“…[1][2][3][4][5] For negligible anisotropy in the medium, the index of refraction, n, characterizing the optical properties of a tissue, can be expressed in its complex form: n ϭ 1 Ϫ ␦ ϩ i, where ␦ is the decrement of the real part of the refractive index responsible for the phase shift, whereas the imaginary part, , describes the attenuation properties of the material. So far, in clinical applications like radiography, mammography, or computed tomography, only x-ray attenuation-described by -is used for image generation.…”