Characterization of a novel B(A) allele with BBBA type at the ABO blood group

Deng, Zhihui; Yu, Qi; Wang, Da-Ming; Su, Yubin; Wu, Guo-Guang

doi:10.1007/s10038-006-0013-5

Cited by 10 publications

(4 citation statements)

References 17 publications

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“…In fact, the distinction between the two alleles has no clinical implication. The ABO*cisAB.05 and ABO*BA.06 alleles have been reported only in one Chinese subject with an A 2 B phenotype [4,14]. However, B(A) blood group types and ABO*cisAB.05 allele have never been confirmed by molecular analysis, although other alleles of cis-AB blood group, such as ABO*cisAB.01 and ABO*cisAB.04, have been reported in Korean and Japanese populations [12].…”

Section: Discussionmentioning

confidence: 94%

Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A₂B Phenotype

Yu¹,

Chung

Kim

et al. 2020

KJBT

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Cis-AB and B(A) alleles encode an ABO enzyme with dual A and B glycosyltransferase activity. Although globally rare, the cis-AB phenotype is found relatively often in Korean, Japanese, and Chinese populations. Cases of the B(A) allele have been reported mostly in the Chinese population. Forward typing performed in a Cambodian woman with an ABO discrepancy demonstrated a strong reaction with anti-A and anti-B reagents, while there was no reaction with lectin anti-A1. The anti-A1 antibody was detected in reverse typing. Through ABO gene sequence analyses of exons 6 and 7, one of the alleles was identified as ABO*B.01. In contrast, the other allele harboring a c.803G＞C substitution was either ABO*cisAB.05 or ABO*BA.06 allele. The ABO*cisAB.05 and ABO*BA.06 alleles remain indistinguishable despite routine serological testing and ABO genotyping. To the best of the author's knowledge, this is the first case report of these variants discovered in a Cambodian individual residing in Korea.

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Section: Discussionmentioning

confidence: 94%

Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A₂B Phenotype

Yu¹,

Chung

Kim

et al. 2020

KJBT

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“…To date, eleven classifications of ABO*cisAB alleles presenting various cisAB phenotypes have been reported globally [14]. Four amino acid positions (p.Arg176Gly, p.Gly235Ser, p.Leu266Met, and p.Gly268Ala) were found critical in altering the specificity of transfer from GTA (A-synthesizing α1-3 N-acetylgalactosaminyltransferase) to GTB (B-synthesizing α1-3 galactosyltransferase) [16]. One of the very earliest studies by Yamamoto et al identified an allele that differs from A1.02 by one variant c.803G>C (p.Gly268Ala) results in an A antigen exhibiting B antigen features which leads to mistyping of ABO grouping [17].…”

Section: Discussionmentioning

confidence: 99%

Insights into the Rare cis-AB Blood Group: In Silico Genotyping and Analysis in the Indian Subcontinent

Rophina¹,

Scaria²,

Datta³

2023

Preprint

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The rare blood groups reported from India include the Bombay phenotype, -D-/-D-, In (a+b-) and other weaker variants of ABH antigens. We report a case of cis-AB blood group, identified in an Indian patient whose blood grouping was performed by the column agglutination technique, conventional tube technique (CTT) after 15 minutes of incubation at room temperature as well as at 40C and subsequently whole exome sequencing for molecular analysis. The blood group was identified serologically as A2B3 and confirmed to be a cisAB phenotype by next-generation sequencing.

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“…In this study, the results of cross-matching were negative in all pairs ( Table 1 ). Specifically, we examined ABO blood groups because they are the critical determinant of transfusion incompatibility in humans; blood type is determined from allelic variation at the ABO gene, which encodes a glycosyltransferase [ 25 , 26 ]. We found only type A among our marmoset samples, corroborating previous reports at three marmoset facilities that the primates were all type A [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Whole blood transfusion in common marmosets: a clinical evaluation

et al. 2022

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In veterinary medicine, blood transfusion is commonly performed on companion animals. The common marmoset is a small nonhuman primate with increasing popularity as an animal model in biomedical research. Because of its small whole blood volume, the marmoset is at high risk of exsanguination, and blood transfusion is required to care for life-threatening bleeding. However, few clinical evaluations exist on transfusions for marmosets. This study performed whole blood transfusion with cross-matching on nine marmosets and surveyed the therapeutic effects. Recipients included clinical cases with persistent bleeding, anemia, and coma, as well as animals subjected to postoperative bleeding prophylaxis. Donors were selected from healthy marmosets, including littermates. Cross-match assay before transfusion were all negative, and recipients showed no visible signs of transfusion-related adverse reactions. Whole blood transfusions caused hemostasis and successful recovery in bleeding marmosets, including long-term improvement of anemia cases. Our results indicated that blood transfusion is effective for marmosets with severe anemia and persistent hemorrhage from both non-experimental and surgical causes. Furthermore, DNA sequencing for blood-group classification revealed that all subject marmosets were type A, suggesting that the risk of blood type mismatch may be low in this species.

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Characterization of a novel B(A) allele with BBBA type at the ABO blood group

Cited by 10 publications

References 17 publications

Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A₂B Phenotype

Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A₂B Phenotype

Insights into the Rare cis-AB Blood Group: In Silico Genotyping and Analysis in the Indian Subcontinent

Whole blood transfusion in common marmosets: a clinical evaluation

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Characterization of a novel B(A) allele with BBBA type at the ABO blood group

Cited by 10 publications

References 17 publications

Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A2B Phenotype

Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A2B Phenotype

Insights into the Rare cis-AB Blood Group: In Silico Genotyping and Analysis in the Indian Subcontinent

Whole blood transfusion in common marmosets: a clinical evaluation

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Product

Resources

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Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A₂B Phenotype

Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A₂B Phenotype