“…Available scientific data do not point to a single factor that can explain the development of OFG in all patients who suffer from this disease (Giovannetti et al , ). Thus, the development of OFG most likely represents the outcome of interacting factors including genetic susceptibility (Stosiek et al , ; Gibson and Wray, ), environmental factors such as the microflora (Ivanyi et al , ; Gibson et al , ; Apaydin et al , ; Savage et al , ) and host immune responses (Lim et al , ; Freysdottir et al , ; Patel et al , ; Giovannetti et al , ).…”