Characteristics and outcome of 102 fetuses with fetal cerebral ventriculomegaly: Experience of a university hospital in Turkey

Abstract

The aim of this study was to evaluate the incidence of associated structural anomalies and the outcome of fetuses with ventriculomegaly. We retrospectively collected 102 cases of antenatally diagnosed ventriculomegaly examined between 2000 and 2008. Ventricular width measurements were 10-12 mm, 12.1-14.9 mm and ≥ 15 mm in 24.5%, 20.6% and 54.9% of the cases, respectively. Associated structural malformations were detected in 77.4% of the fetuses. Mortality rate of fetuses with associated malformations and isolated ventriculomegaly was 86.1% and 55.7%, respectively (p < 0.001). The mortality rate was significantly lower in mild (10-12 mm) than in moderate (12.1-14.9 mm) and severe (≥ 15 mm) cases (p < 0.05). All of the fetuses with mild isolated ventriculomegaly were alive at >12 months of age, without morbidity. Our results suggest that the prognosis of fetuses with ventriculomegaly mainly depends on the aetiology and on the presence of associated abnormalities. Fetuses with mild isolated ventriculomegaly have a favourable outcome.

Fetal ventriculomegaly: Pregnancy outcomes and follow-ups in ten years

“…Corpus callosum anomalies were the most frequently found malformations in our study, as in the previous studies (9,17,(21)(22)(23)(24). In our study, 107 fetuses (70.9%) with "Mild Ventriculomegaly" and 30 (50.6%) with "Moderate Ventriculomegaly" had associated abnormalities.…”

Severe apparently isolated fetal ventriculomegaly and neurodevelopmental outcome

“…We observed better neurodevelopmental outcome for children with isolated SVM in our cohort compared with the literature . Prenatal assessment was complete for all patients with fetal ultrasound, fetal MRI during the third trimester, and amniocentesis to search for any chromosomal anomalies and perform infectious disease screening.…”

“…Generally, the outcome of children with SVM is considered to be poor, but only very few and small retrospective studies have been performed, with a follow‐up ranging between 4 and 48 months (Table ). Reported results are conflicting.…”

Chromosomal microarray analysis vs. karyotyping for fetal ventriculomegaly: a meta-analysis

“…Upon further review, 23 articles were included in the final analysis [Figure 1]. [4–26] Table 1 lists the number of cases and chromosomal abnormalities of the 17 included studies of conventional chromosome karyotype analysis. Table 2 describes the number of cases and the incremental yield of the eight included studies of CMA in VM.…”

“…Tomlinson 1997 [4] 25 3 25 (3) ---Vergani 1998 [5] 39 9 5 (2) 34 ( 7) --Greco 2001 [6] 14 1 14 (1) ---Gaglioti 2005 [7] 152 11 ----Breeze 2005 [8] 18 2 18 (2) ---Ouahba 2006 [9] 167 4 167 (4) ---Weichert 2010 [10] 60 5 ----Madazli 2011 [11] 67 2 ----Sethna 2011 [12] 154 39 ----Gezer 2014 [13] 140 7 24 (1) 72 (3) 11 ( 2) 33 (1) Chu 2016 [14] 57 5 ----Gezer 2016 [15] 27 0 ----Chang 2013 [16] 92 5 54 (3) 34 ( 2) 1 (0) 3 (0) Song 2010 [17] 132 25 58 (3) 60 ( 20) 1 (0) 13 (2) Hannon 2012 [18] 57 5 ----Li 2017 [19] 341 21 ----Donnelly 2014 [20] 93 12 ----…”