Increased Oxidative Stress in Asthma—Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices

Bazan-Socha, Stanisława; Wójcik, Krzysztof; Olchawa, Magdalena; Sarna, Tadeusz; Pięta, Jakub; Jakieła, Bogdan; Soja, Jerzy; Okoń, Krzysztof; Zarychta, Jacek; Zaręba, Lech; Stojak, Michał; Potaczek, Daniel P.; Bazan, Jan G.; Celińska-Löwenhoff, Magdalena

doi:10.3390/biomedicines10071499

Cited by 10 publications

(4 citation statements)

References 41 publications

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“…Studies on ex vivo models of obstructive airway disease have identified that oxidative stress, through its impact on mitochondrial function, drives airway inflammation and remodeling [ 76 , 77 , 78 ]. More specifically, in response to ozone stimulation, mitochondrial dysfunction triggers the development of airway inflammation and hyperresponsiveness [ 79 ].…”

Section: Relevant Sectionsmentioning

confidence: 99%

Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review

et al. 2023

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Obesity-related asthma is a heterogeneous childhood asthma phenotype with rising prevalence. Observational studies identify early-life obesity or weight gain as risk factors for childhood asthma development. The reverse association is also described, children with asthma have a higher risk of being obese. Obese children with asthma have poor symptom control and an increased number of asthma attacks compared to non-obese children with asthma. Clinical trials have also identified that a proportion of obese children with asthma do not respond as well to usual treatment (e.g., inhaled corticosteroids). The heterogeneity of obesity-related asthma phenotypes may be attributable to different underlying pathogenetic mechanisms. Although few childhood obesity-related asthma endotypes have been described, our knowledge in this field is incomplete. An evolving analytical profiling technique, metabolomics, has the potential to link individuals’ genetic backgrounds and environmental exposures (e.g., diet) to disease endotypes. This will ultimately help define clinically relevant obesity-related childhood asthma subtypes that respond better to targeted treatment. However, there are challenges related to this approach. The current narrative scoping review summarizes the evidence for metabolomics contributing to asthma subtyping in obese children, highlights the challenges associated with the implementation of this approach, and identifies gaps in research.

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Section: Relevant Sectionsmentioning

confidence: 99%

Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review

et al. 2023

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“…Damage to proteins, lipids and nucleic acid as a result of oxidative stress leads to pathological changes in airway epithelial cells, resulting in increased airway permeabili ty and hyperresponsiveness, as well as mucus production [25] (Figure 3).…”

Section: Ros In the Pathogenesis Of Asthmamentioning

confidence: 99%

Participation of reactive oxygen species in the pathogenesis of atopic dermatitis, allergic rhinitis and asthma

Skalska¹,

Kleniewska²,

Pawliczak³

2023

pja

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Reactive oxygen species (ROS) are any usually highly reactive chemical compounds that contain an oxygen atom with an unpaired electron in their structure. In physiological conditions, they are involved in many metabolic reactions in the body, while they are also involved in the pathogenesis of diseases such as atopic dermatitis, allergic rhinitis and asthma. Excessive ROS and antioxidant barrier dysfunction cause oxidative stress, resulting in increased oxidative damage in cells, disruption of their proper functioning and induction of a chronic inflammatory process. Key woRdsatopic dermatitis, allergic rhinitis, asthma, reactive oxygen species.stReszczenie Reaktywne formy tlenu (RFT) to zwykle wysoce reaktywne związki chemiczne, które zawierają w swojej struk turze atom tlenu z niesparowanym elektronem. W warunkach fizjologicznych biorą udział w wielu reakcjach metabolicznych zachodzących w organizmie, ale uczestniczą także w patogenezie chorób, takich jak atopowe zapalenie skóry, alergiczny nieżyt nosa lub astma. Nadmierne wytwarzanie RFT i dysfunkcja bariery anty oksydacyjnej prowadzą do rozwoju stresu oksydacyjnego, co skutkuje zwiększeniem uszkodzeń oksydacyjnych w komórkach, zaburzeniem ich prawidłowego funkcjonowania oraz indukcją przewlekłego procesu zapalnego.słowa Kluczowe atopowe zapalenie skóry, alergiczny nieżyt nosa, astma, reaktywne formy tlenu.

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“…Oxidative stress is caused by oxidative reactions that affect cells containing high levels of ROS ( 9 ). Since oxidative stress contributes to asthma severity ( 10 ), factors that reduce its severity should help prevent asthma. ROS are typically detoxified by antioxidant mechanisms such as those involving the enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx).…”

Section: Introductionmentioning

confidence: 99%

GliSODin® prevents airway inflammation by inhibiting T-cell differentiation and activation in a mouse model of asthma

et al. 2023

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BackgroundAsthma is a chronic inflammatory airway disease characterized by a prevailing type 2 inflammation, airway hyperresponsiveness, and mucus hypersecretion and is driven by various factors among which oxidative molecules, called reactive oxygen species (ROS), play a major role. Superoxide dismutases (SODs) are enzymes that constitute the first line of defense against ROS. Melon SOD-gliadin, which is known as GliSODin®, is commonly used as a nutritional supplement that has proven antioxidant properties.ObjectivesIn this study, we evaluated the efficacy and mechanism of action GliSODin® in the treatment of allergic asthma.MethodsHouse dust mite (HDM)-induced asthmatic mice were orally exposed to GliSODin®, and airway hyperresponsiveness, lung inflammation, in vitro T-cell polarization, in vivo T-cell reactivation, and blood immunoglobulin were investigated.ResultsGliSODin® reduced airway hyperresponsiveness, lung innate and adaptive immune response, and HDM-specific IgE production. Coculturing CD4+ T-cell with HDM-sensitized dendritic cells and GliSODin® reduced T-cell polarization into Th2 and Th17 cells. Moreover, adoptively transferred CD4+ T cells from asthmatic mice exhibited a reduced reactivation of Th2 and Th17 cells following stimulation with HDM plus GliSODin®.ConclusionGliSODin® abrogates asthma features and reduces CD4+ T-cell polarization and reactivation. Taken together, these data suggest that GliSODin® could be used for the management of asthma symptoms.

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Increased Oxidative Stress in Asthma—Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices

Cited by 10 publications

References 41 publications

Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review

Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review

Participation of reactive oxygen species in the pathogenesis of atopic dermatitis, allergic rhinitis and asthma

GliSODin® prevents airway inflammation by inhibiting T-cell differentiation and activation in a mouse model of asthma

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