Cheilitis granulomatosa: Report of six cases and review of the literature

Allen, Carl M.; Camisa, Charles; Hamzeh, Sahar; Stephens, Linda S.

doi:10.1016/0190-9622(90)70238-d

Cited by 87 publications

(60 citation statements)

References 20 publications

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“…Other treatment modalities which have been tried with variable success include hydroxychloroquine, antihistamines [10] and antimicrobials [11][12][13]. In this case, significant response to therapy in terms of reduction in size of the lip swelling was observed in the second week.…”

Section: Discussionmentioning

confidence: 91%

Orofacial Granulomatosis: A Clinicopathologic Correlation

Thomas

Neelakandan

Bhargava

et al. 2011

Head and Neck Pathol

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Orofacial granulomatosis is an uncommon disorder, but has been increasingly recognized in the past decade. It causes significant morbidity in the patient including oral ulcerations, enlargement of soft tissues which are often persistent and painful. This necessitates early medical intervention. We report one such case of a female patient who presented with a persistent upper lip enlargement. She had visited multiple general dental practitioners and general physicians but was undiagnosed. Ultrasonography proved an adjunctive tool in diagnosis. She was treated with a combination of topical and intra-lesional steroids. A 1-year follow-up did not show any evidence of recurrence.

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Section: Discussionmentioning

confidence: 91%

Orofacial Granulomatosis: A Clinicopathologic Correlation

Thomas

Neelakandan

Bhargava

et al. 2011

Head and Neck Pathol

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“…[4][5][6] No odontogenic infection, food hypersensitivity or genetic susceptibility was seen in our patients. Histopathologically, in some cases, oedema, perivascular mononuclear cell infiltration (as in our cases) and lymphangiectasia are seen.…”

Section: Discussionmentioning

confidence: 94%

“…[1][2][3] Cheilitis granulomatosa of Miescher (granulomatous cheilitis (GC)), is generally regarded as a monosymptomatic form of M RS. [2][3][4] The exact aetiology of MRS/GC is unknown, but various aetiopathogenetic mechanisms, including infectious agents, heredity, allergic reactions, sarcoidosis or Crohn's disease have been implicated. [4][5][6] Mycobacteria are acid-fast intracellular bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4] The exact aetiology of MRS/GC is unknown, but various aetiopathogenetic mechanisms, including infectious agents, heredity, allergic reactions, sarcoidosis or Crohn's disease have been implicated. [4][5][6] Mycobacteria are acid-fast intracellular bacteria. Protective immunity against intracellular bacteria is usually a local event resulting in granuloma formation.…”

Section: Introductionmentioning

confidence: 99%

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Possible role of Mycobacterium tuberculosis complex in Melkersson–Rosenthal syndrome demonstrated with Gen‐Probe amplified Mycobacterium tuberculosis direct test

et al. 2004

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Melkersson-Rosenthal (MRS) syndrome is characterized by a classical triad of recurrent or persistent orofacial swelling, peripheral facial nerve paralysis and lingua plicata. Granulomatous cheilitis (GC) is regarded as a monosymptomatic form of MRS. The exact aetiologies of MRS and GC are unknown. In this study we investigated the possible role of mycobacteria in these two conditions. A ribosomal RNA amplification-based Gen-Probe amplified Mycobacterium tuberculosis direct test was used to investigate the presence of M. tuberculosis complex in paraffin-embedded skin biopsy specimens from five patients with MRS and one patient with GC. Three of the six specimens were shown to be positive using this system; one of the positive specimens also showed positive Ziehl-Neelsen staining. These results suggest a possible mycobacterial aetiology for MRS and GC.

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“…Histologically, lymphedema, perivascular lymphocytic infiltration, and to a varying degree nonnecrotizing granulomas are seen. 3,4 The undefined etiology of this inflammatory disorder has led to a variety of anti-inflammatory treatment strategies. Glucocorticosteroid therapy, either systemic or intralesional, generally may reduce the macrocheilia.…”

Section: Commentmentioning

confidence: 99%