Enhancing osseointegration using surface-modified titanium implants

Yang, Yunzhi; Oh, Namsik; Liu, Y.; Chen, W.; Oh, Se Baek; Appleford, Mark R.; Kim, S.; Kim, K.; Park, S.; Bumgardner, Joel D.; Haggard, Warren O.; Ong, Joo L.

doi:10.1007/s11837-006-0146-1

Cited by 59 publications

(39 citation statements)

References 136 publications

(128 reference statements)

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“…[29][30][31][32] To achieve better bioactivity of Ti surfaces, HA has been used as a coating material on orthopedic and dental implants, which offered the possibility of combining the strength of the metals with the bioactivity of the ceramics. In addition to decreasing the metal ion release, 31 HA induced more rapid osseointegration, including direct bony growth and early mineralization at the interface, as well as equivalent or higher boneimplant bond strengths and percentage bone contact at the bone-implant interface compared to uncoated Ti implants.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and osteogenic properties of silver‐containing hydroxyapatite coatings produced using a sol gel process

Chen

Ong

et al. 2007

J Biomedical Materials Res

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Since bacterial infection is a rising complication following the wide use of implant, there is considerable attention on the effect of implant surface properties on bacterial adhesion. In this study, the effect of silver (Ag) doped hydroxyapatite (HA) coatings on initial antibacterial adhesion and osteoblast cell proliferation and differentiation was investigated. Using a sol-gel process, HA coatings doped with 1 wt % AgNO(3) (AgHA1.0) and 1.5 wt % Ag (AgHA1.5) were prepared. Coated surfaces were characterized using X-ray diffraction (XRD) and contact angles measurements. The initial bacteria adhesion was evaluated using a RP12 strain of Staphylococcus epidermidis (ATCC 35984) and the Cowan I strain of Staphylococcus aureus, whereas osteoblast proliferation and differentiation were evaluated using human embryonic palatal mesenchyme cells (HEPM), an osteoblast precursor cell line. In this study, XRD analysis of all surfaces indicated peaks corresponding to HA. Contact angles for AgHA surfaces were observed to be significantly lower when compared to HA surfaces. In vitro initial bacterial adhesion study indicated a significantly reduced number of S. epidermidis and S. aureus on AgHA surfaces when compared to HA surface. The use of HEPM cells indicated no significant difference in double-stranded DNA (dsDNA) production between all surfaces. Additionally, no differences in alkaline phosphatase specific activity were observed between HA and AgHA1.0 surfaces. Overall, it was concluded that AgHA1.0 has the similar biological activity as HA, with respect to bone cell proliferation and differentiation. In addition, the AgHA1.0 was also concluded to have the ability to minimize the initial bacteria adhesion. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007.

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Section: Discussionmentioning

confidence: 99%

Antibacterial and osteogenic properties of silver‐containing hydroxyapatite coatings produced using a sol gel process

Chen

Ong

et al. 2007

J Biomedical Materials Res

Self Cite

191

128

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“…Numerous researchers have realized that the existence of C-OH bond is beneficial towards hydrophilicity 52) . Typically, surface modification in dental implants, particularly in titanium implants, can enhance osseointegration and reduce healing time [53][54][55] . There is a close association between modified titanium surface and osteoblast cell adhesion, proliferation, differentiation and mineralization on its surface 56,57) .…”

Section: Discussionmentioning

confidence: 99%

A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An <i>in vitro</i> study

Guo

Zhou

et al. 2018

Dental Materials Journal

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Peri-implantitis is difficult to treat in clinical settings; this is not only because it is a site-specific infectious disease but also because it impedes osseointegration. In this study, a novel cold atmospheric pressure air plasma jet (CAPAJ) was applied to study the treatment of peri-implantitis in vitro. CAPAJ treated the samples for 2, 4 and 6 min, respectively. To evaluate the titanium surface characteristics, the surface elemental composition (X-ray photoelectron spectroscopy [XPS]), roughness and hydrophilicity were evaluated in each group. Concurrently, the sterilization and osseointegration effect of CAPAJ were also examined. Results revealed that after CAPAJ modification, roughness and hydrophilicity of titanium surfaces were significantly increased. Moreover, XPS results demonstrated that the C1s peak was reduced and N1s and O1s peaks were obviously improved. More importantly, CAPAJ showed favorable sterilization and bone formation effects. CAPAJ seemed a simpler and more efficient strategy for the peri-implantitis treatment.

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“…2.3.4 Oxide type By anodic oxidation it is possible to get amorphous or crystalline oxide depending upon the applied voltage and electrolyte used. Sulphuric acid anodization yields anatase at 90V, dual phase of anatase & rutile at 155V and rutile at 180V [27]. Anodic oxidation is carried out on titanium from electrolytes containing calcium acetates and glycerophosphates at voltages exceeding 250V [25][26].…”

Section: Compositionmentioning

confidence: 99%

“…The anodic oxide containing porous structure produces a rough surface and hence results in increased bone-toimplant contact and enhances the biomechanical interlocking of implant with bone at early times after placement to provide more bonding strength [27]. Primary fixation is one of the most important factors in establishing adequate osseointegration between bone and fixture.…”

Section: In Vivo Studiesmentioning

confidence: 99%

Electrochemical surface modification of titanium in dentistry

2009

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Titanium and its alloys have good biocompatibility with body cells and tissues and are widely used for implant applications. However, clinical procedures place more stringent and tough requirements on the titanium surface necessitating artificial surface treatments. Among the many methods of titanium surface modification, electrochemical techniques are simple and cheap. Anodic oxidation is the anodic electrochemical technique while electrophoretic and cathodic depositions are the cathodic electrochemical techniques. By anodic oxidation it is possible to obtain desired roughness, porosity and chemical composition of the oxide. Anodic oxidation at high voltages can improve the crystallinity of the oxide. The chief advantage of this technique is doping of the coating of the bath constituents and incorporation of these elements improves the properties of the oxide. Electrophoretic deposition uses hydroxyapatite (HA) powders dispersed in a suitable solvent at a particular pH. Under these operating conditions these particles acquire positive charge and coatings are obtained on the cathodic titanium by applying an external electric field. These coatings require a post-sintering treatment to improve the coating properties. Cathodic deposition is another type of electrochemical method where HA is formed in situ from an electrolyte containing calcium and phosphate ions. It is also possible to alter structure and/or chemistry of the obtained deposit. Nano-grained HA has higher surface energy and greater biological activity and therefore emphasis is being laid to produce these coatings by cathodic deposition.

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Enhancing osseointegration using surface-modified titanium implants

Cited by 59 publications

References 136 publications

Antibacterial and osteogenic properties of silver‐containing hydroxyapatite coatings produced using a sol gel process

Antibacterial and osteogenic properties of silver‐containing hydroxyapatite coatings produced using a sol gel process

A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An <i>in vitro</i> study

Electrochemical surface modification of titanium in dentistry

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