Charged Poly(D,L‐lactide) Nanofibers: Towards Customized Surface Properties

Abstract

Surface‐charged nanofibers were prepared by electrospinning technique (ESP). For this purpose, a copolymer bearing carboxylic acid functions was added to a poly(D,L‐lactide) solution just before ESP process. In a basic medium, negative charges were therefore revealed on fiber surface. By deposition of positively charged particles or polyelectrolytes, surface properties of the fibers could be tailor‐made for a specific application. This versatile method can, for example, be applied to the preparation of new biomedical scaffolds.

Polysaccharide‐Coated PCL Nanofibers for Wound Dressing Applications

“…As we formerly reported for polylactide (PLA), charged fibers can be obtained by electrospinning a mixture of PLA and a polyelectrolyte precursor dissolved in a common solvent. In the present work, PCL, another aliphatic polyester which degrades more slowly than PLA, was electrospun in presence of a poly(methyl methacrylate 48 ‐ b ‐methacrylic acid 25 ) diblock copolymer from an organic solvent mixture until a manipulable homogeneous fiber mat was obtained (i.e., 30 min).…”

“…It has notably proved to stimulate cell proliferation and favor histoarchitectural tissue organization . Nevertheless, the electrospinning of chitosan is challenging, notably as it requires high voltages and needs the addition of poly(ethylene oxide), as chitosan can hardly be electrospun alone . Moreover, chitosan possesses low mechanical resistance (low elongation at break), particularly in hydrated state, such as wound exudates or cell culture media, and usually requires further cross‐linking steps to keep a handable biomaterial.…”

“…To overcome these limitations, we investigate here a novel two‐step strategy for the preparation of core‐shell fibers (i) having an aliphatic polyester core to sustain mechanical stresses, (ii) exhibiting charges at the core surface to anchor a polyelectrolyte layer and (iii) possessing a polysaccharide coating to preserve the remarkable surface properties of chitosan for wound healing ( Scheme ).…”

“…This material, used as the core of the nanofibers, would thus insure the mechanical resistance required to handle the nanofibers in aqueous environments. The presence of a copolymer bearing carboxylic acid groups within the fibers would then allow exposing some charges at the nanofiber surface, as previously reported for polylactide fibers, and polyelectrolytes – such as chitosan and hyaluronic acid – could further be deposited on the fiber surface via a layer‐by‐layer process (Scheme ).…”

Chitosan-coated electrospun nanofibers with antibacterial activity

“…29 The preparation of these particles, using the co-precipitation method, is described hereafter: ferric chloride (3.2 Â 10 À2 mol) and ferrous chloride (1.6 Â 10 À2 mol) were dissolved under stirring into 25 mL of hydrochloric acid (HCl, 2 mol L À1 ), and heated at 90 1C. 29 The preparation of these particles, using the co-precipitation method, is described hereafter: ferric chloride (3.2 Â 10 À2 mol) and ferrous chloride (1.6 Â 10 À2 mol) were dissolved under stirring into 25 mL of hydrochloric acid (HCl, 2 mol L À1 ), and heated at 90 1C.…”