Characterization and potential applications of gamma irradiated chitosan and its blends with poly(vinyl alcohol)

Bano, Ijaz; Ghauri, Muhammad Afzal; Yasin, Tariq; Huang, Qingrong; Palaparthi, Annie D'Souza

doi:10.1016/j.ijbiomac.2014.01.015

Cited by 50 publications

(18 citation statements)

References 48 publications

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“…For the as-received materials, the intensities are much lower compared to those of the composite films. The increase of the band intensities in the composite films is expected to be due to the introduction of additional group into the composite blends, which is in agreement with the results found by others [23], [24].…”

Section: Characterizationsupporting

confidence: 91%

Characteristics of Mixed Polyvinyl Alcohol and Chitosan Obtained from Shrimp Shells and Squid Pens for Electromagnetic Wave Absorber

Sofyan¹,

Sany²,

Yuwono³

et al. 2017

IJET

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Abstract-One of the potential materials developed for electromagnetic interference shielding and or anti radio detecting and ranging (radar) purposes is chitosan, however, its capability to absorb the electromagnetic waves needs to be characterized. This work aims at studying the characteristics of polyvinyl alcohol (PVA mixed with) -chitosan obtained from shrimp shells and β-chitosan obtained from squid pens for electromagnetic wave absorber. Samples were prepared with weight ratio variation of chitosan from each source at 0.5, 1, 1.5 and 2 wt.% and homogenously mixed with 8 wt.% of PVA. The solution mixture was casted into a petri dish through solution casting methods. The samples were characterized by using thickness measurer for the thickness, scanning electron microscope (SEM) for microstructure and surface morphology, X-ray powder diffractometer (XRD) for phase identification, Fourier transform infra-red spectroscopy (FTIR) for functional groups, and network analyser to measure the reflection loss characteristics. The electromagnetic wave absorption characteristics show that α-chitosan has an absorption intensity with minimum value of -14.92 dB at 2.0 wt.% α-chitosan and maximum value of -31.03 dB at 0.5 wt.% α-chitosan. Similarly, β-chitosan showed an absorption intensity with minimum value of -15.48 dB at 2.0 wt.% β-chitosan and maximum value of -31.94 dB at 0.5 wt.% β-chitosan. These trends show that the materials have a potential to be further developed for anti-radar capability.

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Section: Characterizationsupporting

confidence: 91%

Characteristics of Mixed Polyvinyl Alcohol and Chitosan Obtained from Shrimp Shells and Squid Pens for Electromagnetic Wave Absorber

Sofyan¹,

Sany²,

Yuwono³

et al. 2017

IJET

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show abstract

“…[3]. PVA is a synthetic, water soluble, non-toxic [105], hydrophilic, biocompatible, biodegradable [106], non-carcinogenic [107] polymer with good mechanical properties. Due to the above mentioned positive attributes, it is being used in different biomedical applications [108] such as tissue engineering and drug delivery [109].…”

Section: Base Materials For Ph Sensitive Hydrogelsmentioning

confidence: 99%

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

et al. 2017

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Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pK a and pK b values on the ionization, consequent swelling, and targeted drug release are also highlighted.

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“…Unfortunately, gamma irradiation can induce degradation effect by chain scission of synthetic and natural polymers usually employed as carriers [ 24 , 25 ]. Feasibility of using gamma irradiation as a sterilization procedure is therefore necessary when each compound for changes in biological activity or for induction of harmful products is applied.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of a Gamma Irradiated DBM-Pluronic F127 Composite on Bone Regeneration in Wistar Rat

et al. 2015

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Demineralized bone matrix (DBM) is widely used for bone regeneration. Since DBM is prepared in powder form its handling properties are not optimal and limit the clinical use of this material. Various synthetic and biological carriers have been used to enhance the DBM handling. In this study we evaluated the effect of gamma irradiation on the physical-chemical properties of Pluronic and on bone morphogenetic proteins (BMPs) amount in DBM samples. In vivo studies were carried out to investigate the effect on bone regeneration of a gamma irradiated DBM-Pluronic F127 (DBM-PF127) composite implanted in the femur of rats. Gamma irradiation effects (25 kGy) on physical-chemical properties of Pluronic F127 were investigated by rheological and infrared analysis. The BMP-2/BMP-7 amount after DBM irradiation was evaluated by ELISA. Bone regeneration capacity of DBM-PF127 containing 40% (w/w) of DBM was investigated in transcortical holes created in the femoral diaphysis of Wistar rat. Bone porosity, repaired bone volume and tissue organization were evaluated at 15, 30 and 90 days by Micro-CT and histological analysis. The results showed that gamma irradiation did not induce significant modification on physical-chemical properties of Pluronic, while a decrease in BMP-2/BMP-7 amount was evidenced in sterilized DBM. Micro-CT and histological evaluation at day 15 post-implantation revealed an interconnected trabeculae network in medullar cavity and cellular infiltration and vascularization of DBM-PF127 residue. In contrast a large rate of not connected trabeculae was observed in Pluronic filled and unfilled defects. At 30 and 90 days the DBM-PF127 samples shown comparable results in term of density and thickness of the new formed tissue respect to unfilled defect. In conclusion a gamma irradiated DBM-PF127 composite, although it may have undergone a significant decrease in the concentration of BMPs, was able to maintains bone regeneration capability.

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Characterization and potential applications of gamma irradiated chitosan and its blends with poly(vinyl alcohol)

Cited by 50 publications

References 48 publications

Characteristics of Mixed Polyvinyl Alcohol and Chitosan Obtained from Shrimp Shells and Squid Pens for Electromagnetic Wave Absorber

Characteristics of Mixed Polyvinyl Alcohol and Chitosan Obtained from Shrimp Shells and Squid Pens for Electromagnetic Wave Absorber

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

Evaluation of the Effect of a Gamma Irradiated DBM-Pluronic F127 Composite on Bone Regeneration in Wistar Rat

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