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From drug repurposing studies, this work aimed to evaluate the activity of different pyrazinoic acid (POA) derivatives against Sporothrix brasiliensis. The POA esters were prepared and characterized as previously reported by classical esterification reactions, with good to excellent yields. Sporothrix brasiliensis isolates from cats (n=6) and standard strains of S. brasiliensis and S. schenckii were used to assess the antifungal activity of the POA derivatives through broth microdilution assay (CLSI M38-A2). Among the tested compounds, molecules 3 and 4 showed fungistatic and fungicidal activities against all Sporothrix spp. strains, and the obtained MIC and MFC values ranged from 2.12 to 4.24 mg/mL and from 1.29 to 5.15 mg/mL, respectively. Compound 2 and 5 were active as in vitro inhibitors of fungal growth, but showed weak fungicidal activity, while molecules 1 and POA itself were inactive. The results suggest the activity of POA derivatives against Sporothrix spp. may be dependent on the lipophilicity. In addition, the antifungal susceptibility of the isolates to itraconazole was performed, showing that two Sporothrix isolates from cats were itraconazole-resistant. Compounds 3 and 4 were also active against these itraconazole-resistant isolates, indicating a possible alternative route to the standard mode of action of itraconazole.

This paper to describe a case of dysontogenic urethral metaplasia in a one month old mongrel feline who also had bilateral renal dysplasia. Dysontogenic metaplasia in cats are scarce and this change may be associated with renal dysplasia and/or lower urinary tract. The animal had history of abdominal enlargement since birth and dysuria, eliminating urine only dropwise. Due to the poor prognosis we opted for euthanasia. At necropsy was observed enlarged and distended bladder, reduced kidneys and dilated and tortuous ureters. The urethra was thickened, hard to cut, and histologically, was replacing the connective tissue, cartilage and endochondral ossification areas, which features dysontogenic metaplasia. Both kidneys presented primitive appearance featuring dysplasia. Dysontogenic metaplasia in urinary tract feline with renal dysplasia, has not been described. Key words: Congenital disease. Malformation. Nephropathy. ResumoEste trabalho tem como objetivo descrever um caso de metaplasia disontogênica uretral em um felino sem raça definida de um mês de idade, que também apresentava displasia renal bilateral. Dados sobre metaplasia disontogênica em felinos são escassos e a alteração pode estar associada a displasia renal e/ ou do trato urinário inferior. O animal apresentava histórico de aumento abdominal desde o nascimento e disúria, eliminando a urina apenas por gotejamento. Devido ao prognóstico desfavorável optou-se pela eutanásia. Na necropsia observou-se bexiga aumentada e dilatada, rins diminuídos e ureteres dilatados e tortuosos. A uretra apresentava-se espessada e firme ao corte, e histologicamente, havia substituição ao tecido conjuntivo, áreas de cartilagem e zonas de ossificação endocondral, o que caracteriza metaplasia disontogênica. Ambos os rins apresentavam aspecto primitivo caracterizando a displasia renal. A metaplasia disontogênica no trato urinário de felinos com displasia renal, não tem sido descrita. Palavras-chave: Doença congênita. Malformação. Nefropatia.