Characterization of flavonoids from Dryopteris erythrosora and evaluation of their antioxidant, anticancer and acetylcholinesterase inhibition activities

Cao, Ji; Xia, Xian; Chen, Xuefei; Xiao, Jianbo; Wang, Quanxi

doi:10.1016/j.fct.2012.09.039

Cited by 119 publications

(72 citation statements)

References 34 publications

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“…In spite of this, FRF obtained from B. forficata leaves, which showed strong antioxidant properties, did not exert any cytotoxic effect against the tumour cell lines tested; thus it can be assumed that flavonoids are not responsible for the cytotoxic activity of B. forficata crude extract, and that other different phytochemicals might act additively and/or synergistically to contribute to the observed effect. Our results are in agreement with those of other works, in which a weak relationship between antioxidant potential and cytotoxic activity of flavonoids was found (Cao et al 2013).…”

Section: Cytotoxic Activitysupporting

confidence: 96%

Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link. (Fabaceae) leaves extract

Miceli

Buongiorno

Celi

et al. 2015

Natural Product Research

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Bauhinia forficata Link. is utilised as an antidiabetic in Brazilian folk-medicine; furthermore, its antioxidant properties suggest a potential usefulness in the prevention of diabetes complications associated with oxidative stress. The contribution of a flavonoid-rich fraction (FRF), HPLC-PDA-ESI-MS characterised, to the antioxidant and cytotoxic properties of B. forficata hydro-alcoholic leaves extract was evaluated for the first time. Both extract and FRF showed radical-scavenging activity and reducing power with a strong relationship with the flavonoid content found; hence, flavonoids are mainly responsible for the primary antioxidant activity of B. forficata extract. The extract significantly decreased FO-1 cell viability at the higher concentrations. FRF did not exert any effect; thus, flavonoids do not appear to be responsible for the cytotoxicity of the extract. The extract resulted virtually non-toxic against both Artemia salina and normal human lymphocytes, demonstrating potential selectivity in inhibiting cancer cell growth. Finally, no antimicrobial activity was observed against the bacteria and yeasts tested.

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Section: Cytotoxic Activitysupporting

confidence: 96%

Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link. (Fabaceae) leaves extract

Miceli

Buongiorno

Celi

et al. 2015

Natural Product Research

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“…Fractions responsible for the antioxidant action were identified and seem promising for phytomedicinal development [7]. Recent advances have been made in scientific understanding of how berries promote human health and prevent chronic illnesses such as some cancers, heart disease, and neurodegenerative diseases [8].…”

Section: Introductionmentioning

confidence: 99%

“…The interactions between polyphenols, especially flavonoids and plasma proteins, have attracted great interest among researchers. Few papers, however, have focused on the structure–affinity relationship of polyphenols on their affinities for plasma proteins [7, 20, 21], especially from berries. We were interested to investigate relatively new kind of cape gooseberries ( P. peruviana ) and to compare its composition with that of the widely consumed blueberries and cranberries.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Studies on the Relationship Between the Antioxidant Activities of Some Berry Extracts and Their Binding Properties to Serum Albumin

Namieśnik

Vearasilp

Nemirovski

et al. 2014

Appl Biochem Biotechnol

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The aim of this study was to investigate the possibility to use the bioactive components from cape gooseberry (Physalis peruviana), blueberry (Vaccinium corymbosum), and cranberry (Vaccinium macrocarpon) extracts as a novel source against oxidation in food supplementation. The quantitative analysis of bioactive compounds (polyphenols, flavonoids, flavanols, carotenoids, and chlorophyll) was based on radical scavenging spectrophometric assays and mass spectrometry. The total phenolic content was the highest (P < 0.05) in water extract of blueberries (46.6 ± 4.2 mg GAE/g DW). The highest antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay and Cupric reducing antioxidant capacity were in water extracts of blueberries, showing 108.1 ± 7.2 and 131.1 ± 9.6 μMTE/g DW with correlation coefficients of 0.9918 and 0.9925, and by β-carotene linoleate assay at 80.1 ± 6.6 % with correlation coefficient of 0.9909, respectively. The water extracts of berries exhibited high binding properties with human serum albumin in comparison with quercetin. In conclusion, the bioactive compounds from a relatively new source of gooseberries in comparison with blueberries and cranberries have the potential as food supplementation for human health. The antioxidant and binding activities of berries depend on their bioactive compounds.

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“…can inhibit the growth and viability of the human glioblastoma cell line GL-15 [21]. The flavonoids from Dryopteris erythrosora have shown obvious cytotoxic effects on the lung cancer cell line A549 [22], and flavonoids from Korean Citrus aurantium L. can induced apoptosis in cell line A549 [23]. In this study, the total flavonoids from Elsholtzia densa Benth.…”

Section: Discussionmentioning

confidence: 96%

“…It was found that the inhibitory effect on proliferation of osteosarcoma MG-63 cells was enhanced when a combination of cisplatin and emodin was applied, due to emodin offsetting the cisplatininduced oxidative stress [25]. The flavonoids from Dryopteris erythrosora showed obvious cytotoxic effects on a lung cancer cell line (A549), and the anti-tumor activity was slightly increased with improving antioxidant potential of fern flavonoids [22]. Plant derived drugs are safer than synthetic medications, thus resulting in their wider utility.…”

Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> antioxidant, antibacterial and anti-tumor activities of total flavonoids from <i>Elsholtzia densa</i> Benth

Qiu-Rong¹,

Jiao²,

Wang³

et al. 2018

Trop. J. Pharm Res

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Characterization of flavonoids from Dryopteris erythrosora and evaluation of their antioxidant, anticancer and acetylcholinesterase inhibition activities

Cited by 119 publications

References 34 publications

Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link. (Fabaceae) leaves extract

Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link. (Fabaceae) leaves extract

In Vitro Studies on the Relationship Between the Antioxidant Activities of Some Berry Extracts and Their Binding Properties to Serum Albumin

<i>In vitro</i> antioxidant, antibacterial and anti-tumor activities of total flavonoids from <i>Elsholtzia densa</i> Benth

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