Characteristics of Nasal Inverted Papilloma and Its Malignant Transformation: A Study of Cell Proliferation and Programmed Cell Death

Fan, Guo-Kang; Imanaka, Masashi; Yang, Baoyu; Takenaka, Hiroshi

doi:10.2500/ajr.2006.20.2851

Cited by 32 publications

(28 citation statements)

References 21 publications

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“…Our study did not reveal statistically significant differences of Bcl-2 immunoexpression between sinonasal IPs and control group. Surprising results were provided by Fan et al [40] who found no differences regarding immunoexpression of Bcl-2 among SNC, sinonasal IP and sinonasal IP with dysplasia. In our study the high, nuclear survivin immunoexpression in SNC and sinonasal IP tissues was correlated with high immunoexpression of Bcl-2 oncoprotein.…”

Section: Discussionmentioning

confidence: 80%

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2013

Folia Histochem Cytobiol.

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Abstract:The immunoexpression of the inhibitor of apoptosis protein survivin has been shown to be a significant prognostic factor in various human cancers. Immunohistochemical method was used to examine the expression of survivin, Ki67 and Bcl-2 in 20 cases of sinonasal inverted papillomas (IPs), 12 cases of sinonasal squamous cell carcinoma (SNCs) and 19 cases of nasal chronic sinusitis as a control. Nuclear immunostaining for survivin was observed in 14 of 20 (70%) cases of sinonasal IPs and 10 of 12 (83.4%) cases of SNCs. Apart from nuclear, also weak cytoplasmic immunoexpression of survivin was detected in 2 of 20 cases (10%) of sinonasal IP and moderate intense staining in 9 of 12 cases (75%) of SNC. There was no immunostaining for survivin in 19 control cases. The immunoexpression of survivin, Ki67 and Bcl-2 was significantly higher in SNCs than in sinonasal IPs and control group. Moreover, nuclear survivin and Ki67 antigen immunoexpression were significantly higher in sinonasal IPs group as compared to control group. There were statistically significant positive correlations between nuclear (but not cytoplasmic) immunoexpression of survivin and Ki67 antigen, as well as Bcl-2 oncoprotein in both tested tumors. In conclusion, our findings suggest that survivin, Ki67 and Bcl-2 may be involved in sinonasal tumorigenesis.

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Section: Discussionmentioning

confidence: 80%

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2013

Folia Histochem Cytobiol.

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“…Fan et al [12] proposed programmed cell death theory in the causation of malignant transformation and they concluded that inhibition of apoptosis could be an early sign of inverted papilloma undergoing malignant transformation. A high proliferative rate was a characteristic of inverted papilloma-associated malignant diseases [16]. A group of Chinese investigator investigated the role of fascin which may play a role in the formation of inverted papilloma.…”

Section: Discussionmentioning

confidence: 99%

Inverted Papilloma: A Clinico-Pathological Dilemma with Special Reference to Recurrence and Malignant Transformation

Ghosh

Sen

Chandra

et al. 2010

Indian J Otolaryngol Head Neck Surg

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To study the clinicopathological profile, recurrence and malignant potential of the inverted papilloma of nose and paranasal sinuses in relation to the definitive diagnosis and the management undertaken. A total number of 52 cases of histologically proven inverted papilloma managed in our department of otolaryngology over a 10-year period (May 1998-April 2008) were followed up (until October 2009) and the results were analyzed retrospectively to find out any incidence of recurrence of these tumours. A total of 52 inverted papilloma cases were managed with different surgical interventions. Male:female ratio was found to be 10:1. The mean follow up period was 74 months (range 16 months-11 years). Recurrence was observed in 20 (38%) cases. 23% had recurrence without any specific histological pattern, 12% had recurrence with focal dysplasia and 4% had recurrence with malignant transformation into squamous cell carcinoma (SCC). Post-operative radiotherapy was given to 8% (four cases) with malignant transformation. The management of inverted papilloma depends on its size and extension. Recurrence can be minimized by an appropriate surgical planning. Careful endoscopic assessment is essential to detect early recurrence. Recurrent inverted papilloma should be treated more aggressively. Malignant transformation in inverted papilloma should be managed like any aggressive sino-nasal malignancy.

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“…IP contains a significantly higher cell population with proliferative activity by comparison with normal sinonasal and inflammatory polyp epithelia, showing a significant correlation between Topoisomerase II-alpha (topoII-alpha) and Ki67 expression, and indicating that topoII-alpha could be a independent prognostic factor for a putative malignant transformation [176, 177]. Immunohistochemical staining of inverted sinonasal papillomas for p53 [115, 175, 178–187] and Ki67 can give useful information concerning the existence of synchronous carcinoma [173, 188] and, in case of high Ki67, a hint toward possible recurrence [136, 177, 189, 190, 190–193]. A study demonstrated ectopic production of beta-human chorionic gonadotropin in cases of inverted papilloma of the nose [194].…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Skull Base Inverted Papilloma: A Comprehensive Review

2012

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Skull base inverted papilloma (IP) is an unusual entity for many neurosurgeons. IP is renowned for its high rate of recurrence, its ability to cause local destruction, and its association with malignancy. This paper is a comprehensive review of the reports, studies, and reviews published in the current biomedical literature from 1947 to September 2010 and synthesize this information to focus on its potential invasion to the base of the skull and possible intradural extension. The objective is to familiarize the clinician with the different aspects of this unusual disease. The role of modern diagnostic tools in medical imaging in order to assess clearly the limits of the tumors and to enhance the efficiency and the safety in the choice of a surgical approach is pointed out. The treatment guidelines for IP have undergone a complex evolution that continues today. Radical excision of the tumour is technically difficult and often incomplete. Successful management of IP requires resection of the affected mucosa which could be achieved with open surgery, endoscopic, or combined approach. Radio and chemotherapy were used for certain indications. More optimally research would be a multicenter randomized trials with large size cohorts.

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Characteristics of Nasal Inverted Papilloma and Its Malignant Transformation: A Study of Cell Proliferation and Programmed Cell Death

Abstract: We concluded that inhibition of apoptosis could be an early sign of IP undergoing malignant transformation. A high proliferative rate was a characteristic of IP-associated malignant diseases.

Cited by 32 publications

References 21 publications

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Inverted Papilloma: A Clinico-Pathological Dilemma with Special Reference to Recurrence and Malignant Transformation

Skull Base Inverted Papilloma: A Comprehensive Review

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