Characteristics of pelvic inflammatory disease caused by sexually transmitted disease – An epidemiologic study

Yagur, Yael; Weitzner, Omer; Tiosano, Lisa Barchilon; Paitan, Yossi; Katzir, Michal; Schonman, Ron; Klein, Zvi; Miller, Netanella

doi:10.1016/j.jogoh.2021.102176

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…Symptomatic infection is observed in approximately 50% of women that can experience vaginitis and urethritis ( Sutton et al, 2007 ). In addition, trichomoniasis is associated with adverse outcomes during pregnancy and may contribute to pelvic inflammatory disease ( Silver et al, 2014 ; Yagur et al, 2021 ). In men, T. vaginalis infection is in over 75% of cases asymptomatic with parasites hidden in the prostate that represent a reservoir for transmission ( Hirt and Sherrard, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Double-Stranded RNA Viruses Are Released From Trichomonas vaginalis Inside Small Extracellular Vesicles and Modulate the Exosomal Cargo

et al. 2022

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Trichomonas vaginalis is a parasitic protist that infects the human urogenital tract. During the infection, trichomonads adhere to the host mucosa, acquire nutrients from the vaginal/prostate environment, and release small extracellular vesicles (sEVs) that contribute to the trichomonad adherence and modulate the host-parasite communication. Approximately 40–70% of T. vaginalis strains harbor a double-stranded RNA virus called Trichomonasvirus (TVV). Naked TVV particles have the potential to stimulate a proinflammatory response in human cells, however, the mode of TVV release from trichomonads to the environment is not clear. In this report, we showed for the first time that TVV particles are released from T. vaginalis cells within sEVs. The sEVs loaded with TVV stimulated a higher proinflammatory response of human HaCaT cells in comparison to sEVs from TVV negative parasites. Moreover, a comparison of T. vaginalis isogenic TVV plus and TVV minus clones revealed a significant impact of TVV infection on the sEV proteome and RNA cargo. Small EVs from TVV positive trichomonads contained 12 enriched and 8 unique proteins including membrane-associated BspA adhesine, and about a 2.5-fold increase in the content of small regulatory tsRNA. As T. vaginalis isolates are frequently infected with TVV, the release of TVV via sEVs to the environment represents an important factor with the potential to enhance inflammation-related pathogenesis during trichomoniasis.

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Section: Introductionmentioning

confidence: 99%

Double-Stranded RNA Viruses Are Released From Trichomonas vaginalis Inside Small Extracellular Vesicles and Modulate the Exosomal Cargo

et al. 2022

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“…Por outro lado, Yagur et al (2021), em seu estudo de coorte retrospectivo, conduzido entre 2016 e 2019 com 610 mulheres, mostrou que a maior incidência de infecção bacteriana em mulheres com DIP foi de Urea parvum (39,4%). No entanto, outros patógenos relacionados à dor pélvica foram a Chlamydia trachomatis (9,8%), Trichomonas vaginalis (3,4%), Mycoplasma genitalium (2,1%) e Neisseria gonorrhoeae (1,5%).…”

Section: Mulheresunclassified

Associação entre Mycoplasma genitalium e doença inflamatória pélvica: revisão sistemática

Silva

Bitar²,

Trombetta³

et al. 2023

RSD

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O Mycoplasma genitalium tem se configurado como uma das infecções sexualmente transmissíveis mais emergentes de todo o mundo. Quando instalado, pode estar associado a complicações como as cervicites, uretrite não gonocócica e a endometrite. Também há evidência do surgimento da doença inflamatória pélvica nas pacientes com Mycoplasma genitalium, ainda que haja escassez de dados sobre isso. Portanto, buscou-se avaliar a existência de associação entre Mycoplasma genitalium e a doença inflamatória pélvica ou dor pélvica. Para tanto, realizou-se uma revisão sistemática em janeiro de 2023, considerando estudos de coorte, ensaios clínicos e estudos transversais. Utilizou-se as bases PubMed e CINAHL, bem como, as bibliotecas virtuais BVS e Google Scholar. Também, buscou-se na plataforma AskMEDLINE, usando-se a pergunta norteadora. Os estudos estiveram limitados aos idiomas português, inglês e espanhol, e publicados entre 2012 e 2022. Dos 2.413 trabalhos encontrados, apenas cinco foram selecionados para a amostra final. Todos os achados mostraram associação entre o Mycoplasma genitalium e a doença inflamatória pélvica, embora essa relação fosse bastante variável (2,1%-38%). A dor pélvica também esteve presente nas pacientes testadas, ainda que um quadro assintomático ou oligossintomático também tenha sido relatado em grande de parte dos casos. Apesar do Mycoplasma genitalium representar uma importante parcela das infecções que geram a doença pélvica, a Chlamydia trachomatis ainda é a principal responsável por isso. Contudo, novas investigações precisam ser desenhadas na tentativa de elucidar relações da infecção com outras infecções sexualmente transmissíveis e manifestações clínicas comuns.

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“…The overgrowth of pathogenic microbiomes disturbs the vaginal and cervical defence mechanisms and they ascend towards the upper FRT, resulting in dysbiosis and infection [ 111 ]. If left untreated, PID may be associated with chronic pelvic pain, ectopic pregnancy, infertility, endometriosis, and ovarian cancer [ 111 , 112 , 113 ].…”

Section: Vaginal Drug Delivery Systems: History and Present Therapeuticsmentioning

confidence: 99%

Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery

Thapa

Gurung

Parat

et al. 2022

Gels

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Approaches for effective and sustained drug delivery to the female reproductive tract (FRT) for treating a range of gynaecological conditions remain limited. The development of versatile delivery platforms, such as soluble gels (sol–gels) coupled with applicators/devices, holds considerable therapeutic potential for gynaecological conditions. Sol–gel systems, which undergo solution-to-gel transition, triggered by physiological conditions such as changes in temperature, pH, or ion composition, offer advantages of both solution- and gel-based drug formulations. Furthermore, they have potential to be used as a suitable drug delivery vehicle for other novel drug formulations, including micro- and nano-particulate systems, enabling the delivery of drug molecules of diverse physicochemical character. We provide an anatomical and physiological perspective of the significant challenges and opportunities in attaining optimal drug delivery to the upper and lower FRT. Discussion then focuses on attributes of sol–gels that can vastly improve the treatment of gynaecological conditions. The review concludes by showcasing recent advances in vaginal formulation design, and proposes novel formulation strategies enabling the infusion of a wide range of therapeutics into sol–gels, paving the way for patient-friendly treatment regimens for acute and chronic FRT-related conditions such as bacterial/viral infection control (e.g., STDs), contraception, hormone replacement therapy (HRT), infertility, and cancer.

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Characteristics of pelvic inflammatory disease caused by sexually transmitted disease – An epidemiologic study

Cited by 12 publications

References 20 publications

Double-Stranded RNA Viruses Are Released From Trichomonas vaginalis Inside Small Extracellular Vesicles and Modulate the Exosomal Cargo

Double-Stranded RNA Viruses Are Released From Trichomonas vaginalis Inside Small Extracellular Vesicles and Modulate the Exosomal Cargo

Associação entre Mycoplasma genitalium e doença inflamatória pélvica: revisão sistemática

Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery

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