Severe apparently isolated fetal ventriculomegaly and neurodevelopmental outcome

Letouzey, Mathilde; Chadie, Alexandra; Brasseur‐Daudruy, M.; Proust, F.; Verspyck, É.; Boileau, Pascal; Marret, Stéphane

doi:10.1002/pd.5095

Cited by 18 publications

(18 citation statements)

References 21 publications

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“…Graham (2001) 25 Gaglioti (2005) 8 Breeze (2007) 17 Kennelly (2009) 16 Weichert (2010) 26 Gezer (2015) 27 Chu (2016) 15 Gezer (2016) 28 Bar-Yosef (2017) 31 Letouzey (2017) 16 1 0.100 (0.00-0.45) 4 0.400 (0.12-0.74) 5 0.500 (0.19-0.81) 9 0.900 (0.55-1.00) 10 Weichert (2010) 26 6 0.316 (0.13-0.57) 0 0.00 (0.00-0.18) 13 0.684 (0.43-0.87) 13 0.684 (0.43-0.87) 19 Gezer (2015) 27 3 0.750 (0.19-0.99) 0 0.00 (0.00-0.60) 1 0.250 (0.01-0.81) 1 0.250 (0.01-0.81) 4 Chu (2016) 15 5 0.625 (0.24-0.91) 0 0.00 (0.00-0.37) 3 0.375 (0.09-0.76) 3 0.375 (0.09-0.76) 8 Gezer (2016) 28 5 0.625 (0.24-0.91) 0 0.00 (0.00-0.37) 3 0.375 (0.09-0.76) 3 0.375 (0.09-0.76) 8 Bar-Yosef (2017) 31 1 1.00 (0.03-1.00) 0 0.00 (0.00-0.98) 0 0.00 (0.00-0.98) 0 0.00 (0.00-0.98) 1 Letouzey (2017) 30 Only first author's name given for each study.…”

Section: Synthesis Of Resultsmentioning

confidence: 99%

Outcome of fetuses with prenatal diagnosis of isolated severe bilateral ventriculomegaly: systematic review and meta‐analysis

Carta

Agten

Belcaro

et al. 2018

Ultrasound in Obstet & Gyne

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Four-fifths of fetuses with severe ventriculomegaly survive and, of these, just over two-fifths show normal neurodevelopment. The overall survivors without disability account for more than one third of the total. Given that many cases undergo termination of pregnancy and require longer follow-up in order to detect subtle abnormalities, mortality and prevalence of developmental delay may be even higher than that reported in this paper. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

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Section: Synthesis Of Resultsmentioning

confidence: 99%

Outcome of fetuses with prenatal diagnosis of isolated severe bilateral ventriculomegaly: systematic review and meta‐analysis

Carta

Agten

Belcaro

et al. 2018

Ultrasound in Obstet & Gyne

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“…While isolated VM can be compatible with normal neurodevelopment, hydrocephalus in association with other anomalies leads to a less favorable prognosis, and fetal MR can be additive in characterizing underlying parenchymal malformations . Gaglioti et al report that the neurodevelopmental outcome of isolated VM is most often normal when mild (ventricular width between 10 and 12 mm), while the rates of associated malformations, chromosomal anomalies, and infection are higher with moderate or severe VM, leading to less favorable outcomes . In our series, VM was severe enough to manifest as fetal macrocephaly.…”

Section: Discussionmentioning

confidence: 64%

“…while the rates of associated malformations, chromosomal anomalies, and infection are higher with moderate or severe VM, leading to less favorable outcomes. 2,3,[18][19][20] In our series, VM was severe enough to manifest as fetal macrocephaly. In conjunction with an underlying callosal anomaly and interhemispheric cyst, these prenatal AVID findings appear to increase the probability of developmental disabilities compared with isolated VM.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes following prenatal diagnosis of asymmetric ventriculomegaly, interhemispheric cyst, and callosal dysgenesis (AVID)

Gibson

Pinter³

et al. 2018

Prenatal Diagnosis

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What's already known about this topic? Fetal ventriculomegaly can be isolated or be a component of structural brain anomaly. Prenatal counseling can be challenging given the variable clinical outcomes associated with fetal ventriculomegaly. When fetal ventriculomegaly is associated with a structural anomaly such as a callosal malformation, postnatal outcomes are worse than for isolated ventriculomegaly. What does this study add? When severe asymmetric ventriculomegaly is identified, an underlying callosal anomaly and midline interhemispheric cyst can be present (AVID triad). Prenatal diagnosis of the AVID triad leads to progressive severe macrocephaly in utero, which often leads to cesarean section delivery. All children in our series with prenatally diagnosed AVID required at least one and in general several neurosurgical procedures, including CSF shunting in all cases. Most of these children had at least moderate to severe motor and language delays, with a wide range of visual deficits, craniofacial abnormalities, and medical comorbidities.

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“…8 Depending on the extent of ventriculomegaly and presence of other congenital anomalies, hydrocephalus is classified as mild, moderate, or severe. 8,9 Literature about the clinical outcome of congenital hydrocephalus according to its severity is sparse. 9,10 Considering all the above-mentioned facts, the present study was aimed to determine the incidence, risk factors, severity, and outcome of congenital hydrocephalus in our institute, which is a tertiary healthcare center located in northern India.…”

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confidence: 99%

Evaluation of the incidence, risk factors, severity, and outcome of hydrocephalic fetuses in a tertiary healthcare center located in Northern India: a prospective observational study

Garg

Najam

Agarwal

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Hydrocephalus is a heterogeneous disease marked by abnormal dilatation of the cerebral ventricles secondary to varying etiologies. This study was aimed to determine the incidence, risk factors, severity, and outcome of hydrocephalic fetuses presenting to a tertiary healthcare hospital located in northern India.Methods: In this prospective observational study, pregnant women visiting the obstetrics outpatient department of our hospital from 01 July 2017 to 31 June 2018 were screened for hydrocephalic fetuses via ultrasonography along with a detailed history, and a comprehensive battery of diagnostic investigations. They were followed up for a minimum period of two months after delivery/termination of pregnancy.Results: A total of 3627 pregnant women were screened, of which 10 had hydrocephalic fetuses in the observed time period. The incidence of hydrocephalus was determined to be 2.75 per 1000 live births. Low socio-economic status was identified as a major risk factor. 50% of the hydrocephalic fetuses were severely afflicted and were discontinued. The remaining 50% were successfully delivered and were managed via a ventriculo-peritoneal shunt or are under close observation in the postnatal period without any adverse outcome.Conclusions: The burden of hydrocephalus is considerably high in India, as compared to western countries. In rural settings, low socioeconomic status and lack of folic acid supplementation have a major influence in the etiopathogenesis of hydrocephalus. Management of hydrocephalus requires a multidisciplinary approach and is tailored according to the severity of the presentation. Severe cases of hydrocephalus and cases with associated anomalies have a poor prognosis.

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Severe apparently isolated fetal ventriculomegaly and neurodevelopmental outcome

Abstract: The majority of children with apparently isolated SVM show normal neurodevelopmental outcome. No prenatal risk factor identify cases at higher risk for severely abnormal neurologic outcome. © 2017 John Wiley & Sons, Ltd.

Cited by 18 publications

References 21 publications

Outcome of fetuses with prenatal diagnosis of isolated severe bilateral ventriculomegaly: systematic review and meta‐analysis

Outcome of fetuses with prenatal diagnosis of isolated severe bilateral ventriculomegaly: systematic review and meta‐analysis

Clinical outcomes following prenatal diagnosis of asymmetric ventriculomegaly, interhemispheric cyst, and callosal dysgenesis (AVID)

Evaluation of the incidence, risk factors, severity, and outcome of hydrocephalic fetuses in a tertiary healthcare center located in Northern India: a prospective observational study

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