Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery

Beck-Broichsitter, Moritz; Schweiger, Christoph; Schmehl, Thomas; Gessler, Tobias; Seeger, Werner; Kissel, Thomas

doi:10.1016/j.jconrel.2011.10.030

Cited by 126 publications

(67 citation statements)

References 42 publications

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“…Büchi (Switzerland) have been developing reliable and versatile spray dryers, which have been used for various intents [22][23][24][25][26][27]. Mini Spray Dryer B-290 and Nano Spray Dryer B-90 HP are two of those instruments and thus, their major characteristics and benefits are organized in Table 3 [22].…”

Section: Biomaterials -Physics and Chemistry -New Editionmentioning

confidence: 99%

“…Thus, a targeted delivery to the lungs enables the use of reduced doses, consequently minimizing the side effects associated with systemic drug administration [24,40]. Notwithstanding, this strategy implies the use of aerosol drugs, whose production is indeed feasible through the spray-drying technology.…”

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

“…Beck-Broichsitter et al [24] investigated the release profile of phosphodiesterase V (PDE-5) (a drug prescribed in the treatment of severe pulmonary hypertension) encapsulated within spray-dried polymeric particles. In that sense, they produced particles from organic PLGA solutions and also composite particles obtained from aqueous PLGA nanosuspensions.…”

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

See 2 more Smart Citations

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

102

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Spray drying is a well-known method of particle production which comprises the transformation of a fluid material into dried particles, taking advantage of a gaseous hot drying medium, with clear advantages for the fabrication of medical devices. In fact, it is quite common the production of microspheres and microcapsules designed for drug delivery systems. This review describes the different stages of the mechanism of the spray-drying process: atomization, droplet-to-particle conversion and particle collection. In particular, this work addresses the diversity of available atomizers, the drying kinetics and the importance of the configuration of the drying chamber, and the efficiency of the collection devices. The final properties of the dried products are influenced by a variety of factors, namely the spray dryer design, the feed characteristics and the processing parameters. The impact of those variables in optimizing both the spray-drying process and the synthesis of dried particles with desirable characteristics is discussed. The scalability of this manufacturing process in obtaining dried particles in submicron-to-micron scale favors a variety of applications within the food, chemical, polymeric, pharmaceutical, biotechnology and medical industries.

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Section: Biomaterials -Physics and Chemistry -New Editionmentioning

confidence: 99%

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

102

View full text Add to dashboard Cite

show abstract

“…6 A further report by Zvonar et al described use of a self-microemulsifying system to fabricate Ca-pectinate microcapsules to improve the release and permeability of furosemide. 7 Drug-loaded polymer microspheres have been variously prepared by phase separation, 8 interfacial polymerization, 9 spray-drying, 10 freeze-drying, 11 and emulsion evaporation. 12 However, these conventional strategies always either involve an intense operating process or preparation of particles with a wide particle size distribution and a relatively large amount of organic solvent residue.…”

Section: Introductionmentioning

confidence: 99%

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Chen¹,

Wang²,

Wang³

et al. 2012

IJN

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Background:The aim of this study was to improve the drug loading, encapsulation efficiency, and sustained-release properties of supercritical CO 2 -based drug-loaded polymer carriers via a process of suspension-enhanced dispersion by supercritical CO 2 (SpEDS), which is an advanced version of solution-enhanced dispersion by supercritical CO 2 (SEDS). Methods: Methotrexate nanoparticles were successfully microencapsulated into poly (L-lactide)-poly(ethylene glycol)-poly(L-lactide) (PLLA-PEG-PLLA) by SpEDS. Methotrexate nanoparticles were first prepared by SEDS, then suspended in PLLA-PEG-PLLA solution, and finally microencapsulated into PLLA-PEG-PLLA via SpEDS, where an "injector" was utilized in the suspension delivery system. Results: After microencapsulation, the composite methotrexate (MTX)-PLLA-PEG-PLLA microspheres obtained had a mean particle size of 545 nm, drug loading of 13.7%, and an encapsulation efficiency of 39.2%. After an initial burst release, with around 65% of the total methotrexate being released in the first 3 hours, the MTX-PLLA-PEG-PLLA microspheres released methotrexate in a sustained manner, with 85% of the total methotrexate dose released within 23 hours and nearly 100% within 144 hours. Conclusion: Compared with a parallel study of the coprecipitation process, microencapsulation using SpEDS offered greater potential to manufacture drug-loaded polymer microspheres for a drug delivery system.

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“…The HEL 12469 cells are human diploid (embryo) lung fibroblasts; these cells were used as a model of normal (healthy) tissue. We selected the human pulmonary cells because the lungs are the target organ by both occupational and public exposure to nanoparticles [18] and the inhalation therapy is a prospective non-invasive curative modality of lung cancer and other lung illnesses [14,19]. Inhalation therapy offers several advantages over systemic treatment.…”

mentioning

confidence: 99%

The intensity of internalization and cytotoxicity of superparamagnetic iron oxide nanoparticles with different surface modifications in human tumor and diploid lung cells

Mesárošová

Cĭampor²,

Závišová³

et al. 2012

neo

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The human lung adenocarcinoma epithelial (A549) cells and the human embryo lung (HEL 12469) cells were used to investigate the uptake and cytotoxicity of magnetite nanoparticles (MNPs) with different chemically modified surfaces. MNPs uptake was an energy-dependent process substantially affected by the serum concentration in the culture medium. Internalized MNPs localized in vesicle-bound aggregates were observed in the cytoplasm, none in the nucleus or in mitochondria. All MNPs induced a dose-and time-dependent increase in cytotoxicity in both human lung cell lines. The cytotoxicity of MNPs increased proportionally with the particle size. Since the cytotoxicity of MNPs was nearly identical when the doses were equalized based on particle surface area, we suppose that the particle surface area rather than the surface modifications per se underlay the cytotoxicity of MNPs. In general, higher internalized amount of MNPs was found in HEL 12469 cells compared with A549 cells. Accordingly, the viability of the human embryo lung cells was reduced more substantially than that of the adenocarcinoma lung cells. The weak MNPs uptake into A549 cells might be of biomedical relevance in cases where MNPs should be used as nanocarriers for targeted drug delivery in tumor tissue derived from alveolar epithelial cells.

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Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery

Cited by 126 publications

References 42 publications

Spray Drying: An Overview

Spray Drying: An Overview

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

The intensity of internalization and cytotoxicity of superparamagnetic iron oxide nanoparticles with different surface modifications in human tumor and diploid lung cells

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