Chemical and biological integration of a mouldable bioactive ceramic material capable of forming apatite in vivo in teeth

Engqvist, Håkan; Schultz-Walz, Jan Erik; Lööf, Jesper; Botton, Gianluigi A.; Mayer, D. P.; Phaneuf, Michael W.; Ahnfelt, Nils-Otto; Hermansson, Leif

doi:10.1016/j.biomaterials.2003.09.053

Cited by 110 publications

(65 citation statements)

References 12 publications

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“…Calcium aluminate-based cement (CAC) has already been studied for biomedical applications as endodontics [2][3][4][5][6] . This material presented good physical and mechanical properties 7 , biocompatibility 8,9 and acted as a chemical and mechanical barrier against bacterial microleakage 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies involving the use of CAC are based on commercial products comprising a mixture of different crystalline phases [2][3][4][5][6][7] . In vitro characterization of commercial CAC has been carried out in simulated body fluid solutions (SBF) prepared according to Kokubo's (KSBF) or Rigo's (RSBF) techniques.…”

mentioning

confidence: 99%

“…Keywords: dental cement, hydroxyapatite, simulated body fluid Al 2 O 3 -CaO route enabled the production of the target phases (CA, CA 2 , C 3 A and C 12 A 7 ) with higher purity compared to the Al 2 O 3 -CaCO 3 one in which C stands for CaO and A for Al 2 O 3 15 . Therefore, in this work in vitro characterization of calcium aluminate cement phases (CA, CA 2 , C 3 A and C 12 A 7 ) was evaluated when in contact with simulated body fluid solutions.…”

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confidence: 99%

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Characterization of Calcium Aluminate Cement Phases when in Contact with Simulated Body Fluid

et al. 2015

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Characterization of Calcium Aluminate Cement Phases when in Contact with Simulated Body Fluid

et al. 2015

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“…The continuous decrease of the micro-hardness data (Fig. 6a,b) for both investigated systems is mainly due to the process of conversion that is responsible for the highlyporous system of both synthesized materials, in addition to the poor mechanical properties of the added hydroxyapatite in CA/HA composite 30 . Investigation of density and hardness data of both indicates that the use of saliva solution as a curing medium enhances the hydration reactions of the investigated materials due to the presence of free cations and anions (Na + , K + , Ca ++ , Cl -) present in saliva solution.…”

Section: Scanning Electron Microscopymentioning

confidence: 96%

Evaluation of Calcium Aluminate/Calcium Phosphate Based Bio-Cements as Root-End Filling Material

Radwan¹,

El-Hamid²,

Abo-Almaged³

et al. 2017

Orient. J. Chem

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Nano-particles of pure single phase calcium aluminate (CA) were prepared via solid state reaction at high temperature. An ultra-pure nano-size hydroxyapatite (HA) prepared by sol-gel method was used to formulate a composite of 1:1 CA: HA. Setting times, micro-hardness, bulk density, calcium ion and phosphorus ion concentration, XRD, FTIR and scanning electron microscopy (SEM) were investigated. The results showed that the substitution of 50% by weight of pure calcium aluminate cement (CA) by nano-size hydroxyapatite (HA) has a retardation effect on setting process. The use of artificial saliva solution as hydration medium enhances the hydration process of both synthesized calcium aluminate based materials due to the formation of more hydrated compounds. Curing of calcium aluminate cement in hot and humid conditions, resulting in hardness loss and high porosity due to the conversion process, in which the compounds CAH 10 and C 2 AH 8 (hexagonal crystals) are converted into the more stable compound C 3 AH 6 (cubic crystals). The SEM studies indicated that the presence of nano-particles of hydroxyapatite in CA/ HA composite facilitated the precipitation of hydroxyapatite-like active layer, suggesting that pure CA cement has some distinctive physico-mechanical properties make it suitable for use as root end filling materials in dental applications.

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“…The in situ apatite precipitation may help to prevent the formation of secondary caries (derived from remaining voids between the filling material and the teeth) and consequently the replacement of the dental restoration. Moreover, strong bonding and apatite precipitation are parameters that make tooth restoration more similar to its original structure, which are desired features especially when comparing cements to other filling products, such as amalgam 32 . The presence of the Raman signature at 960 cm -1 corresponding to the phosphate group, attests the formation of an apatite-like layer on the compositions' surfaces after immersion in SBF or SBF/SS (Figure 7).…”

Section: Changes In the Camentioning

confidence: 99%

Improving the Radiopacity of Calcium Aluminate Cement Based Blends

et al. 2018

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The radiopacity of CAC-based compositions containing additives (ZnO, Ag and Bi 2 O 3 ) was evaluated by optical density measurements, cold crushing strength, apparent porosity, pore size distribution, in vitro apatite-formation ability (bioactivity) and cell viability. The bioactivity was assessed via pH and calcium concentration measurements in simulated body fluid (SBF) for samples previously treated or not with sodium silicate (SS) solution. The surface of the samples after treatment was analyzed by scanning electron microscopy, energy dispersive X-ray analysis and confocal Raman spectroscopy. Cell viability was evaluated by MTT and alkaline phosphatase (ALP) activity. Radiopacity results confirmed that compositions containing ZnO-Ag (25:1 wt%) and ZnO-Bi 2 O 3 (15:10 wt%) presented suitable values of radiopacity (> 3 mmAl). The identification of calcium and mainly phosphorus by EDX, highlighted the generation of an apatite-like layer on the compositions' surface after immersion in SBF or SBF/SS. CAC-blend containing 25 wt% ZnO, ZnO-Ag and ZnO-Bi 2 O 3 presented slightly lower cell viability compared to the positive control.

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Chemical and biological integration of a mouldable bioactive ceramic material capable of forming apatite in vivo in teeth

Cited by 110 publications

References 12 publications

Characterization of Calcium Aluminate Cement Phases when in Contact with Simulated Body Fluid

Characterization of Calcium Aluminate Cement Phases when in Contact with Simulated Body Fluid

Evaluation of Calcium Aluminate/Calcium Phosphate Based Bio-Cements as Root-End Filling Material

Improving the Radiopacity of Calcium Aluminate Cement Based Blends

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