Glucose-responsive microgels with a core–shell structure

Lapeyre, Véronique; Ancla, Christophe; Catargi, Bogdan; Ravaine, Valérie

doi:10.1016/j.jcis.2008.08.039

Cited by 133 publications

(159 citation statements)

References 33 publications

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“…The shelling process was repeated to obtain a thicker layer of the PNIPAm shell. Monodispersed PNIPAm-APBA submicrometric microgel particles with a well-controlled size were also prepared by polymerization through precipitation by Lapeyre et al [20,21]. In their case, they first prepared PNIPAm core microgels by an aqueous free radical polymerization through precipitation.…”

Section: Resultsmentioning

confidence: 99%

“…Degradable multifunctional [15] and injectable dextran [16] containing microgels composed of glucose-responsive PBA of several hundred nanometers in diameter were synthesized and studied for insulin loading and levels of release in response to glucose. PNIPAm, APBA, and its copolymers have also been studied by many research groups [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Semibath Polymerization Approach for One-Pot Synthesis of Temperature- and Glucose-Responsive Core-Shell Nanogel Particles

Khan

El‐Toni

Alam

et al. 2018

Journal of Nanomaterials

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Herein, we report a simple and easy procedure for the synthesis of core-shell structures of glucose-sensitive 3-acrylamidophenylboronic acid (APBA) and temperature-responsive P(NIPAm-AAc) shell nanogel particles using MBA as a cross-linker via free radical polymerization. The synthesized particles were approximately 100 nm and were cross-linked to one another. The shell thickness of the nanogel particles was adjusted by increasing the concentrations of NIPAm through the semibath approach during the process of polymerization. The synthesized colloidal nanogel particle shows thermoresponsive behaviors. The dynamic light scattering technique also confirmed the change in the size of particles dispersed in an aqueous solution upon increase/decrease in temperatures, which is the result of its volume phase transition temperatures (VPTT). The size and morphology of the particles were characterized by TEM, FE-SEM, and AFM. The sensitivity of these nanogel particles to temperature and glucose suggests that they have the potential for applications related to the delivery of self-regulated insulin.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Semibath Polymerization Approach for One-Pot Synthesis of Temperature- and Glucose-Responsive Core-Shell Nanogel Particles

Khan

El‐Toni

Alam

et al. 2018

Journal of Nanomaterials

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“…Degradation of the microgel core induces rupture of the coated films, resulting in release of the encapsulated materials. Lapeyre et al synthesized core-shell microgels with a thermoresponsive poly(N-isopropylacrylamide) core and a glucose-responsive poly(N-isopropylacrylamide)-coacrylamidophenylboronic acid shell [10]. Initially, the shell suppresses core swelling over a certain temperature range.…”

Section: Pressure-induced Drug Release From Gelmentioning

confidence: 99%

Emerging pressure-release materials for drug delivery

Ariga

Kawakami

Hill

2013

Expert Opinion on Drug Delivery

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“…They further modified this system into a core/shell configuration with a thermoresponsive core and a glucose-responsive shell for glucosedependent insulin delivery. [52] In a different example, Uragami and coworkers have developed glycoprotein-responsive acrylamide hydrogels grafted with lectins and antibodies, ligands for saccharide and peptide chains in the target glycoprotein, that were used in molecular imprinting of the hydrogels. The imprinted hydrogels collapsed specifically in the presence of the glycoprotein due to the crosslinks formed from the lectinglycoprotein-antibody complex.…”

Section: Dynamic Hydrogels Based On Competitive Interactionsmentioning

confidence: 99%

Bioinspired Design of Dynamic Materials

2009

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An emerging approach for design of dynamic materials involves mimicking natural systems, which are adept at changing their structure and function in response to their environment. Biological systems possess a diverse range of dynamic mechanisms, including competitive ligand–protein binding, enzyme‐catalyzed remodeling, and allosteric protein conformational changes. These dynamic mechanisms are now being exploited by materials scientists and engineers to design “bioinspired” synthetic materials that undergo responsive assembly and disassembly as well as dynamic volume and shape changes. The purpose of this review is to describe recent progress in design and development of bioinspired dynamic materials, with a particular emphasis on hydrogel networks. We specifically focus on emerging approaches that use biological phenomena as an inspiration for design of materials.

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Glucose-responsive microgels with a core–shell structure

Cited by 133 publications

References 33 publications

Semibath Polymerization Approach for One-Pot Synthesis of Temperature- and Glucose-Responsive Core-Shell Nanogel Particles

Semibath Polymerization Approach for One-Pot Synthesis of Temperature- and Glucose-Responsive Core-Shell Nanogel Particles

Emerging pressure-release materials for drug delivery

Bioinspired Design of Dynamic Materials

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