Improving the Radiopacity of Calcium Aluminate Cement Based Blends

Oliveira, I. R.; Vieira, Gabriela do Vale; Santos, K.W. dos; Raniero, Leandro; Castro‐Raucci, Larissa Moreira Spinola de; Oliveira, Paulo Tambasco de; Fornari, Celso I.; Pandolfelli, V. C.

doi:10.1590/1980-5373-mr-2017-0599

Cited by 6 publications

(3 citation statements)

References 32 publications

(39 reference statements)

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“…According to the previous studies 18,25,26 the significant drop in apparent porosity observed after treatment with SBF can be explained by the presence of precipitates on the surface of the materials. Thus, the same effect should take place for the plain CH and blends with BG in the present work.…”

Section: Resultsmentioning

confidence: 84%

Calcium Aluminate Cement Blends Containing Bioactive Glass and Strontium for Biomaterial Applications

et al. 2021

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In this work blends based on calcium aluminate cement (CAC) containing bioactive glass (BG) (5, 7.5 and 10 wt%) and strontium oxide (1 wt%) were produced aiming improve their bioactivity and the capacity to stimulate the bone regeneration. In the first part, the blends containing only BG were characterized as theoretical density, microhardness, uniaxial cold crush strength after SBF and apparent porosity and pore size distribution before and after SBF treatment. In the second part, bioactivity and cell culture tests were also conducted in the blends containing BG and strontium oxide. The addition of 7.5 wt% of BG in homogeneous calcium aluminate cement (CH) improved its mechanical properties as microhardness and uniaxial cold crushing strength. The blends were more bioactive due to the presence of a highly soluble amorphous phase as confirmed by means of SEM/EDX mainly for 7.5 wt% BG without and with Sr from 1 day in SBF. FTIR analyses indicated the formation the apatite-like phase by means of increase of intensity of the PO 4 3peaks after SBF treatment. All blends allowed the development of the osteoblastic phenotype and the formation of mineralized matrix increased due to the inclusion of BG and Sr promoting the osteogenesis process.

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Section: Resultsmentioning

confidence: 84%

Calcium Aluminate Cement Blends Containing Bioactive Glass and Strontium for Biomaterial Applications

et al. 2021

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“…Besides that, other CAC-based blends, 15:10 wt% ZnO-Bi 2 O 3 , also presented apatite precipitation on its surface which filled in the pores on the solid surface. This composition showed suitable for clinical purposes in relation to radiopacity (Oliveira et al 2018). Other studies also show the biofilm formation analysis of blend of CAC with zirconia (Vasconcellos et al 2020).…”

Section: Introductionmentioning

confidence: 67%

Calcium aluminate cement-based blends for application to fill in bone defects

et al. 2020

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Introduction The need to treat bone defects is increasing dramatically as the population grows old. Calcium aluminate cement, CAC, has been applied to fill in bone defects. CAC has been used in orthopedics, as it can avoid some problems of commercial products, polymethylmethacrylate, PMMA, regarding its too low consistency and strong odor and exothermic reactions which can damage the surrounding tissue. Besides that, CAC can be molded in situ to provide intimate fitting to the defect rims. The injectability of cements is an important aspect when minimally invasive surgical techniques are used and for applications with limited accessibility and narrow cavities. Methods At present work, CAC was initially analyzed via zeta potential and viscosity when mixed with different dispersant additives. Then, CAC blends containing different materials, alumina, zirconia, zinc oxide, hydroxyapatite, tricalcium phosphate, chitosan, collagen, or zinc oxide-bismuth oxide, were evaluated regarding their injectability and by means of in vitro mineralization and ex vivo uniaxial cold crushing strength tests. The best injectability conditions, 76 wt% solids, hypodermic needle, were used for the ex vivo tests. In the latter, the compositions selected by in vitro tests were injected to repair 3-mm defects on mouse femurs cut into pieces of 10 mm, whereas collagen and PMMA were inserted with a spatula. After setting the materials for 24 h at 37°C in body fluid solution, the pieces were submitted to uniaxial cold crushing strength tests. Results The blends alumina, collagen, and chitosan resulted in greater reddish-stained areas indicating enhanced mineralized matrix formation for these groups, which also presented higher values of calcium deposits indicating a successful in vitro bonelike nodule formation. Conclusion The filling of defects with CACH and its blends increased the resistance of bones when compared to bones with the added defect, with lower effect verified in the presence of chitosan and collagen.

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“…Calcium aluminate-based cement (CAC) represents a promising alternative since it exhibits favorable physicochemical characteristics such as its thermal coefficient of and chemical composition similar to the tooth and human bone 9 – but also due to the bioactivity, i. e., its ability to form a biologically active apatite layer upon exposure to body fluids 10 – 12 . This property, also observed in calcium silicate-based cements such as mineral trioxide aggregate (MTA), involves the calcium release and the pH raise in the milieu 13 , 14 and is considered essential for the stimulating effect of these materials on cellular events that form mineralized tissues 13 .…”

Section: Introductionmentioning

confidence: 99%

Impact of calcium aluminate cement with additives on dental pulp-derived cells

et al. 2020

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Calcium aluminate cement (CAC) has been highlighted as a promising alternative for endodontic use aiming at periapical tissue repair. However, its effects on dental pulp cells have been poorly explored. Objective: This study assessed the impact of calcium chloride (CaCl2) and bismuth oxide (Bi2O3) or zinc oxide (ZnO) additives on odontoblast cell response to CAC. Methodology: MDPC-23 cells were exposed for up to 14 d: 1) CAC with 2.8% CaCl2 and 25% ZnO (CACz); 2) CAC with 2.8% CaCl2 and 25% Bi2O3 (CACb); 3) CAC with 10% CaCl2 and 25% Bi2O3 (CACb+); or 4) mineral trioxide aggregate (MTA), placed on inserts. Non-exposed cultures served as control. Cell morphology, cell viability, gene expression of alkaline phosphatase (ALP), bone sialoprotein (BSP), and dentin matrix protein 1 (DMP-1), ALP activity, and extracellular matrix mineralization were evaluated. Data were compared using ANOVA (α=5%). Results: Lower cell density was detected only for MTA and CACb+ compared with Control, with areas showing reduced cell spreading. Cell viability was similar among groups at days one and three (p>0.05). CACb+ and MTA showed the lowest cell viability values at day seven (p>0.05). CACb and CACb+ promoted higher ALP and BSP expression compared with CACz (p<0.05); despite that, all cements supported ALP activity. Matrix mineralization were enhanced in CACb+ and MTA. Conclusion: In conclusion, CAC with Bi2O3, but not with ZnO, supported the expression of odontoblastic phenotype, but only the composition with 10% CaCl2 promoted mineralized matrix formation, rendering it suitable for dentin-pulp complex repair.

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Improving the Radiopacity of Calcium Aluminate Cement Based Blends

Cited by 6 publications

References 32 publications

Calcium Aluminate Cement Blends Containing Bioactive Glass and Strontium for Biomaterial Applications

Calcium Aluminate Cement Blends Containing Bioactive Glass and Strontium for Biomaterial Applications

Calcium aluminate cement-based blends for application to fill in bone defects

Impact of calcium aluminate cement with additives on dental pulp-derived cells

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