Fetal ventriculomegaly: Pregnancy outcomes and follow-ups in ten years

Prognosis of fetuses with ventriculomegaly: An observational retrospective study

“…It has been reported that the risk of neurological abnormalities is 12% in mild VM, increasing to 75% in moderate to severe VM, and that fetuses with progressive lateral ventricular width dilatation are more prone to neurodevelopmental retardation. 25,26 In our study, 173 out of 234 patients had ongoing pregnancies, all of which had mild or moderate VM. There were significant differences in in utero outcomes between mild and moderate VM groups, as well as between IVM and NIVM subgroups.…”

Congenital aqueduct stenosis: Progressive brain findings in utero to birth in the presence of severe hydrocephalus

“…This ventriculomegaly typically occurs in the presence of obstruction to cerebrospinal flow at the level of the aqueduct of Slyvius, thus causing increase in intracranial pressure, which is labeled as hydrocephalus. Prior studies suggest that the chance of adverse neurodevelopmental outcome is highest in patients with severe lateral ventriculomegaly, defined as lateral ventricular diameter of greater than and/or equal to 15 mm in the atrial horn detected prenatally …”

“…Prior studies suggest that the chance of adverse neurodevelopmental outcome is highest in patients with severe lateral ventriculomegaly, defined as lateral ventricular diameter of greater than and/or equal to 15 mm in the atrial horn detected prenatally. [3][4][5] When cerebral spinal fluid (CSF) circulation and absorption is blocked, the ventricles dilate, pushing the brain against the skull and compressing cortical veins. This leads to venous congestion and increased intracranial blood volume, further escalating intracranial pressure.…”

Prenatal aqueduct stenosis: Association with rhombencephalosynapsis and neonatal outcome

“…Prior studies have shown an overall mortality of up to 40%, but with survival numbers up to 97% when ventriculomegaly is mild (10‐12 mm) and is the only significant central nervous system anatomic finding . Patients with CAS are at risk for poor neurodevelopmental outcome, particularly when lateral ventriculomegaly measured prenatally is severe (>15 mm) …”

“…4,5 Patients with CAS are at risk for poor neurodevelopmental outcome, particularly when lateral ventriculomegaly measured prenatally is severe (>15 mm). 6,7 Rhombencephalosynapsis (RES) is a malformation of the cerebellum characterized by a missing vermis and fusion of the cerebellar hemispheres. 8 RES has been reported with a frequency of 0.13% in a series evaluating 3000 pediatric MRI studies.…”