Characteristics of Patients with Type 2 Diabetes Mellitus in Al-Ihsan Regional General Hospital

Trusda, Siti Annisa Devi; Purbaningsih, Wida; Budiman, Budiman; Fitriadi, Siti Salma Nurhaliza

doi:10.29313/gmhc.v9i2.8123

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…PPARα activation affects lipoprotein metabolism and reduces dyslipidemia associated with metabolic syndrome and hypertension. 17 PPARα activation also causes inhibition of expression of nuclear factor κB (NF-κB) or inflammatory protein activator 1. 18,19 Fibrate a PPARα agonist and have been used to treat dyslipidemia, studies have also proven PPARα agonists have antiinflammatory that suppresses pro-inflammatory cytokines interleukin-1 beta, TNFα, ICAM-1 and anti-thrombotic effects.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet

Jasaputra,

Yumilia,

Gunadi

et al. 2023

Glob Med Health Commun

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High levels of fat in the blood are a risk factor for nonalcoholic steatohepatitis liver disease. Indonesian medicinal plants that can decrease blood fat levels are turmeric and mangosteen peel. One of the mechanisms of blood fat-lowering drugs is to increase the expression of the PPARα gene. The purpose of this study was to assess the effect of turmeric and mangosteen peel on the expression of the PPARα gene in the rat liver induced by a high-fat diet. This research was conducted at Maranatha Biomedical Research Laboratory in February–October 2021, using male Wistar rats that were divided into 5 groups (n=5): negative control groups (no treatment), positive control groups (high-fat diet), turmeric, mangosteen, and fenofibrate groups, that was given high-fat diet continued by ethanol extract of turmeric, ethanol extract of mangosteen peel, and fenofibrate. At the end of the study, the animals were terminated, and the liver was extracted for RNA extraction and semi-quantitative PCR. The results showed that there was an increase in PPARα gene expression in the turmeric group and fenofibrate group, which were significantly different from the positive control group that received a high-fat diet (p<0.05) and between the fenofibrate group compared to negative controls that received standard chow diet (p<0.05). In conclusion, turmeric and fenofibrate are suggested to increase the expression of the PPARα gene in the liver induced by a high-fat diet.

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Section: Discussionmentioning

confidence: 99%

The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet

Jasaputra,

Yumilia,

Gunadi

et al. 2023

Glob Med Health Commun

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“…Pada penelitian lain yang membahas mengenai usia lebih dari 50 tahun sebagai salah satu faktor risiko terjadinya DM menyebutkan bahwa fungsi fisiologis pada tubuh akan mengalami penuruan akibat proses penuaan sehingga dapat menimbulkan beberapa penyakit berupa Penyakit Tidak Menular (PTM) contohnya adalah DM dan hipertensi. [22], [23] Alasan lain yang menguatkan hasil penelitian ini adalah lebih sering terjadi DM tipe 2 pada perempuan dikarenakan perempuan memiliki body mass index (BMI) yang lebih besar dibandingkan dengan laki laki, serta pasca menopause yang mengakibatkan adanya distribusi lemak dalam tubuh yang lebih mudah terakumulasi akibat adanya proses hormonal pada perempuan. Perempuan dengan BMI lebih besar dari 24 memiliki risiko tinggi terkena DM tipe 2, terlepas dari usia saat terjadinya menopause, perempuan yang terlambat menopause memiliki risiko tinggi terkena DM tipe 2.…”

Section: J U M L a H P A S I E N P E R T A H U Nunclassified

Gambaran Karakteristik Pasien Diabetes Melitus tipe 2 dengan Hipertensi di RSUD Al Ihsan Bandung

Amani¹,

Trusda²,

Surialaga³

2023

BCSMS

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Abstract Type 2 diabetes mellitus is a set of metabolic symptoms characterized by hyperglycemia, occurring due to insulin resistance, insulin malfunction, or both.. DM type 2 is a disease that has had a high increase in prevalence, over the past 15 years in Bandung. Hypertension is the most common condition accompanying DM Type 2. The purpose of this study was to determine the characteristic picture of type 2 DM patients with hypertension in Al-Ihsan Regional General Hospital Bandung for the 2019-2021 period. This research is an observational descriptive study conducted with a cross-sectional design. The subjects in this study were dm type 2 patients with hypertension at Al-Ihsan Regional General Hospital Bandung for the 2019-2021 period, totaling 2057 people selected with total sampling, using secondary data from medical record. The results of this study showed that in type 2 DM patients with hypertension at Al-Ihsan Hospital Bandung more occurred at the age of 55-64 years with a total of 815 (39.62%), there were 1383 female patients (67.23%), and the majority of patients residing in Bandung Regency, namely 1983 (96.40%). Abstrak Diabetes melitus (DM) tipe 2 adalah sekumpulan gejala metabolik yang ditandai dengan hiperglikemia, terjadi karena resistensi insulin, kegagalan fungsi insulin, atau keduanya. DM tipe 2 mengalami peningkatan prevalensi tinggi selama 15 tahun terakhir di Bandung. Hipertensi merupakan keadaan yang paling sering menyertai DM Tipe 2. Tujuan penelitian ini adalah untuk mengetahui gambaran karakteristik pasien DM tipe 2 dengan hipertensi di Rumah Sakit Al-Ihsan Bandung periode tahun 2019-2021. Penelitian ini merupakan penelitian deskriptif observasional yang dilakukan dengan rancangan potong lintang. Subjek dalam penelitian ini merupakan pasien DM tipe 2 dengan hipertensi di RSUD Al-Ihsan Bandung periode 2019-2021 yang berjumlah 2057 orang dipilih dengan total sampling dengan menggunakan data sekunder dari rekam medis. Hasil penelitian ini menunjukkan bahwa pada pasien DM tipe 2 dengan hipertensi di RSUD Al-Ihsan Bandung lebih banyak terjadi pada usia 55-64 tahun dengan jumlah 815 (39,62%), pasien perempuan lebih banyak dibandingkan pasien laki-laki yang berjumlah 1383 (67,23%), serta mayoritas pasien bertempat tinggal di Kabupaten Bandung yaitu sebanyak 1983 (96,40%).

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Characteristics of Patients with Type 2 Diabetes Mellitus in Al-Ihsan Regional General Hospital

Cited by 2 publications

References 38 publications

The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet

The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet

Gambaran Karakteristik Pasien Diabetes Melitus tipe 2 dengan Hipertensi di RSUD Al Ihsan Bandung

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