Characterization of cross-linked poly( N -isopropylmethacrylamide) microgel latexes

Duracher, David; Elaı̈ssari, Abdelhamid; Pichot, Christian

doi:10.1007/s003960050470

Cited by 87 publications

(77 citation statements)

References 2 publications

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“…This was achieved by preparing a microgel core and shell with a higher VPTT. pNIPMAM microgels are known to exhibit a VPTT around 45 • C [34]. It was used as a single monomer for the core and combined with a PBA-modified monomer for the shell.…”

Section: Insulin Delivery From Glucose-responsive Core-shell Microgelmentioning

confidence: 99%

Glucose-responsive microgels with a core–shell structure

Lapeyre

Ancla

Catargi

et al. 2008

Journal of Colloid and Interface Science

133

149

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Section: Insulin Delivery From Glucose-responsive Core-shell Microgelmentioning

confidence: 99%

Glucose-responsive microgels with a core–shell structure

Lapeyre

Ancla

Catargi

et al. 2008

Journal of Colloid and Interface Science

133

149

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“…1, 2, 5, 7 Particles composed of poly(N-isopropylmethacrylamide) (pNIPMAm) behave in a similar manner, exhibiting an LCST around 44 °C, with the increased LCST arising from an increase in the rigidity of the pNIPMAm polymer, as is common for methacrylamides. [25][26][27][28][29] This behavior is important to this work due to the fact that our group has optimized core/shell nanogel synthesis techniques that utilize this LCST behavior to drive the controlled nucleation and growth of the particles.…”

Section: Introductionmentioning

confidence: 99%

Size-controlled synthesis of monodisperse core/shell nanogels

2007

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Small, monodispersed nanogels (~ 50-nm radius) were synthesized by free-radical precipitation polymerization and characterized using a suite of light scattering and chromatography methods. Nanogels were synthesized with either N-isopropylacrylamide or N-isopropylmethacrylamide as the main monomer, with acrylic acid or 4-acrylamidofluorescein as a co-monomer and N, N′-methylenebis(acrylamide) as a cross-linker. By varying the surfactant and initiator concentrations, particle size was controlled while maintaining excellent monodispersity. An amine-containing shell was added to these core particles to facilitate subsequent bioconjugation. Successful conjugation of folic acid to the particles was demonstrated as an example of how such materials might be employed in a targeted drug delivery system.

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“…have primarily been presented and discussed, [10][11][12] while there have been few reports on the influence of the initiator on the polymerization process. 13 As expected, the initiator plays an important role in the polymerization process, especially during the nucleation period, and consequently, on the final microgel properties. The role of the initiator in the formation of PNIPAM microgels can be considered as follows: (1) it initiates the polymerization of the monomer and the crosslinker in the water phase leads to the formation of oligomers, which are precipitated to produce precursor particles when their critical chain lengths are reached or when the crosslinked chains start to precipitate; (2) its decomposed fragments confer the special charged groups on the surfaces of PNIPAM microgels, which endow the microgels with some applications, such as temperature-sensitive colloidal crystals, separation of bioactive substances, carrier of the reagent for medical test, etc.…”

Section: Introductionmentioning

confidence: 85%

Synthesis and colloidal stability of poly(N‐isopropylacrylamide) microgels with different ionic groups on their surfaces

Zha

Bao

2006

J of Applied Polymer Sci

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Temperature-sensitive poly(N-isopropylacrylamide) (PNIPAM) microgels with sulfate, amidino, or carboxylic groups on their surfaces, were synthesized by precipitation polymerization based on ammonium persulfate (APS), 2,2 0 -azobis(amidinopropane) dihydrochloride (V50), or 4,4 0 -azobis(4-cyanovaleric acid) (ACVA) as initiator, respectively. Their particle sizes and swelling ratios depended on the reaction pH due to the pH dependence of the ionization degree of the decomposed fragments originating from the initiators and their hydrophilicityhydrophobicity. The more hydrophobic initiators partitioned into the interior of the PNIPAM microgels under certain pH conditions initiated the crosslinking reaction between the PNIPAM chains, leading to higher crosslinking density of the microgels resulting in their smaller swelling ratio. pH dependence of surface charge density of the microgels with amidino groups or carboxylic acid groups on their surfaces was evidenced by the variation of their zpotentials as a function of pH. Correspondingly, due to their pH dependence of electrostatic repulsive effect, the colloidal stability of the microgels with amidine groups or carboxylic acid groups on their surfaces was dependent on the pH value of dispersion medium.

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Characterization of cross-linked poly( N -isopropylmethacrylamide) microgel latexes

Cited by 87 publications

References 2 publications

Glucose-responsive microgels with a core–shell structure

Glucose-responsive microgels with a core–shell structure

Size-controlled synthesis of monodisperse core/shell nanogels

Synthesis and colloidal stability of poly(N‐isopropylacrylamide) microgels with different ionic groups on their surfaces

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