Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Stasikowska-Kanicka, Olga; Wągrowska-Danilewicz, Małgorzata; Danilewicz, Marian

doi:10.5603/fhc.2013.0032

Cited by 7 publications

(11 citation statements)

References 37 publications

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“…This hypothesis is consistent with the downregulation of Ki-67 in the current study, considering the previous evidence (Stasikowska-Kanicka, Wagrowska-Danilewicz, & Danilewicz, 2013;Tan et al, 2005).…”

Section: Discussionsupporting

confidence: 94%

Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti‐inflammatory, and immunostimulatory activities in 4T1 tumor‐bearing Balb/c mice

Rashidi

Khalilnezhad

Amani

et al. 2018

Journal Cellular Physiology

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Umbelliprenin (UMB) has shown various pharmacological properties in vitro. We investigated the antineoplastic and immunostimulatory effects of UMB in 4T1 mammary-tumor-bearing mice. Two-hundred microliter of UMB (12.5 mg/ml) was intraperitoneally administrated to healthy and tumor-bearing female Balb/c mice for a period of 18 days. Data was analyzed using GraphPad Prism 5 software for Windows (version 5, La Jolla, CA). UMB caused a significant decrease in tumor size (P < 0.01). Serum interferon gamma (IFNγ) was augmented in both healthy and tumor-bearing animals (P < 0.01), and IL-4 declined in healthy animals (P < 0.01) treated with UMB. Expressions of Ki-67, VEGF, CD31, MMP2, MMP9, VCAM1, and NF-κB were significantly decreased in tumors from UMB-treated animals (P < 0.001), whereas E-Cadherin and TNFR1 expressions were markedly increased (P < 0.001). The rates of liver and lung metastases in UMB-administrated animals were smaller compared to the control. UMB can potently inhibit tumor growth, angiogenesis, metastasis, and inflammation and potentiate an antitumor immune response in vivo. However, further investigations are required to evaluate the UMB mechanisms of action in cancerous cells.

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Section: Discussionsupporting

confidence: 94%

Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti‐inflammatory, and immunostimulatory activities in 4T1 tumor‐bearing Balb/c mice

Rashidi

Khalilnezhad

Amani

et al. 2018

Journal Cellular Physiology

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“…It is interesting to note that nuclear immunoexpression of Survivin was detected in some areas of the epithelium (Fig. 2f), which according to Stasikowska-Kanicka et al (32), fosters cell proliferation, while its cytoplasmic immunoexpression is involved in the mechanisms of apoptosis regulation. On the other hand, both Bcl-2 and Bax participate as transcriptional targets for p53, a tumor suppressor protein, which brings about cell cycle arrest or apoptosis in response to DNA damage.…”

Section: Discussionmentioning

confidence: 72%

Primordial odontogenic tumor: An immunohistochemical profile

Bologna‐Molina

Mikami²,

Pereira-Prado³

et al. 2017

Med Oral

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BackgroundPrimordial Odontogenic Tumor (POT) is a recently described odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla, covered by cuboidal to columnar epithelium that resembles the internal epithelium of the enamel organ, surrounded at least partly by a delicate fibrous capsule. The purpose of this study was to investigate the possible histogenesis and biological behavior of this rare tumor by means of a wide immunohistochemical analysis of its epithelial and mesenchymal components.Material and MethodsThe immunoexpression of twenty-three different antibodies were evaluated in four cases of POT.ResultsThe epithelial cells that cover the periphery of the tumor showed immunopositivity for Cytokeratins 14 and 19, while Amelogenin, Glut-1, MOC-31, Caveolin-1. Galectin-3, PITX2, p53, Bax, Bcl-2, Survivin and PTEN were variably expressed in focal areas. The mesenchymal component of the tumor was positive for Vimentin, Syndecan-1, PITX2, Endoglin (CD105), CD 34, Cyclin D1, Bax, Bcl-2, Survivin and p53. PTEN and CD 90 showed a moderate positivity. BRAF V600E and Calretinin were negative in all samples. Cell proliferation markers (Ki-67, MCM-7) were expressed in <5% of the tumor cells.ConclusionsAccording to these immunohistochemical findings, we may conclude that POT is a benign odontogenic tumor in which there is both epithelial and mesenchymal activity during its histogenesis, as there is expression of certain components in particular zones in both tissues that suggests this tumor develops during the immature (primordial) stage of tooth development, leading to its inclusion within the group of benign mixed epithelial and mesenchymal odontogenic tumours in the current World Health Organization classification of these lesions. Key words:Immunohistochemistry, jaw tumors, odontogenic, primordial.

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“…Tsou et al [36] in a recent study on a cohort of 70 patients observed significantly elevated levels of Ki-67, p27, and PCNA in SNIPs with sinonasal SCC transformation compared with SNIPs without malignancy. Other authors have revealed that the nuclear immunoexpression of the inhibitor of apoptosis protein survivin and Bcl-2 oncoprotein immunoexpression are significantly higher in SNIP, suggesting that survivin and Bcl-2 may be involved in sinonasal tumorigenesis [37].…”

Section: Ki-67 Pcna Bcl-2mentioning

confidence: 99%

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

Gioacchini

Bajraktari

et al. 2017

Eur Arch Otorhinolaryngol

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Schneiderian papillomas are uncommon tumors which may develop within the nasal cavity and comprise three well-defined histological types: sinonasal inverted papilloma (SNIP), exophytic papilloma, and oncocytic papilloma. It is well known the rate of Schneiderian papilloma may also present a malignant degeneration and SNIP represents the most important subgroup in consideration of its frequency and malignant propensity. Although HPV infection is always considered the first event favoring the development of SNIP, however, it is not established as an eventual connection between viral actions and malignant transformation. In fact, different molecular mechanisms are suspected to play a crucial role in this process and, currently, many authors agree that only by improving our knowledge about these mechanisms it will be possible to achieve new and effective targeted therapies. So the aim of this study was firstly to systematically review the literature focusing on different biomarkers that could be implicated in the stages of SNIP malignant degeneration. Secondly, a systematic review with meta-analysis was performed to better define the incidence of sinonasal malignancies originating from Schneiderian papilloma (SNIP, exophytic papilloma, and oncocytic papilloma). Twenty-nine studies comprising a total of 3177 patients were statistically analyzed. Results showed a 9% (95% CI = 7-11) overall rate of malignant transformation from Schneiderian papilloma. In conclusion, this analysis confirmed that the potential malignancy of Schneiderian papilloma should not be underestimated. On the other hand, our review showed the paucity of studies investigating the molecular alterations which may be related with the malignant transformation of SNIP.

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Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Cited by 7 publications

References 37 publications

Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti‐inflammatory, and immunostimulatory activities in 4T1 tumor‐bearing Balb/c mice

Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti‐inflammatory, and immunostimulatory activities in 4T1 tumor‐bearing Balb/c mice

Primordial odontogenic tumor: An immunohistochemical profile

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

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