Characteristics of Sebaceous Carcinoma and Early Outcomes of Treatment Using Mohs Micrographic Surgery Versus Wide Local Excision: An Update of the Mayo Clinic Experience Over the Past 2 Decades

Hou, Jennifer L.; Killian, Jill M.; Baum, Christian L.; Otley, Clark C.; Roenigk, Randall K.; Arpey, Christopher J.; Weaver, Amy L.; Brewer, Jerry D.

doi:10.1111/dsu.12433

Cited by 36 publications

(25 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mohs micrographic surgery and wide local excision were equally effective in terms of outcomes, and either could therefore be pursued in the organ transplant population. This is consistent with a previous study in nontransplant recipi‐ents, in which Mohs micrographic surgery and wide local excision were equally effective …”

Section: Discussionsupporting

confidence: 93%

“…We found 50% of the tumors tested to have microsatellite instability; none of these patients, however, were exposed to azathioprine. While a previous study proposed that azathioprine may interact with DNA MMR proteins and lead to microsatellite instability, this was not seen in our one tumor from a patient exposed to azathioprine . In our three cases that had microsatellite instability, it is possible that tacrolimus or mycophenolate mofetil could be interacting with the MMR proteins.…”

Section: Discussioncontrasting

confidence: 72%

See 1 more Smart Citation

Sebaceous carcinoma in solid organ transplant recipients

2017

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 72%

Sebaceous carcinoma in solid organ transplant recipients

2017

View full text Add to dashboard Cite

show abstract

“…Recently, staining for the androgen receptor was reported to be useful in diagnosing SC (39). Further studies using immunohistochemistry are warranted in Korea.…”

Section: Discussionmentioning

confidence: 99%

“…A surgical margin of 5–6-mm in WLE is commonly recommended for SCs, and a 2-mm margin in MMS has been reported to be effective (40). Although more studies comparing the long-term outcomes of MMS vs. WLE are necessary, MMS is recognized as the best initial treatment modality for SC (39). Both WLE and initial MMS in our study showed excellent results.…”

Section: Discussionmentioning

confidence: 99%

Sebaceous Carcinoma: Clinicopathologic Analysis of 29 Cases in a Tertiary Hospital in Korea

Park

Kim

et al. 2017

J Korean Med Sci

View full text Add to dashboard Cite

Sebaceous carcinoma (SC) is a neoplasm derived from the adnexal epithelium of the sebaceous glands, and most studies on this neoplasm have been conducted in Caucasians. We retrospectively reviewed the records of 29 patients with SC (16 extraocular and 13 ocular lesions) who were diagnosed from 2001 to 2014 to analyze the clinical and histopathological features of SC in the Korean population. Sixteen of the patients were women and 13 were men. There was an equal sex distribution for extraocular lesions, and a female predilection (M:F = 1:1.6) for ocular lesions. The mean ages at presentation of extraocular and ocular lesions were 69.19 ± 37.19 (range, 32–87) and 67.46 ± 24.46 (range, 43–85) years, respectively. Most lesions occurred in the eyelid (13/29, 44.83%), and most extraocular lesions occurred in the head and neck area (13/16, 81.25%). There was no recurrence or death during the follow-up period. Most lesions were poorly differentiated (extraocular, 43.75%; ocular, 38.46%), had a lobular infiltrative growth pattern (extraocular, 68.75%; ocular, 76.92%), and were basaloid (extraocular, 56.25%; ocular, 61.54%). Only 5 cases (2 extraocular and 3 ocular lesions) showed pagetoid spread. Extraocular lesions were marginally more common than the ocular form. There were higher incidences in elderly patients, who also had the highest incidence of eyelid lesions. The proportion of cells with sebaceous differentiation and prominent growth patterns were variable. Our results show that SC may not be very aggressive in Koreans.

show abstract

“…Leaving no residual cancer cells at the cutting edge is the key to success. Moreover, the recurrence is positively correlated with the tumor size, so an early diagnosis is important for the prognosis of a sebaceous gland carcinoma [24,25] . Because there is limited research on the ocular type of sebaceous gland carcinoma, there is no specific diagnosis and treatment for a mature teratoma with a malignant transformation.…”

Section: Yun-xiao Zhou Et Al 24mentioning

confidence: 99%

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Zhou

Jin

et al. 2018

Clin Surg Res Commun

View full text Add to dashboard Cite

A mature ovarian teratoma is a common benign germ cell tumor of the ovary in women that rarely causes a malignant transformation. However, a malignant transformation can occur in the ectodermal, mesodermal, and endodermal tissues of the tumor. A squamous cell carcinoma is the most common and an adenocarcinoma is the second most common malignant tumor derived from a cystic teratoma. Due to the rarity of malignant transformations in mature teratomas and the lack of clinical data, the clinical pathological features, malignant transformation mechanism, therapeutic methods, and prognosis-relevant factors are unclear. Currently, there is no specific diagnostic method, and it is a difficult lesion to diagnose before performing surgery. In order to improve clinicians' understanding of a malignant-transformed mature teratoma and identification of malignant-transformed teratomas at early stages, we have reported a case of a mature teratoma with the malignant transformation of a sebaceous gland carcinoma in the Yiwu Central Hospital in Zhejiang, China on May 31, 2018. A review of the literature is also presented to summarize the clinical symptoms, pathogenesis, diagnosis, and treatment of malignant-transformed mature teratomas.

show abstract

Characteristics of Sebaceous Carcinoma and Early Outcomes of Treatment Using Mohs Micrographic Surgery Versus Wide Local Excision: An Update of the Mayo Clinic Experience Over the Past 2 Decades

Abstract: MMS and WLE are effective treatments for SC. Further research is warranted to determine whether one treatment is more efficacious than the other.

Cited by 36 publications

References 27 publications

Sebaceous carcinoma in solid organ transplant recipients

Sebaceous carcinoma in solid organ transplant recipients

Sebaceous Carcinoma: Clinicopathologic Analysis of 29 Cases in a Tertiary Hospital in Korea

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Contact Info

Product

Resources

About