Characteristics of primary cutaneous metastasis in Department of Dermatology and Venereology, Dr. Hasan Sadikin General Hospital Bandung, Indonesia, in ten years

Abstract

Background: Cutaneous metastasis (CM) is a rare condition characterized by skin infiltration and cell proliferation from malignant tumor. Breast cancer is the most common primary malignancy causing CM. This retrospective study aimed to recognize the characteristics of CM from internal organ malignancies, based on the medical records from the Tumor and Dermatology Surgery Division, Department of Dermatology and Venereology, Dr. Hasan Sadikin General Hospital Bandung, Indonesia during October 2008-September 2018.
 Methods: The diagnosis of CM referred to clinical manifestations, histopathological, and immunohistochemical examinations. All medical records of patients contained gender and age, primary malignancy, clinical manifestations and location of skin disorders, time interval between diagnosis of primary malignancy and occurrence of CM, and mortality. Data were collected and evaluated descriptively.
 Results: A total of five subjects consisted of 3 patients with breast cancer, 1 patient with lung cancer, and 1 patient with prostate cancer. The subjects' age ranged from 40 to 49 years old (40%) and above 60 years old (40%) with the male to female ratio of 2:3. Breast cancer is found to be the most common malignancy (60%). All of the subjects had a skin lesion on the chest wall, abdomen, and back, and 60% of subjects had a nodule as a clinical manifestation. As much as 60% of subjects have died within four months after CM diagnosis was established. 
 Conclusion: Breast cancer is the most common cause of CM. The CM's primary malignancies are affected by sex, age, clinical manifestations, predilection, and mortality characteristics.

Incidence Rate and Clinical Characteristics of Triple Negative Breast Cancer Patients in Hasan Sadikin Hospital, for the Last Five Years

“…The incidence rate of TNBC is about 10-15% of all breast cancers. Due to poor progressivity and prognosis, it is important to understand more about this TNBC, so we provide an overview of the characteristics of TNBC patients in RSHS in the hope of adequately representing West Java because RSHS is a referral center throughout West Java (Sutedja et al, 2021).…”