Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life

Ricciardolo, Fabio Luigi Massimo; Sprio, Andrea Elio; Baroso, Andrea; Gallo, Fabio; Riccardi, Elisa; Bertolini, Francesca; Carriero, Vitina; Arrigo, Elisa; Ciprandi, Giorgio

doi:10.3390/biomedicines9111684

Cited by 51 publications

(43 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the negative association of HP generation with blood eosinophilia in a multiple regression model suggests that oxidative stress in asthma is not related to the T2 response [ 1 , 12 ]. Thus, our report is consistent with several epidemiological studies that indicate that an increased risk of cardiovascular diseases in asthma occurs primarily in the late-onset asthma phenotype [ 34 , 35 ] or even in women with adult asthma [ 17 ], more frequently representing the non-T2 phenotype [ 36 , 37 ].…”

Section: Discussionsupporting

confidence: 92%

Increased Oxidative Stress in Asthma—Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices

et al. 2022

View full text Add to dashboard Cite

Airway inflammation in asthma is related to increased reactive oxygen species generation, potentially leading to tissue injury and subsequent airway remodeling. We evaluated oxidative stress in peripheral blood from asthmatic subjects (n = 74) and matched controls (n = 65), using recently developed real-time monitoring of the protein hydroperoxide (HP) formation by the coumarin boronic acid (CBA) assay. We also investigated the relation of the systemic oxidative stress response in asthma to disease severity, lung function, airway remodeling indices (lung computed tomography and histology), and blood and bronchoalveolar lavage fluid (BAL) inflammatory biomarkers. We documented enhanced systemic oxidative stress in asthma, reflected by 35% faster and 58% higher cumulative fluorescent product generation in the CBA assay (p < 0.001 for both). The dynamics of HP generation correlated inversely with lung function but not with asthma severity or histological measures of airway remodeling. HP generation was associated positively with inflammatory indices in the blood (e.g., C-reactive protein) and BAL (e.g., interleukin [IL]-6, IL-12p70, and neutrophil count). Bronchial obstruction, thicker airway walls, increased BAL IL-6, and citrullinated histone 3 in systemic circulation independently determined increased HP formation. In conclusion, a real-time CBA assay showed increased systemic HP generation in asthma. In addition, it was associated with inflammatory biomarkers, suggesting that proper disease control can also lead to a decrease in oxidative stress.

show abstract

Section: Discussionsupporting

confidence: 92%

Increased Oxidative Stress in Asthma—Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices

et al. 2022

View full text Add to dashboard Cite

show abstract

“…T2 low inflammation is associated with a high cumulative exposure to tobacco smoke. 52,156 Specific drug therapies are not currently available to target T2 low inflammation.…”

Section: T2 Low Neutrophilic And/or Paucigranulocytic Inflammationmentioning

confidence: 99%

Cigarette Smoking and Asthma

Thomson¹,

Polosa²,

Sin³

2022

The Journal of Allergy and Clinical Immunology: In Practice

View full text Add to dashboard Cite

“…T2-low inflammation is associated with a high cumulative exposure to tobacco smoke. 52,157 Specific drug therapies are not currently available to target T2-low inflammation.…”

Section: T2 Eosinophilic Inflammation Statusmentioning

confidence: 99%