Characterization of the interaction between carbon black and three important antioxidant proteins using multi spectroscopy and modeling simulations

Hematological effects of ultrafine carbon black on red blood cells and hemoglobin

“…As shown in Figure A, when the concentration of UFCB is 20 mg/L, the activity of SOD is decreased by 26.43% compared with the control group, indicating that the UFCB inhibited the activity of SOD, which weakened the body's ability to scavenge oxygen free radicals and led to oxidative stress. The binding site of UFCB to SOD is in a hydrophobic cavity and close to the active center of SOD . UFCB changed the enzyme activity of SOD in hRBCs.…”

“…The binding site of UFCB to SOD is in a hydrophobic cavity and close to the active center of SOD. [38] UFCB changed the enzyme activity of SOD in hRBCs.…”

NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption

“…silicon nanoparticles, carbon nanotubes) also decrease antioxidant enzyme activity in other types of endothelial cells, such as in human umbilical vein endothelial cells (HUVECs) (Cao et al 2017). These enzymes undergo functional changes by direct interactions with NPs (Zhang et al 2019). A decrease in the antioxidant activity might explain the NiONPs-induced oxidative stress in HPAEC.…”

Cellular and molecular mechanisms of NiONPs toxicity on eel hepatocytes HEPA-E1: An illustration of the impact of Ni release from mining activity in New Caledonia

“…As regards as the antioxidant enzymes after ROS overproduction, the antioxidant system induced the production of antioxidant enzymes to maintain the redox balance (Sies et al, 2017). However, some authors have shown a decrease in antioxidant enzyme activity, like sod and cat, in liver tissue of juvenile carp (Cyprinus carpio) after TiO 2 NPs exposure (Hao et al, 2009), that could be explained by a direct interaction between NPs and antioxidant enzymes, which undergoes a functional change (Zhang et al, 2019). In our study, similar results were observed with an increase in sod cu/zn and cat transcriptions and a decrease in SOD activity.…”