Characterizing the Wave Aberration in Eyes with Keratoconus or Penetrating Keratoplasty Using a High–Dynamic Range Wavefront Sensor

Pantanelli, Seth; MacRae, Scott; Jeong, Tae Moon; Yoon, Geunyoung

doi:10.1016/j.ophtha.2007.01.008

Cited by 126 publications

(104 citation statements)

References 32 publications

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“…For astigmatism, the ranges given here are equivalent to ∼30 D for the improved algorithms (the conversion factor between Zernike coefficient and ophthalmic prescription is ∼0.77 for defocus and ∼1.09 for astigmatism at a pupil size of 6.0 mm). This is far in excess of any case of astigmatism ever reported to our knowledge, even in eyes with severe corneal distortion 17 or far away from the optical axis. 18 The defocus results for the improved algorithms correspond to ∼13.3 to 16.6 D of refractive error.…”

Section: Resultsmentioning

confidence: 55%

Comparison of sorting algorithms to increase the range of Hartmann-Shack aberrometry

Bedggood

Metha

2010

J. Biomed. Opt.

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Abstract. Recently many software-based approaches have been suggested for improving the range and accuracy of Hartmann-Shack aberrometry. We compare the performance of four representative algorithms, with a focus on aberrometry for the human eye. Algorithms vary in complexity from the simplistic traditional approach to iterative spline extrapolation based on prior spot measurements. Range is assessed for a variety of aberration types in isolation using computer modeling, and also for complex wavefront shapes using a real adaptive optics system. The effects of common sources of error for ocular wavefront sensing are explored. The results show that the simplest possible iterative algorithm produces comparable range and robustness compared to the more complicated algorithms, while keeping processing time minimal to afford real-time analysis. C 2010 Society of Photo-Optical Instrumentation Engineers.

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Section: Resultsmentioning

confidence: 55%

Comparison of sorting algorithms to increase the range of Hartmann-Shack aberrometry

Bedggood

Metha

2010

J. Biomed. Opt.

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“…Large pupil allowed more scattered light to be detected, and the effect of higherorder aberrations on OSI increased with pupil sizes. In addition, previous studies [11,12] showed that there were larger amounts of higher-order aberrations in the diseased eyes than in the healthy eyes. Presumably, the effect of higher-order aberrations on the OSI value should be larger in diseased eyes.…”

Section: Discussionmentioning

confidence: 86%

“…Meanwhile, compared with the values calculated from the measured aberration data in the same eye, they selected the peripheral zone where the effect of scatter was significant and the effect of aberrations was small. However, the effect of aberrations on the peripheral zone of PSF would lead to a misleading estimate of intraocular scatter in situations where a significant amount of higher-order aberrations is presented [1], such as in diseased eyes which have larger higher-order aberrations than healthy eyes [11,12]. On the other hand, to obtain complete optical transfer function of the eye, most DP systems were based on an unequal pupil configuration with a 1.5-mm or 2-mm diameter in the entrance pupil and a 4-mm diameter in the exit pupil [9,13].…”

Section: Introductionmentioning

confidence: 99%

Quantifying intraocular scatter with near diffraction-limited double-pass point spread function

Zhao

Xiao

Kang

et al. 2016

Biomed. Opt. Express

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Measurement of the double-pass (DP) point-spread function (PSF) can provide an objective and non-invasive method for estimating intraocular scatter in the human eye. The objective scatter index (OSI), which is calculated from the DP PSF images, is commonly used to quantify intraocular scatter. In this article, we simulated the effect of higher-order ocular aberrations on OSI, and the results showed that higher-order ocular aberrations had a significant influence on OSI. Then we developed an adaptive optics DP PSF measurement system (AO-DPPMS) which was capable of correcting ocular aberrations up to eighth-order radial Zernike modes over a 6.0-mm pupil. Employing this system, we obtained DP PSF images of four subjects at the fovea. OSI values with aberrations corrected up to 2nd, 5th and 8th Zernike order were calculated respectively, from the DP PSF images of the four subjects. The experimental results were consistent with the simulation, suggesting that it is necessary to compensate for the higher-order ocular aberrations for accurate intraocular scatter estimation.

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“…Pantanelli et al, 9 averaging across 33 keratoconic eyes, obtained a higher-order-aberration RMS of around 2.24 μm for a 6 mm pupil diameter, which is around 5 times more than in "normal" eyes. In these eyes, the neural compensation of the visual system should be larger than in "normal" eyes.…”

Section: Introductionmentioning

confidence: 96%

Visual Tasks Dependence of the Neural Compensation for the Keratoconic Eye's Optical Aberrations

Rouger

Bénard

Gatinel

et al. 2010

Journal of Optometry

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PURPOSE: To investigate whether "normal" eyes viewing through keratoconic (KC) eye aberrations can achieve a similar visual performance (VP) to that of KC eyes. METHOD: We measured the high-contrast visual acuity (VA) and the 10, 15 and 20 c/deg contrast sensitivity (CS) of 6 KC eyes and 6 "normal" eyes while dynamically correcting their monochromatic aberrations. The VP of both populations was also measured when viewing through the usual sphero-cylindrical correction (i.e. spectacle correction) of each KC eye. In both cases, the desired wavefront was simulated thanks to a deformable mirror. RESULTS: During dynamic correction, both KC and "normal" eyes showed similar (P>0.10) amounts of higher-order aberrations (in average, 0.10 μm of RMS for a 5.5 mm pupil). The difference between KC and "normal" eyes' VP was 0.24 log units and 0.12 log-MAR in terms of CS and VA, respectively. When viewing through KC eye aberrations, "normal" eyes showed comparable or slightly better CS (difference of 0.05 log units) but lower VA (difference of 0.13 logMAR) than KC eyes. CONCLUSIONS: KC subjects are adapted to their poor retinal image quality. However, this neural adaptation might only occur for usual "real life" visual tasks (i.e., VA-related tasks). (J Optom 2010;3:60-65 ©2010 Spanish Council of Optometry) KEY WORDS: blur adaptation; aberrations; keratoconus; contrast sensitivity; visual acuity; adaptive optics. RESUMEN OBJETIVO:Investigar si un ojo "normal" que ve a través del patrón de aberraciones de un ojo con queratocono (QC) puede lograr una calidad visual (CV) similar a la que tiene un ojo con QC. MÉTODOS: Hemos medido la agudeza visual (AV) de alto contraste y la sensibilidad al contraste (SC) a 10, 15 y 20 ciclos/grado en 6 ojos con QC y en 6 ojos "normales", a la vez que corregíamos de manera dinámica sus aberraciones monocromáticas. También se midió la CV de ambos grupos, pero esta vez anteponiendo la corrección esferocilíndrica habitual (es decir, la corrección de sus gafas) de cada uno de los ojos con QC participantes en el estudio. En ambos casos, el frente de onda deseado se generó por medio de un espejo deformable. RESULTADOS: Durante la corrección dinámica, tanto los ojos con QC como los "normales" presentaron una cantidad similar (P>0,10) de aberraciones de alto orden (RMS promedio: 0,10 μm para un diámetro de pupila de 5,5 mm). La diferencia de CV entre ojos con QC y ojos "normales" resultó ser igual a 0,24 unidades log. (SC) y a 0,12 logMAR (AV). Cuando se hizo ver a ojos "normales" a través del patrón de aberraciones de ojos con QC, se observó que los ojos "normales" tienen una SC comparable o ligeramente mejor que los ojos con QC (diferencia de 0,05 unidades log.) pero una AV más baja (diferencia de 0,13 logMAR). CONCLUSIONES: Los sujetos con QC están adaptados a la mala calidad de su imagen retiniana. Sin embargo, esta adaptación neuronal podría producirse únicamente en el contexto de tareas visuales habituales de la "vida diaria" (es decir, aquellas presentes en un test de AV). (J Optom 2010;3...

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Characterizing the Wave Aberration in Eyes with Keratoconus or Penetrating Keratoplasty Using a High–Dynamic Range Wavefront Sensor

Cited by 126 publications

References 32 publications

Comparison of sorting algorithms to increase the range of Hartmann-Shack aberrometry

Comparison of sorting algorithms to increase the range of Hartmann-Shack aberrometry

Quantifying intraocular scatter with near diffraction-limited double-pass point spread function

Visual Tasks Dependence of the Neural Compensation for the Keratoconic Eye's Optical Aberrations

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