Characterization of the novel HLA‐C*07:639 allele by sequencing‐based typing

Abstract

HLA‐C*07:639 differs from HLA‐C*07:19 by one nucleotide substitution at codon 324 in exon 6.

Evaluation of the AllType kit for HLA typing using the Ion Torrent S5 XL platform

“…The "Mismatch in exon" warning was observed for 43 (0.7%) alleles, representing 1.9% of all warnings (43/2324). Following sequence review, 11 of these were considered probably new, of which nine were confirmed by re-typing and were referenced, [37][38][39][40][41][42][43][44][45] and two had already been described in the IPD-IMGT/HLA database. The other 32 exon mismatches were not considered new alleles because of homopolymers (15/43), high background (1/43), low read depth (9/43), or phasing anomalies (7/43) ( Table 1).…”

Characterization of the novel HLA‐C*07:639 allele by sequencing‐based typing

“…The name C*07:639 has been officially assigned by the World Health Organization (WHO) Nomenclature Committee in July 2018. This follows the agreed policy that subject to the conditions stated in the most recent Nomenclature Report, 3 names will be assigned to new sequences as they are identified. Lists of such new names will be published in the following WHO Nomenclature Report.…”