Characteristics and Clinical Implications of the Pharmacokinetic Profile of Ibuprofen in Patients with Knee Osteoarthritis

Gallelli, Luca; Galasso, Olimpio; Urzino, A.; Saccà, Salvatore; Falcone, Daniela; Palleria, Caterina; Longo, Pablo G.; Corigliano, A.; Terracciano, Rosa; Savino, Rocco; Gasparini, Giorgio; Sarro, Giovambattista De; Southworth, Stephen R.

doi:10.1007/s40261-012-0011-7

Cited by 26 publications

(19 citation statements)

References 16 publications

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“…Genetic polymorphism of CYP plays an important role in therapeutic effect of drug treatment. 22,23 It signifies that the therapeutic drug monitoring in patients with multiple drug treatment and in vitro techniques can predict the role of CYP enzymes polymorphism, and decrease the occurrence of DDIs. 21 Majority of the interactions involving elimination or excretion process occur due to change in urinary pH, changes in active renal tubule excretion and different drug transporter protein.…”

Section: Resultsmentioning

confidence: 99%

Potential Drug-Drug Interactions among Prescribed Drugs in Paediatric Outpatients Department of a Tertiary Care Teaching Hospital

Mistry¹,

Gor²,

Ganguly³

2017

JYP

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Objective: To evaluate prevalence, types and severity of drug-drug interactions in paediatric outpatient department. Methods: An observational study was carried out in Shree Krishna Hospital (SKH), a tertiary care teaching hospital after obtaining Institutional Ethics Committee approval. In SKH outpatient prescriptions are uploaded on software "Solace" , and these online prescriptions were collected from IT department. Potential Drug-drug interactions (pDDIs) were identified by using Medscape drug interaction checker. The prescriptions were analysed for demographic characteristics, medical and detailed drug history. Drug-drug interactions (DDIs) were evaluated for total numbers, types and severity of DDIs. Result: Total 300 prescriptions with mean age 6.33 ± 5.24 years were analysed. Total 96 pDDIs were recorded. The prevalence of pDDI was 16%. Most common pDDI was Valproic acid + Acetaminophen. There were 61 (63.54%) DDIs of pharmacokinetic, 24 (25%) pharmacodynamic and 11 (11.46%) had an unknown mechanism. Out of all interactions, 41 (42.71%) were of minor, 48 (50%) were of moderate and 07 (7.29%) were of severe in nature. The number of drugs prescribed and the occurrence of DDIs were significantly associated. (p<0.001). This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Section: Resultsmentioning

confidence: 99%

Potential Drug-Drug Interactions among Prescribed Drugs in Paediatric Outpatients Department of a Tertiary Care Teaching Hospital

Mistry¹,

Gor²,

Ganguly³

2017

JYP

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“…Blood testing has been performed in order to analyze the main allelic variants of the CYP450 isoforms CYP2E1, CYP1A2, CYP3A4, CYP2D6, CYP2C9, and CYP2C19 genes. According to previous work, they were identified and analyzed through real‐time polymerase chain reaction by TaqMan kits purchased from Applied Biosystems (Monza, Italy) 27‐29…”

Section: Methodsmentioning

confidence: 99%

Effects of Acetaminophen and Ibuprofen in Children With Migraine Receiving Preventive Treatment With Magnesium

Gallelli¹,

Avenoso²,

Falcone³

et al. 2013

Headache

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“…Both ibuprofen and paracetamol show higher efficacy at higher doses in acute pain (McQuay and Moore, 2007) and probably also in chronic pain, at least for ibuprofen (Gallelli et al, 2012). Typical single oral doses of ibuprofen are between 200 and 400 mg, and for paracetamol between 500 and 1000 mg. We therefore chose to compare these doses in acute pain and headache.…”

Section: Dosesmentioning

confidence: 99%

Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions

Moore

Derry

Wiffen

et al. 2014

European Journal of Pain

102

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Background: Ibuprofen and paracetamol have long been used as analgesics in a range of acute, intermittent and chronic pain conditions. Paracetamol is often the first line analgesic recommended, without consensus about which is the better analgesic. Methods: An overview review of systematic reviews and meta-analyses directly compares ibuprofen and paracetamol at standard doses in particular painful conditions, or uses indirect comparisons against placebo. Electronic searches for systematic reviews were sought published since 1995 using outcomes approximating to ≥50% pain intensity reduction. Painful conditions were acute post-operative pain, dysmenorrhoea, tension-type headache (TTH), migraine, osteoarthritis and rheumatoid arthritis, back pain, cancer and paediatric pain. There was no systematic assessment of harm. Results: Sixteen systematic reviews and four individual patient data meta-analyses were included. Ibuprofen was consistently superior to paracetamol at conventional doses in a range of painful conditions. Two direct comparisons favoured ibuprofen (acute pain, osteoarthritis). Three of four indirect comparisons favoured ibuprofen (acute pain, migraine, osteoarthritis); one showed no difference (TTH), although there were methodological problems. In five pain conditions (dysmenorrhoea, paediatric pain, cancer pain, back pain and rheumatoid arthritis), there were limited data on paracetamol and ibuprofen. Conclusions: At standard doses in different painful conditions, ibuprofen was usually superior producing more patients with the degree of pain relief that patients feel worthwhile. Neither of the drugs will be effective for everyone, and both are needed. This overview questions the practice of routinely using paracetamol as a first line analgesic because there is no good evidence for efficacy of paracetamol in many pain conditions.

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Characteristics and Clinical Implications of the Pharmacokinetic Profile of Ibuprofen in Patients with Knee Osteoarthritis

Abstract: Ibuprofen at higher dosages can be expected to provide better control of OA symptoms as a result of higher tissue distribution.

Cited by 26 publications

References 16 publications

Potential Drug-Drug Interactions among Prescribed Drugs in Paediatric Outpatients Department of a Tertiary Care Teaching Hospital

Potential Drug-Drug Interactions among Prescribed Drugs in Paediatric Outpatients Department of a Tertiary Care Teaching Hospital

Effects of Acetaminophen and Ibuprofen in Children With Migraine Receiving Preventive Treatment With Magnesium

Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions

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