Characterization of an antithrombotic peptide from α-casein in newborn plasma after milk ingestion

Chabance, Béatrice; Jollès, Pierre; Izquierdo, Carmen; Mazoyer, E.; Francoual, C; Drouet, Ludovic; Fiat, Anne‐Marie

doi:10.1079/bjn19950060

Cited by 140 publications

(72 citation statements)

References 16 publications

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“…Numerous bioactive peptides which are identified in milk protein may be released after enzymatic digestion (Meisel, 1997;Clare and Swaisgood, 2000). The functional peptides from milk showed many physiological effects, such as calcium biotransfer activity (Lee et al, 1979), opiate activity (Meisel and FitzGerald, 2000), immunomodulating activity (Pitt et al 1974;Totima et al, 1994), anti-hypertensive activity (Maruyama et al, 1987), and anti-thrombotic activity (Chabance et al, 1995). The a s1 -CH has also been reported to exhibit a benzodiazepine (BDZ)-like activity of the GABA A receptor without side effects (Miclo et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of αs1-casein hydrolysate on stress-related symptoms in women

Kim

Desor

Kim³

et al. 2006

Eur J Clin Nutr

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Objective: To examine the effects of a s1 -casein hydrolysate on females with stress-related symptoms. Design: Double-blind, randomized, crossover, placebo-controlled trial. Setting: The a s1 -casein hydrolysate was manufactured by INGREDIA (Arras, France) and the placebo was manufactured by DIETAROMA (Bourg, France). Study was designed and performed at PROCLAIM (Rennes, France), and the statistical analyses were performed by D Desor (Nancy, France). Subjects: A total of 63 female volunteers suffering from at least one disorder that may be related to stress such as anxiety, sleep problems and general fatigue. Interventions: A total of 63 volunteers participated in a double-blind, randomized, crossover, placebo-controlled study. Subjects were randomly allocated to receive either tablets containing a s1 -casein hydrolysate or placebo at the dose of 150 mg/ day for 30 days. After a 3 weeks washout period, they were crossed over for a new 30-day period of tablets intake. The outcome measure was a questionnaire including 44 items of symptoms that may be related stress in which the severity of each sign was evaluated using a 10-degree scale. These measures were studied repeatedly at the day of 0, 15 and 30 after the start of each interventional period. Results: The 30-day treatment by a s1 -casein hydrolysate in females with stress-related symptoms reduced their symptoms, particularly in digestion (Po0.01), cardiovascular (Po0.05), intellectual (Po0.01), emotional (Po0.05) and social problems (Po0.05). Conclusion: This study showed that a 30-day ingestion of a s1 -casein hydrolysate decreased the stress-related symptoms in females suggesting that this product may be used as an effective functional ingredient alleviating such symptoms.

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Section: Discussionmentioning

confidence: 99%

Efficacy of αs1-casein hydrolysate on stress-related symptoms in women

Kim

Desor

Kim³

et al. 2006

Eur J Clin Nutr

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“…Indeed, even if many of these reports are only anecdotal, several milk components, like tryptophan (precursor of serotonin, a neurotransmitter involved in sleep induction), can act upon sleep and magnesium [60,61]. More recently, a lot of bioactive peptides released during enzymatic digestion of milk proteins have revealed various interesting properties like calcium bio-transfer activity [62], opiate activity [63], immunomodulating activity [64,65], anti-hypertensive activity [66] and anti-thrombotic activity [67]. CTH, a milk S1-casein tryptic hydrolysate, has shown interesting properties (reduction of systolic blood pressure reaction and of cortisol increase) in healthy human volunteers facing mental and physical stress situations [45].…”

Section: Discussionmentioning

confidence: 99%

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Saint-Hilaire¹,

Messaoudi²,

Desor³

et al. 2009

TOSLPJ

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This study describes the effect of bovine alpha-S1 casein tryptic hydrolysate (CTH) in a representative sample of day-time workers from the general population of Japan with the occurrence of insomnia during the preceding six months. To investigate this issue, 32 subjects, aged between 25 and 40 years, were examined for the subjective sleep quality using the Japanese Pittsburg Sleep Quality Index (PSQI-J).CTH significantly improves the PSQI total score of the treated subjects. It particularly improves the sleep quality after two weeks of treatment, decreases the sleep latency and the daytime dysfunction after four weeks of treatment.Given the antistress properties of CTH, it seems possible to relate the detected improvement of sleep aspects to a reduction of stress following its' chronic administration.In conclusion, being given its beneficial effects and its absence of negative side effects, it would be advantageous to use the CTH to improve chronic insomnia in the Japanese general population. However, further studies will be necessary in order to clarify the essential aspect of CTH properties in the sleep problems.

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“…However, blood coagulation and clot formation are considered undesirable circumstances in some medical conditions and therefore, antithrombotic agents, especially natural ones, are favored. In this regard, bioactive peptides have been found to have antithrombotic effect (Jolles et al, 1986;Raha et al, 1988;Mazoyer et al, 1990;Chabance et al, 1995;Morimatsu et al, 1996;Shimizu et al, 2009). There are two types of antithrombotic agents: anticoagulants and antiplatelets.…”

Section: Antithrombotic Activitiesmentioning

confidence: 99%

Peptides: Production, bioactivity, functionality, and applications

Hajfathalian

Ghelichi

Moreno

et al. 2017

Critical Reviews in Food Science and Nutrition

133

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Production of peptides with various effects from proteins of different sources continues to receive academic attention. Researchers of different disciplines are putting increasing efforts to produce bioactive and functional peptides from different sources such as plants, animals, and food industry by-products. The aim of this review is to introduce production methods of hydrolysates and peptides and provide a comprehensive overview of their bioactivity in terms of their effects on immune, cardiovascular, nervous, and gastrointestinal systems. Moreover, functional and antioxidant properties of hydrolysates and isolated peptides are reviewed. Finally, industrial and commercial applications of bioactive peptides including their use in nutrition and production of pharmaceuticals and nutraceuticals are discussed.

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Characterization of an antithrombotic peptide from α-casein in newborn plasma after milk ingestion

Cited by 140 publications

References 16 publications

Efficacy of αs1-casein hydrolysate on stress-related symptoms in women

Efficacy of αs1-casein hydrolysate on stress-related symptoms in women

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Peptides: Production, bioactivity, functionality, and applications

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