Successful Treatment of Granulomatous Cheilitis With Thalidomide

Thomas, Peter A.; Walchner, Monika; Ghoreschi, Kamran; Röcken, Martin

doi:10.1001/archderm.139.2.136

Cited by 24 publications

(15 citation statements)

References 21 publications

(16 reference statements)

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“…Corticosteroids have been used by topical, intralesional (2–3 mg of triamcinolone suspension weekly for 5–8 months), and systemic administration with variable and temporary benefit 5 . Clofazimine, hydroxychloroquine, dapsone, sulphasalazine, thalidomide, danazol and minocycline have also been employed without reproducible benefit 3,5,12,24,28 . Surgery has produced initial improvement in the appearance, but postoperative intralesional steroids are usually required and are often ineffective in preventing relapse 23 .…”

Section: Discussionmentioning

confidence: 99%

Persistent unilateral orbital and eyelid oedema as a manifestation of Melkersson–Rosenthal syndrome

Cocuroccia

Gubinelli

Annessi

et al. 2004

Acad Dermatol Venereol

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Melkersson-Rosenthal syndrome (MRS) is a complex neuromucocutaneous disorder characterized by localized orofacial oedema and cranial nerve dysfunction, frequently associated with minor signs, including furrowed tongue. Complete forms are rare whereas mono- and oligosymptomatic variants are more common. A 71-year-old man presented with a 2-year history of relapsing and progressively persistent oedema of the right eyelids and periorbital region. A fissured tongue and telangiectatic rosacea had been present since the age of 50 and 60 years, respectively. The patient was also affected by essential hypertension and diabetes mellitus. A skin biopsy showed a marked upper dermal oedema, and small epithelioid cell granulomas arranged in perivascular and perilymphatic location. Collections of small epithelioid cells were occasionally observed within lymphatic spaces. No acid-fast bacteria, fungi or foreign bodies were detected. Intralesional corticosteroids induced transient improvement, whereas minocycline, clofazimine and dapsone have been ineffective. MRS may present with unilateral eyelid and periorbital swelling. Differential diagnoses of such cases may include a variety of cutaneous, ophthalmic and systemic diseases.

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Section: Discussionmentioning

confidence: 99%

Persistent unilateral orbital and eyelid oedema as a manifestation of Melkersson–Rosenthal syndrome

Cocuroccia

Gubinelli

Annessi

et al. 2004

Acad Dermatol Venereol

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“…Similarly, in a case report by Thomas et al. , 25 thalidomide was successfully used in a patient with GC in doses of 100 mg daily which were decreased to every other day. Thalidomide also demonstrates TNF‐α inhibitory action, which may explain its effectiveness 25 .…”

Section: Other Immunomodulatorsmentioning

confidence: 93%

“…, 25 thalidomide was successfully used in a patient with GC in doses of 100 mg daily which were decreased to every other day. Thalidomide also demonstrates TNF‐α inhibitory action, which may explain its effectiveness 25 . Although these agents and the targeting of TNF‐α represent a promising avenue for future treatment, their long‐term safety and efficacy remains to be seen in addressing GC.…”

Section: Other Immunomodulatorsmentioning

confidence: 99%

A comprehensive review of current treatments for granulomatous cheilitis

Banks

Gada

2012

British Journal of Dermatology

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Granulomatous cheilitis (GC) is a poorly understood disease process belonging to the larger group of orofacial granulomatosis. The treatment of GC has proven exceedingly difficult. While various treatments have been applied to GC, there has been no uniform or predictably successful model demonstrated in the literature. Poor understanding of the aetiological mechanisms underpinning GC has significantly hampered the development of an effective approach to treatment. Those therapies that have shown promise principally consist of agents with anti-inflammatory activity such as corticosteroids and immunomodulatory medications. On a careful review of the literature, we have found no systematic review and assessment of current treatments. We seek to address this absence in the available literature by providing a consolidated overview of current treatment for GC.

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“…611 In a further case the granulomatous cheilitis was regarded as the consequence of a tuberculid. 616,621,622 Triamcinolone injections have also been used, both alone, 623,624 and combined with dapsone. 613 Occasional cases have been associated with other granulomatous skin lesions or granulomatous lymphadenopathy.…”

Section: Melkersson-rosenthal Syndromementioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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Successful Treatment of Granulomatous Cheilitis With Thalidomide

Cited by 24 publications

References 21 publications

Persistent unilateral orbital and eyelid oedema as a manifestation of Melkersson–Rosenthal syndrome

Persistent unilateral orbital and eyelid oedema as a manifestation of Melkersson–Rosenthal syndrome

A comprehensive review of current treatments for granulomatous cheilitis

The granulomatous reaction pattern

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