“…55 Several reviews have summarized the surface modifi cation methods of titanium and titanium alloys for biomedical applications. [47][48][49]56 They include mechanical methods such as machining, grinding, polishing, and sandblasting; 57-59 heat treatment; 60 chemical methods such as acid [61][62][63] and alkali etching, 42 anodization, 42,64 sintering, 65 and sol-gel; 56 chemical vapor deposition such as TiN, TiC, TiCN, [66][67][68] and diamond coatings; 69 and physical deposition such as plasma spraying, 47,70-77 laser deposition, [78][79][80] evaporation, 81 plasma treatment, [82][83][84] sputtering, [85][86][87][88][89][90][91] and ion implantation. [92][93][94][95][96][97][98][99][100][101] All these methods can be used to change the implant surface chemistry, morphology, and structure.…”