Sebaceous carcinoma in solid organ transplant recipients

Hoss, Elika; Nelson, Sara; Sharma, Amit

doi:10.1111/ijd.13490

Cited by 14 publications

(18 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings suggest that the development of OA sebaceous carcinoma relies exquisitely on the abrogation of TP53 and/or RB function-either mutational or viral protein-mediated. Furthermore, our results at least partially explain the previously reported predisposition for OA sebaceous carcinoma among patients with long-standing immunosuppression, including immunosuppression due to solid organ transplant (15)(16)(17) and HIV infection or AIDS (18).…”

Section: Discussionsupporting

confidence: 78%

“…One important risk factor for OA sebaceous carcinoma is longstanding immunosuppression, including that related to solid organ transplant (15)(16)(17) and HIV infection or AIDS (18). These associations not only emphasize the importance of a competent immune system in the pathogenesis of OA sebaceous carcinoma, but also suggest a potential etiologic relationship to an infectious agent.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations

Tetzlaff

Curry

Ning

et al. 2019

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose: Ocular adnexal (OA) sebaceous carcinoma is an aggressive malignancy of the eyelid and ocular adnexa that frequently recurs and metastasizes, and effective therapies beyond surgical excision are lacking. There remains a critical need to define the molecular-genetic drivers of the disease to understand carcinomagenesis and progression and to devise novel treatment strategies. Experimental Design: We present next-generation sequencing of a targeted panel of cancer-associated genes in 42 and whole transcriptome RNA sequencing from eight OA sebaceous carcinomas from 29 patients. Results: We delineate two potentially distinct moleculargenetic subtypes of OA sebaceous carcinoma. The first is defined by somatic mutations impacting TP53 and/or RB1 [20/29 (70%) patients, including 10 patients whose primary tumors contained coexisting TP53 and RB1 mutations] with frequent concomitant mutations affecting NOTCH genes. These tumors arise in older patients and show frequent local recurrence. The second subtype [9/29 (31%) patients] lacks mutations affecting TP53, RB1, or NOTCH family members, but in 44% (4/9) of these tumors, RNA sequencing and in situ hybridization studies confirm transcriptionally active high-risk human papillomavirus. These tumors arise in younger patients and have not shown local recurrence. Conclusions: Together, our findings establish a potential molecular-genetic framework by which to understand the development and progression of OA sebaceous carcinoma and provide key molecular-genetic insights to direct the design of novel therapeutic interventions.

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations

Tetzlaff

Curry

Ning

et al. 2019

Clinical Cancer Research

View full text Add to dashboard Cite

show abstract

“…4 The treatment of SC requires extensive surgical excision with lymph node dissection, whether or not associated with adjuvant radiotherapy or chemotherapy. 2,7 Our patient had no lymphovascular invasion and no metastasis; therefore, no other treatment besides excision was included. The prognosis depends above all on the early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Extraocular sebaceous carcinoma in a renal transplant patient: A case report

Frioui

Rabhi

Gargouri

et al. 2022

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…However, SEER registry data did not demonstrate an increased incidence of among a large cohort with chronic lymphatic leukaemia ( n = 28 964) or non‐Hodgkin lymphoma ( n = 94 967) . There may be an increased risk of sebaceous carcinoma in solid organ transplant recipients …”

Section: Clinical Featuresmentioning

confidence: 97%

Cutaneous sebaceous carcinoma

Rajak

Huilgol

et al. 2020

Aust J Dermatology

View full text Add to dashboard Cite

Cutaneous sebaceous carcinoma occurs almost exclusively on the head and neck and has a significant propensity for recurrence and metastasis. It is easily mistaken for benign conditions, resulting in inappropriate management. Thus, it is important to maintain a high index of suspicion. Despite previous reports, sebaceous carcinoma may occur with similar frequency in Asians and whites. Recent genetic data suggest there are multiple mutational groups of sebaceous carcinoma, paving the way for targeted treatment. After a diagnosis, investigations for staging and for Muir-Torre syndrome should be considered. The available evidence on the treatment options for sebaceous carcinoma is discussed, and specific recommendations for management are made.

show abstract

Sebaceous carcinoma in solid organ transplant recipients

Cited by 14 publications

References 16 publications

Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations

Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations

Extraocular sebaceous carcinoma in a renal transplant patient: A case report

Cutaneous sebaceous carcinoma

Contact Info

Product

Resources

About