Characterization of vesicles prepared with various non-ionic surfactants mixed with cholesterol

Manosroi, Aranya; Wongtrakul, Paveena; Manosroi, Jiradej; Sakai, Hideki; Sugawara, Fumio; Yuasa, Makoto; Abe, Masahiko

doi:10.1016/s0927-7765(03)00080-8

Cited by 326 publications

(242 citation statements)

References 28 publications

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“…For this reason, in this study, we investigated the different classes of non-ionic surfactants meanwhile keeping the other factors invariable and the corresponding order follows the order Span604Span404Span20 (Table 2). According to the results, it might be concluded that the longer alkyl chain length of non-ionic surfactants leads to the expansion of the bilayer thereby being easy to maintain waterinsoluble drug in the structure, which is consistent with the other previous report (Manosroi et al, 2003). In fact, the encapsulation efficiency of P-GNA-NISVs was about 68.20% in a molar ratio of 4:3 between Span 60 and cholesterol, which is not very promising.…”

Section: Encapsulation Efficiency Of the P-gna-nisvssupporting

confidence: 77%

PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid

et al. 2013

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Gambogenic acid (GNA), a popular Chinese traditional medicine, has its limitations of coming into use due to its low aqueous solubility and poor bioavailability. In this study, therefore, the PEGylated non-ionic surfactant vesicles drug delivery systems were prepared from biocompatible non-ionic surfactant of Span60, cholesterol and dicetyl phosphate (DCP) by the improved ethanol injection method, and were modified with a polyethylene glycol monostearate15 (PEG15-SA). PEG15-SA, as a biocompatible, non-toxic and non-immunogenic hydrophilic segment, was grafted onto the surface of colloidal niosomes carries to reduce the uptake by the reticuloendothelial system (RES), prolonging the circulation time and attaining higher entrapment efficiency. To our knowledge, this work is the first to report that PEG15-SA was applied to coating of niosomes for encapsulation of GNA. The optimized PEG-GNA-NISVs (P-GNA-NISVs) were characterized in terms of mean vesicles size, polydispersity index (PDI), Zeta potential and entrapment efficiency of the P-GNA-NISVs. The results showed that the mean diameter, PDI, Zeta potential, and the entrapment efficiency of the P-GNA-NISVs were 70.1 nm, 0.166, À44.3 mV and 87.74%, respectively. Furthermore, the release studies of GNA from PEGylated niosomes in vitro and the pharmacokinetics in vivo exhibited a prolonged release profile as studied over 24 h. In conclusion, the result suggests that P-GNA-NISVs prepared in this way not only have higher encapsulation capacity, more colloidal stability but also offer an approach that the PEGylated niosomes is a promising carrier for anticancer GNA.

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Section: Encapsulation Efficiency Of the P-gna-nisvssupporting

confidence: 77%

PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid

et al. 2013

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“…The PEO-PPO-PEO block copolymer vesicles with high stability should provide various opportunities for material, biological and medical applications such as drug delivery system [25]. Thus, several approaches have been attempted to improve the stability of PEO-PPO-PEO block copolymer vesicles, polymer vesicles (polymersomes) and nonionic surfactant vesicles (noisomes): utilization of hydrophobic block copolymers such as poly(ethylene oxide)-poly(ethyl ethylene) [26], poly(ethylene oxide)-cholesterol [27], poly(ethylene oxide)-poly(propylene oxide)-poly(lactic acid) [28] or mixing of polymers, surfactants and hydrophobic components, for example, Pluronic P123/sodium dodcyl sulfate/NaF mixture [29], Pluronic L121/Pluronic P85/pentaerythritol tetraacrylate mixture [30], a poly(ethylene glycol)/Tween 80/Span 80 mixture [31][32][33][34][35], nonionic surfactant/cholesterol mixture [36,37], poly(ethylene glycol)-b-poly(sodium methacrylate)/cationic surfactant mixture [38], poly(ethylene glycol)-b-poly(acrylic acid)/azobenzene-containing surfactant mixture [39] and poly(ethylene oxide)-b-poly(1,2-butylene oxide)/ionic surfactant mixture [40].…”

Section: Introductionmentioning

confidence: 99%

Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water

Sakai

Kurosawa

Okada

et al. 2011

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Fabrication of vesicles with the diameter of 4-30 m was achieved by mixing of a hydrophobic nonionic surfactant (Span 65) with a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer (Pluronic P123) in aqueous solutions at room temperature. Ring-shaped structure of the Pluronic P123/Span 65 mixture assemblies was confirmed by fluorescence microscopy. The presence of internal aqueous phase in the Pluronic P123/Span 65 mixture assemblies was determined by measuring the entrapment efficiency of calcein using fluorescence spectroscopy. On the other hand, Pluronic P123/Span 60 mixture system formed wire-like assemblies but not vesicles.

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“…This was poured into the thin film and vortexed continuously for a period of 30 min at room temperature. [4,6] …”

Section: Preparation Of Niosomesmentioning

confidence: 99%

“…Topical applicability of niosomes was further enhanced by developing niosomal gel formulation using carbopals. [5,6] The release from the niosomal gel of other ingredients that act as skin permeation co-enhancers. [7,8] Chemically Tetracycline is (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (Fig No.1 ) inhibits protein synthesis by binding to 30S ribosomes the attachment of aminoacyl-t-RNA to the acceptor A site of mRNA ribosome.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Tetracycline Niosomal Topical Gel Drug Delivery System

Joice¹

2017

WJPPS

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The core objective of the present study is to formulate Tetracycline niosomes for topical delivery system by hand shaking method. The prepared niosomes are to be characterized for their size, shape, stability, entrapment efficiency, invitro drug release and retention study. The formulation 1(F1) was more stable when compared to other formulations with smaller size vesicles and showed higher entrapment efficiency. The best formulation was prepared as gel with suitable gel base. The Tetracycline Niosomal gel delivery may reduce the frequency of dosing intervals and improve patient compliance.

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Characterization of vesicles prepared with various non-ionic surfactants mixed with cholesterol

Cited by 326 publications

References 28 publications

PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid

PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid

Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water

Formulation and Evaluation of Tetracycline Niosomal Topical Gel Drug Delivery System

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