornou o controle da doença mais difícil (CHAVES et al, 2012;RODRIGUES et al, 2012).…”

Section: Introductionunclassified

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Potencial Antifúngico De Óleo Essencial Extraídos De Folhas De Araçá (Psidium Guineense Sw.) Contra Sporothrixsp.

Vaz¹,

Costa²,

M.³

et al. 2017

Anais Do 5º Encontro Brasileiro Para Inovação Terapêutica

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Section: Resultsunclassified

Section: Introductionunclassified

Potencial Antifúngico De Óleo Essencial Extraídos De Folhas De Araçá (Psidium Guineense Sw.) Contra Sporothrixsp.

Vaz¹,

Costa²,

M.³

et al. 2017

Anais Do 5º Encontro Brasileiro Para Inovação Terapêutica

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“…On the other hand, the itraconazoleresistant isolates recognized in S120 and S146 were sensitive to 3 and 4, but only S146 was sensitive to 1 and was inhibited to 2 and 5. The ability to resist to the action of itraconazole was also showed in S. brasiliensis isolated from feline and canine sporotrichosis (Waller et al, 2017), as well as in other Sporothrix species, such as S. albicans and S. luriei from feline and canine cases, respectively (Oliveira et al, 2011) and S. globosa from human sporotrichosis (Fischman Gompertz et al, 2016). In our study, the activity profile of POA derivatives in two itraconazole-resistant isolates (S120 and S146) shed light on the activity of these molecules.…”

Section: Discussionmentioning

confidence: 97%

Anti-Sporothrix brasiliensis activity of different pyrazinoic acid prodrugs: a repurposing evaluation

Waller

Nakasu

Silva

et al. 2018

Braz. J. Pharm. Sci.

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From drug repurposing studies, this work aimed to evaluate the activity of different pyrazinoic acid (POA) derivatives against Sporothrix brasiliensis. The POA esters were prepared and characterized as previously reported by classical esterification reactions, with good to excellent yields. Sporothrix brasiliensis isolates from cats (n=6) and standard strains of S. brasiliensis and S. schenckii were used to assess the antifungal activity of the POA derivatives through broth microdilution assay (CLSI M38-A2). Among the tested compounds, molecules 3 and 4 showed fungistatic and fungicidal activities against all Sporothrix spp. strains, and the obtained MIC and MFC values ranged from 2.12 to 4.24 mg/mL and from 1.29 to 5.15 mg/mL, respectively. Compound 2 and 5 were active as in vitro inhibitors of fungal growth, but showed weak fungicidal activity, while molecules 1 and POA itself were inactive. The results suggest the activity of POA derivatives against Sporothrix spp. may be dependent on the lipophilicity. In addition, the antifungal susceptibility of the isolates to itraconazole was performed, showing that two Sporothrix isolates from cats were itraconazole-resistant. Compounds 3 and 4 were also active against these itraconazole-resistant isolates, indicating a possible alternative route to the standard mode of action of itraconazole.

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“…Brown propolis is found in several Brazilian and Cuban regions . Its botanic source is highly variable, originating from Luehea sp.…”

Section: Propolismentioning

confidence: 99%

Propolis: types, composition, biological activities, and veterinary product patent prospecting

et al. 2019

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Propolis is a resinous substance composed of a mixture of different plant parts and molecules secreted by bees. Chemically, it is defined as a complex matrix containing biologically active molecules with antibacterial, antifungal, antiviral, antiparasitic, hepatoprotective, and immunomodulatory activities. It is widely employed in cosmetic formulations and pharmaceutical products and is one of the most widely used natural products. However, the effects and strength of these biological activities depend on the chemical profile and composition of each propolis type. This composition is associated with the diversity of local flora, the place and period of collection, and the genetics of the bees. In this context, the objective of this review was to investigate the biological, chemical, and microbiological properties of propolis. A technological prospection was also performed on patents for products designed to be used in animal health. Our investigation shows that the literature contains diverse studies dedicated to comparing and describing the composition and therapeutic properties of propolis. These studies demonstrate the potential biological use of propolis in veterinary medicine, showing the applications of propolis extracts in different formulations. However, there are a low number of propolis‐based veterinary products with a registered patent. Thus, the development of products based on propolis is a promising market to be exploited. © 2019 Society of Chemical Industry

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Chemical and cytotoxic analyses of brown Brazilian propolis ( Apis mellifera ) and its in vitro activity against itraconazole-resistant Sporothrix brasiliensis

Cited by 22 publications

References 27 publications

Potencial Antifúngico De Óleo Essencial Extraídos De Folhas De Araçá (Psidium Guineense Sw.) Contra Sporothrixsp.

Potencial Antifúngico De Óleo Essencial Extraídos De Folhas De Araçá (Psidium Guineense Sw.) Contra Sporothrixsp.

Anti-Sporothrix brasiliensis activity of different pyrazinoic acid prodrugs: a repurposing evaluation

Propolis: types, composition, biological activities, and veterinary product patent prospecting

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