Cellular and molecular mechanisms of NiONPs toxicity on eel hepatocytes HEPA-E1: An illustration of the impact of Ni release from mining activity in New Caledonia

Wastewater treatment plants (WWTPs) continuously release a complex mixture of municipal, hospital, industrial, and runoff chemicals into the aquatic environment. These contaminants are both legacy contaminants and emerging-concern contaminants, affecting all tissues in a fish body, particularly the liver. The fish liver is the principal detoxifying organ and effects of consistent pollutant exposure can be evident on its cellular and tissue level. The objective of this paper is thus to provide an in-depth analysis of the WWTP contaminants’ impact on the fish liver structure, physiology, and metabolism. The paper also gives an overview of the fish liver biotransformation enzymes, antioxidant enzymes, and non-enzymatic antioxidants, their role in metabolizing xenobiotic compounds and coping with oxidative damage. Emphasis has been placed on highlighting the vulnerability of fish to xenobiotic compounds, and on biomonitoring of exposed fish, generally involving observation of biomarkers in caged or native fish. Furthermore, the paper systematically assesses the most common contaminants with the potential to affect fish liver tissue. Graphical Abstract

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Fish liver damage related to the wastewater treatment plant effluents

Popović

Čižmek

Babić

et al. 2023

Environ Sci Pollut Res

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Toxicity Research Progress of Nickel Oxide Nanoparticles Exposure in the Environment

Bai,

Zhang,

Guo

et al. 2024

Curr Pollution Rep

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Whole-transcriptome sequencing revealed differentially expressed mRNAs and non-coding RNAs played crucial roles in NiONPs-induced liver fibrosis

Zheng

Liu

et al. 2022

Ecotoxicology and Environmental Safety

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Cellular and molecular mechanisms of NiONPs toxicity on eel hepatocytes HEPA-E1: An illustration of the impact of Ni release from mining activity in New Caledonia

Cited by 4 publications

References 63 publications

Fish liver damage related to the wastewater treatment plant effluents

Fish liver damage related to the wastewater treatment plant effluents

Toxicity Research Progress of Nickel Oxide Nanoparticles Exposure in the Environment

Whole-transcriptome sequencing revealed differentially expressed mRNAs and non-coding RNAs played crucial roles in NiONPs-induced liver fibrosis

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