Characterization of HCV genotype 4d infections in Kayseri, Turkey*

Kayman, Tuba; Polat, Ceylan; Ergör, Gül; Abacıoğlu, Yusuf Hakan

doi:10.3906/sag-1405-43

Cited by 7 publications

(16 citation statements)

References 33 publications

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“…In Turkey, genotype 4 distribution does not show high variability among the regions, ranging between 0.5% and 3.4% (Table 3), while a significant prevalence described only in Kayseri (32%) (13). By using molecular clock analysis, they predicted the introduction of type 4d HCV into the Kayseri region probably 30-75 years ago (26). The prevalence of genotype 3 is globally higher in the intravenous drug users (9).…”

Section: Discussionmentioning

confidence: 99%

Genotyping Distribution of Hepatitis C Virus in Şanlıurfa Province and Effect of Syrian Patients

Cirit¹,

Mizrakli²,

Vurupalmaz³

et al. 2019

vhd

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Amaç: Hepatit C virüsü (HCV), küresel ölüm ve morbiditenin başlıca nedenlerinden biridir. Çalışmamızın amacı Şanlıurfa'da HCV genotiplerinin dağılımını belirlemek, Suriye'den gelen hastaların HCV genotiplerinin dağılımı üzerindeki etkisini görmek ve sonuçları ülkemizdeki diğer bölgelerle karşılaştırmaktır. Gereç ve Yöntemler: Ocak 2011 ile Aralık 2015 arasında, toplam 312 (58'i Suriyeli hasta) HCV-RNA pozitif hepatit C hastasının serum örnekleri HCV genotiplendirme için laboratuvara gönderildi. HCV genotip analizi, ticari Abbott GT II (Abbott, ABD) kullanılarak araştırıldı. Bulgular: En sık rastlanan genotip; genotip 1 (%69,6), iken genotip 2 (%14,1) ve genotip 4 (%10,3) bunu takip etmekteydi. Suriyeli hastalar arasında en yaygın genotip; genotip 4 (%48,2) iken genotip 1 (%41,4), genotip 5 (%8,7) bunu takip etmekteydi. Verilerimiz 2011-2015 döneminde genotip 1 ve 2 prevalansının sırasıyla %75'ten %58,7'ye ve %21,2'den %12'ye düştüğünü, genotip 4 ve 5'in Suriyeli hastalar nedeniyle sırasıyla %1,9'dan %20'ye ve 0'dan %1,6'ya çıktığını göstermektedir. Sonuç: Güncellenen tahminlerimiz, özellikle Suriyeli hastalar nedeniyle Şanlıurfa'da genotip 4 ve genotip 5'teki artışı doğrulamaktadır. Anahtar Kelimeler: Hepatit C virüsü, genotip, göç, moleküler mikrobiyoloji Objectives: Hepatitis C virus (HCV) is one of the major causes of global mortality and morbidity. The purpose of our study was to characterize the distribution of HCV genotypes in Şanlıurfa, to see the effect of patients from Syria on the distribution of HCV genotypes and to compare our results with other regions in our country. Materials and Methods: Between January 2011 and December 2015, serum samples of 312 HCV-RNA positive patients (58 Syrian patients) were sent to the laboratory for HCV genotyping. HCV genotype analysis was investigated using a commercial Abbott GT II assay (Abbott, USA). Results: The most frequent genotype was genotype 1 (69.6%), followed by genotype 2 (14.1%) and genotype 4 (10.3%). Among Syrian patients, the most prevalent genotype was genotype 4 (48.2%), followed by genotype 1 (41.4%) and genotype 5 (8.7%). Our data showed that the prevalence of genotype 1 decreased from 75% to 58.7% and genotype 2 decreased from 21.2% to 12% between 2011 and 2015, while genotype 4 increased from 1.9% to 20% and genotype 5 increased from 0% to 1.6% due to the Syrian patients. Conclusion: Our updated estimates confirm an increase in genotype 4 and genotype 5, particularly in Şanlıurfa due to the Syrian patients.

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Section: Discussionmentioning

confidence: 99%

Genotyping Distribution of Hepatitis C Virus in Şanlıurfa Province and Effect of Syrian Patients

Cirit¹,

Mizrakli²,

Vurupalmaz³

et al. 2019

vhd

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“…Previous studies conducted in different localities of Turkey reported genotype 4 rates in the range 0.6–35.6% . The rates in Central Anatolia region were the highest; 28–35.6%, but still significantly lower (1.6%) than the rate detected in Aydin province (Table ).…”

Section: Discussionmentioning

confidence: 74%

“…Patients with genotype 4 were interestingly all males. In a study from Kayseri region, approximately two‐thirds of the patients infected with HCV genotypes 1 and 4 were female; however, most patients infected with genotype 2 were male .…”

Section: Discussionmentioning

confidence: 99%

“…It is mostly seen in India, Southeast Asia, and Indonesia and accounts for about 30% of the infected population in Europe, including Greece, Poland, and the Netherlands. In Turkey, the prevalence of genotype 3 significantly increased from 1.4% to 40% since 2007 (17,26,27). The highest prevalence was in Kahramanmaras with 40%, followed by Adana with 26%, Antalya with 11.1%, and Istanbul with 9.3% (16,28,31,32).…”

Section: Discussionmentioning

confidence: 99%

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Dynamics of HCV epidemiology in Aydin province of Turkey and the associated factors

Kırdar

Aydın

Tiryaki

et al. 2017

APMIS

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This paper gives an update on the local distributions of HCV genotypes in Aydin province of Turkey, provides a comparison with the previous records, and discusses the potential causal reasons shaping the evolving genotype profiles. Patient files from 2011 to 2016 were retrospectively analyzed, and newly detected cases were documented. Out of 286 patients, male and female ratios were determined to remain nearly the same (~50%). Genotype 1 was still the most common (90.2%), followed by genotype 3 (5.9%), genotype 2 (2.1%), and genotype 4 (1.4%) in frequency. There were international patients (4.50%). One patient had genotyped 2+3 together. Genotypes 4 and 2+3 were detected for the first time, and the patients with genotype 4 were interestingly all male and also domestic individuals. However, these patients traveled or lived abroad in the past due to occupational reasons, thereby likely acquired the infection while abroad. HCV surveillance system is currently inadequate and some infected patients may go undetected in the province. Remapping the regional distribution of HCV genotypes from time-to-time is required for identifying the local dynamics and causes leading to it. This process enhances the clinical preparation and readiness for the better management of the disease.

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“…This alteration may be due to immigrants, touristic activities and different risk factors for HCV infection, as well as increased safety procedures in medical practice. Table 4 shows the results of some of the HCV genotyping studies in Turkey (13,14,15,16,17,18,19,20,21,22,23,24,25,26,27).…”

Section: Discussionmentioning

confidence: 99%

Distribution of Hepatitis C Virus Genotypes in Aydın Province

Tiryaki¹,

Duran²,

Özçolpan³

2018

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Objectives: In this study, we evaulated the distribution and alteration of hepatitis C virus (HCV) genotypes throughout years which has a clinical importance in the treatment and follow-up. Materials and Methods: Test results obtained from blood samples sent to the molecular microbiology laboratory at Aydın State Hospital for HCV genotype determination were analyzed retrospectively. A total of 182 samples collected between 2014 and 2018 were enrolled in the study. The determination of genotype and viral load of the samples were performed by real time polymerase chain reaction. Results: 53.8% (98/182) of the samples were collected from male patients and 46.2% (84/182) from female patients. The mean age of the patients was 58.5±15.5 years. 69.2% of the samples were genotype 1b, 18.1%-genotype 1a, 2.2%-genotype 1 (those different from subtype 1a and 1b), 1.7%-genotype 2, 7.2%genotype 3, and 1.7% of the samples were genotype 4. Conclusion: In the present study, genotype 1 was the most common genotype (89.5%). Additionally, we have observed a decrease in the frequency of genotype 1b and a slightly increase in the frequency of other genotypes. Determination of HCV genotypes is important for treatment and prognosis of HCV infections.

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Characterization of HCV genotype 4d infections in Kayseri, Turkey*

Cited by 7 publications

References 33 publications

Genotyping Distribution of Hepatitis C Virus in Şanlıurfa Province and Effect of Syrian Patients

Genotyping Distribution of Hepatitis C Virus in Şanlıurfa Province and Effect of Syrian Patients

Dynamics of HCV epidemiology in Aydin province of Turkey and the associated factors

Distribution of Hepatitis C Virus Genotypes in Aydın Province

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