Prediction models for the flux decay profile and initial flux of microfiltration for therapeutic proteins
Kota Inoue,
Yumiko Masuda,
Tetsuo Torisu
et al.
Abstract:Microfiltration (MF) is an essential step during biopharmaceutical manufacturing. However, unexpected flux decay can occur. Although the flux decay profile and initial flux are important factors determining MF filterability, predicting them accurately is challenging, as the root cause of unexpected flux decay remains elusive. In this study, the methodology for developing a prediction model of flux decay profiles was established. First, the filtration profiles of different monodisperse polystyrene latex and sil… Show more
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