Characterization of beta-cyclodextrin inclusion complexes containing essential oils (trans-cinnamaldehyde, eugenol, cinnamon bark, and clove bud extracts) for antimicrobial delivery applications

β-Cyclodextrins as Encapsulating Agents of Essential Oils

“…Another characteristic of these compounds is the safety of their use in food. Many essential oils are considered by the Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS), meaning that they can be used in food products without the need for approval via technical analysis [21].…”

“…However, its high cost and long process time reduce its applicability [64]. Examples of studies that used this technique include Calvo et al [90] who microencapsulated extra virgin olive oil in the presence of maltodextrin, carboxymethylcellulose, and lecithin; Ezhilarasi et al [91], who studied microencapsulation of garcinia fruit extract by spray drying and its effect on bread quality; Piletti et al [19], who encapsulated eugenol essential oil into β-cyclodextrin molecules through lyophilization; and Hill et al [21], who encapsulated cinnamon bark extract, trans-cinnamaldehyde, clove extract, eugenol, and a 2:1 mixture (transcinnamaldehyde: eugenol) with β-cyclodextrin using the lyophilization method.…”

“…These inclusion complexes are relatively more hydrophilic and larger in size than the non-associated active compound, which helps to increase the retention of the encapsulated substance. They are also very interesting because they can mask undesirable flavors and odors that the encapsulated compounds may present [21,56,72,101,102,[106][107][108][109][110].…”

“…Hill et al [21] investigated the complexes formed by oils encapsulated in β-cyclodextrin (BCD) and their antimicrobial activity. The natural products studied were cinnamon bark extract, trans-cinnamaldehyde, clove bud extract, eugenol, and a 2:1 (trans-cinnamaldehyde:eugenol) mixture microencapsulated with the freeze-drying method.…”

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“…The solvent was evaporated under the vacuum, and good quality of cyclodextrin inclusion complexes was obtained. [113,121] Many essential oils (such as cinnamon, clove, [122] estragole, [123] black pepper oil, [124] thymol, [109] Kamebakaurin, [125] and chloramphenicol) [126] were encapsulated by the formation of inclusion complexes with cyclodextrins. [111] …”