Extraocular sebaceous carcinoma in a renal transplant patient: A case report

Abstract

The high risk of skin cancer after organ transplantation is a major clinical challenge. We describe a case of a patient presenting with sebaceous carcinoma (SC) after a kidney transplant. Although it is exceedingly rare, SC should always be considered in the presence of any skin lesion occurring after a transplant.

Patients with a new-onset cutaneous sebaceous neoplasm following immunosuppression should be evaluated for Muir-Torre syndrome with germline mismatch repair gene mutation analysis: case reports

“…Muir-Torre syndrome-associated sebaceous neoplasms in solid organ transplant recipients without Muir-Torre syndrome-type internal malignacies-case reports and retrospective study Twenty immunosuppressed renal transplant recipients without Muir-Torre syndrome have been observed who developed Muir-Torre syndromeassociated sebaceous neoplasms (Table 1), Dermatology Online Journal || Case Report [13,14,23,25,28,29,31,38,55,56]. In addition, three cardiac transplant recipients who developed Muir-Torre syndrome-associated sebaceous neoplasms but did not have Muir-Torre syndrome have been reported (Table 2), [16,26,28,38,55].…”

“…The renal transplant patients without Muir-Torre syndrome internal malignancies but with Muir-Torre syndrome-associated sebaceous neoplasms included three women (ranging in age from 48 years to 82 years, median 62 years), when their sebaceous neoplasm occurred and 18 men (ranging in age from 50 years to 87 years, median 66 years) when their sebaceous neoplasm occurred (Table 1), [13,14,23,25,28,29,31,38,55,56]. They either had one type (19 patients) or three types (1 patient) of sebaceous neoplasms.…”

Extraocular form of sebaceous carcinoma with an aggressive course

“…Extraocular localization is rare and of undetermined origin [3]. Cancer is more common among women between 60 and 80 years of age, as well as people exposed to chronic sun exposure and subjected to long-term immunosuppression [4][5][6]. It most often affects Asians.…”

“…Lokalizacja pozaoczna jest rzadka i ma nieokreślone pochodzenie [3]. Nowotwór występuje częściej u kobiet w wieku między 60. i 80. rokiem życia, a także osób narażonych na przewlekłą ekspozycję słoneczną oraz poddanych długotrwałej immunosupresji [4][5][6]. Najczęściej dotyczy Azjatów.…”