Charge Separating Microfiltration Membrane with pH-Dependent Selectivity

Breite, Daniel; Went, Marco; Prager, Andrea; Kuehnert, Mathias; Schulze, Agnes

doi:10.3390/polym11010003

Cited by 22 publications

(15 citation statements)

References 53 publications

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“…In these processes, the success of the separation (specifically purity and yield) is given by the selectivity and permeability of the membrane, characteristics of the compounds (e.g., molecular mass, dimensions, and polarity), and operating parameters (e.g., pressure, flux, and temperature) . Importantly, the type of membrane material also plays an important role on the separation of solutes.…”

Section: Membrane Technology: Pressure‐driven Membrane Processesmentioning

confidence: 99%

“…Moreover, the performance of the membranes is gradually affected by the fouling phenomenon that is generated during the separation; such phenomenon can be controlled by decreasing membrane–compound interaction …”

Section: Membrane Technology: Pressure‐driven Membrane Processesmentioning

confidence: 99%

“…Complete blockage occurs when molecules with a greater MWCO than the membrane physically obstruct the pore. Blocking by polarization is the accumulation of solute molecules on the surface of the membrane; partial blockage of the pores is due to the internal deposition of the matter, and at this point, the morphology and orientation of the molecules may cause their entrapment; and finally, the blocking by adsorption is taking place on the pores surface or internally by the effect of physicochemical interactions (e.g., hydrophobic, polar, or charge transfer) …”

Section: Membrane Technology: Pressure‐driven Membrane Processesmentioning

confidence: 99%

“…Other studies propose the use of zwitterionic membranes for the separation of mixtures with double charge compounds (e.g., proteins) and the modification of the surface of the membrane to improve filtration …”

Section: Membrane Technology: Pressure‐driven Membrane Processesmentioning

confidence: 99%

See 3 more Smart Citations

Metabolites recovery from fermentation broths via pressure‐driven membrane processes

Díaz‐Montes

Castro‐Muñoz

2019

Asia-Pacific J Chem Eng

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The production of specific metabolites using microorganism has been promoted and enhanced by two different approaches, such as modification of the metabolic pathways of microorganism and optimization of culture medium conditions to synthesize specific compounds. However, research community is today focused on the development of processes and techniques for a suitable recovery of metabolites from different stages of fermentation. For this purpose, the use of organic solvents has been the most common approach for the recovery of specific target compounds according to the solvent affinity. Additionally, these techniques also require the implementation of unit processes to obtain better recovery rates; it means that solvent extraction methods need the implementation of additional steps to recover the solvents used, which may involve the increase of final costs in the production process. For this reason, researchers have started to consider membrane-based technologies (e.g. microfiltration [MF], ultrafiltration [UF], and nanofiltration [NF]), as an alternative for the recovery of metabolites from fermentation broths. Therefore, the objective of this paper is to provide an overview of the current findings of the recovery of metabolites from fermentation broths by means of pressuredriven membrane processes. Particular attention will be paid to relevant data, analyzing and discussing according to the membrane features, metabolite properties, and some other phenomena that influence in the separation.Moreover, a framework of the application of the MF, UF, and NF processes in solutes recovery is addressed. Finally, some fundamentals of these processes are also given.

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Section: Membrane Technology: Pressure‐driven Membrane Processesmentioning

confidence: 99%

Section: Membrane Technology: Pressure‐driven Membrane Processesmentioning

confidence: 99%

Section: Membrane Technology: Pressure‐driven Membrane Processesmentioning

confidence: 99%

Section: Membrane Technology: Pressure‐driven Membrane Processesmentioning

confidence: 99%

See 2 more Smart Citations

Metabolites recovery from fermentation broths via pressure‐driven membrane processes

Díaz‐Montes

Castro‐Muñoz

2019

Asia-Pacific J Chem Eng

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“…The interactions between membranes and foulants are mainly based on hydrophobic and electrostatic interactions. The reduction of these interactions can be realized by modifying the membrane surface via changes in e.g., the surface charge, morphology, or surface hydrophilicity [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Reduction of Biofouling of a Microfiltration Membrane Using Amide Functionalities—Hydrophilization without Changes in Morphology

et al. 2020

Self Cite

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A major goal of membrane science is the improvement of the membrane performance and the reduction of fouling effects, which occur during most aqueous filtration applications. Increasing the surface hydrophilicity can improve the membrane performance (in case of aqueous media) and decelerates membrane fouling. In this study, a PES microfiltration membrane (14,600 L m−2 h−1 bar−1) was hydrophilized using a hydrophilic surface coating based on amide functionalities, converting the hydrophobic membrane surface (water contact angle, WCA: ~90°) into an extremely hydrophilic one (WCA: ~30°). The amide layer was created by first immobilizing piperazine to the membrane surface via electron beam irradiation. Subsequently, a reaction with 1,3,5-benzenetricarbonyl trichloride (TMC) was applied to generate an amide structure. The presented approach resulted in a hydrophilic membrane surface, while maintaining permeance of the membrane without pore blocking. All membranes were investigated regarding their permeance, porosity, average pore size, morphology (SEM), chemical composition (XPS), and wettability. Soxhlet extraction was carried out to demonstrate the stability of the applied coating. The improvement of the modified membranes was demonstrated using dead-end filtration of algae solutions. After three fouling cycles, about 60% of the initial permeance remain for the modified membranes, while only ~25% remain for the reference.

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Prediction models for the flux decay profile and initial flux of microfiltration for therapeutic proteins

Inoue,

Masuda,

Torisu

et al. 2024

Biotech & Bioengineering

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Microfiltration (MF) is an essential step during biopharmaceutical manufacturing. However, unexpected flux decay can occur. Although the flux decay profile and initial flux are important factors determining MF filterability, predicting them accurately is challenging, as the root cause of unexpected flux decay remains elusive. In this study, the methodology for developing a prediction model of flux decay profiles was established. First, the filtration profiles of different monodisperse polystyrene latex and silica beads of various sizes were evaluated. These results revealed that the size and surface electrostatic properties of the beads affect the flux decay profile. Taking the size and surface electrostatic properties of protein aggregates into account, we constructed a predictive model using model bead filtration profiles. We showed that this methodology was applicable to two different MF filters to predict the flux decay profile of therapeutic proteins. Because our proposed prediction model is based on normalized flux, the initial flux is required to predict the overall filtration profile. Then, we applied the Hagen–Poiseuille equation using sample viscosity values to estimate the initial flux. The developed prediction models can be used for effective MF scale‐up assessment during the early stages of process development.

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Charge Separating Microfiltration Membrane with pH-Dependent Selectivity

Cited by 22 publications

References 53 publications

Metabolites recovery from fermentation broths via pressure‐driven membrane processes

Metabolites recovery from fermentation broths via pressure‐driven membrane processes

Reduction of Biofouling of a Microfiltration Membrane Using Amide Functionalities—Hydrophilization without Changes in Morphology

Prediction models for the flux decay profile and initial flux of microfiltration for therapeutic proteins

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