Efficacy of αs1-casein hydrolysate on stress-related symptoms in women

Abstract

Objective: To examine the effects of a s1 -casein hydrolysate on females with stress-related symptoms. Design: Double-blind, randomized, crossover, placebo-controlled trial. Setting: The a s1 -casein hydrolysate was manufactured by INGREDIA (Arras, France) and the placebo was manufactured by DIETAROMA (Bourg, France). Study was designed and performed at PROCLAIM (Rennes, France), and the statistical analyses were performed by D Desor (Nancy, France). Subjects: A total of 63 female volunteers suffering from at least one disorder that may be related to stress such as anxiety, sleep problems and general fatigue. Interventions: A total of 63 volunteers participated in a double-blind, randomized, crossover, placebo-controlled study. Subjects were randomly allocated to receive either tablets containing a s1 -casein hydrolysate or placebo at the dose of 150 mg/ day for 30 days. After a 3 weeks washout period, they were crossed over for a new 30-day period of tablets intake. The outcome measure was a questionnaire including 44 items of symptoms that may be related stress in which the severity of each sign was evaluated using a 10-degree scale. These measures were studied repeatedly at the day of 0, 15 and 30 after the start of each interventional period. Results: The 30-day treatment by a s1 -casein hydrolysate in females with stress-related symptoms reduced their symptoms, particularly in digestion (Po0.01), cardiovascular (Po0.05), intellectual (Po0.01), emotional (Po0.05) and social problems (Po0.05). Conclusion: This study showed that a 30-day ingestion of a s1 -casein hydrolysate decreased the stress-related symptoms in females suggesting that this product may be used as an effective functional ingredient alleviating such symptoms.

Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs

“…Results from questionnaire-based studies show that a s1 -casein hydrolysate may be used as an effective functional ingredient alleviating stress-related symptoms after 30 days of administration in women (Kim et al, 2007) and after 56 days in cats (Beata et al, 2007). Our results showed that a CH diet administered for a period of 65 days reduced some stress-related indicators in dogs.…”

“…Several of the parameters used in this study have been reported to characterize the different components of a stress reaction: questionnaires (Kim et al, 2007), endocrine assay (Ilardo et al, 2001) and physiological measurements (Boiten et al, 1994;Larson et al, 2001).…”

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

“…In healthy human volunteers, this tryptic hydrolysate showed anxiolytic-like effects, without side effects, on the basis of hemodynamic parameters under mentally and physically stressful situations [45]. A recent study showed that a 30-day ingestion of S1-casein tryptic hydrolysate decreased stress-related symptoms in women, particularly in digestive, cardiovascular, intellectual, emotional and social problems [46]. Thus, considering the deleterious link between stress, anxiety and sleep, we hypothesized that this S1-casein hydrolysate might also prevent or reduce the effects of stressful environmental conditions on sleep.…”

Les 10es Entretiens de nutrition, institut Pasteur de Lille L’obésité, une maladie nutritionnelle ?

“…Des peptides fonctionnels issus du lait tels que l'alpha-lactalbumine et l'alpha-1 caséine peuvent amélio-rer les performances cognitives de sujets vulnérables au stress [55] et les symptômes liés au stress [56]. Le recours aux méthodes de relaxation, de yoga, de sophrologie ou de méthodes apparentées (Vittoz) pourrait s'avérer utile.…”