Charge-Transfer Complexation for Spectrophotometric Assay of Certain Imidazole Antifungal Drugs

Utility of some .PI.-Acceptors for Spectrophotometric Determination of Gatifloxacin in Pure Form and in Pharmaceutical Preparations

“…Comparison of the results obtained by the method using p-chloranil (CL) with those obtained using the same reagent in an aqueous buffer medium showed a wider range 36 Vol. 56, No.…”

“…p-Acceptors such as 7,7,8,8-tetracyanoquinodimethane (TCNQ); 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ); chloranilic acid (CLA) and p-chloranil (CL) are known to yield charge transfer complexes and radical anions with a variety of electron donors. [26][27][28][29][30][31][32][33][34][35][36] This donor-acceptor interaction has been investigated with gatifloxacin as electron donor.…”

Extractive Spectrophotometric Determination of Ketoconazole, Clotrimazole and Fluconazole by Ion-Pair Complex Formation With Bromothymol Blue and Picric Acid

“…It acts by blocking the synthesis of ergosterol, an essential component of the fungal cell membrane. Thus, due to the vital importance of determination of these drugs in pharmaceutical preparations and biological fluids, several spectroscopic [5][6][7][8][9][10][11][12]. high per-formance liquid chromatographic [13-/17] and electrochemical [18-/23] methods for assay of KC and also, various methods such as derivative spectrophotometry [24][25],colorimetry [5-6-26-27], HPLC [28-/30], electrochemistry [18] and differential scanning calorimetry (DSC) [31] have been reported for the determination of CT in the literature.…”

First-derivative ultraviolet spectrophotometric and high performance liquid chromatographic determination of ketoconazole in pharmaceutical emulsions

“…Topical ketoconazole formulations have been found to be effective in controlling seborrhoeic dermatitis without producing significant adverse reactions (Katsambas et al, 1989;Roychowdhury, Das, 1996). It is active against pityrosporum yeasts both "in vitro" and "in vivo" (El-Shabouri et al, 1998).…”

“…Ketoconazole is an imidazole derivative with a wide antifungal spectrum and possesses some antibacterial activity (El-Shabouri et al, 1998;Hardman, Limbird, Gilman, 2001;Korolkovas, 1988). administration (Abounassif, El-Shazly, 1989;Hardman, Limbird, Gilman, 2001;Korolkovas, 1988).…”