Effects of Acetaminophen and Ibuprofen in Children With Migraine Receiving Preventive Treatment With Magnesium

Gallelli, Luca; Avenoso, Tiziana; Falcone, Daniela; Palleria, Caterina; Peltrone, Francesco; Esposito, Maria; Sarro, Giovambattista De; Carotenuto, Marco; Guidetti, Vincenzo

doi:10.1111/head.12162

Cited by 39 publications

(27 citation statements)

References 42 publications

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“…Students with craniofacial abnormalities or who had already finished their orthodontic treatment and those who were undergoing treatment at the time of the study were excluded. Other exclusion criteria were the following: genetic syndromes,23–26 allergies, endocrinological problems (eg, diabetes), preterm birth,27,28 neurological (eg, epilepsy, primary headaches)29–40 or psychiatric symptoms (attention-deficit/hyperactivity disorder, depression, behavioral problems), mental retardation (intelligence quotient [IQ] ≤70), borderline intellectual functioning (IQ ranging from 71 to 84),41,42 overweight (body mass index ≥85th percentile) or obesity (body mass index ≥95th percentile),43,44 sleep disorders,45–51 primary nocturnal enuresis or encopresis,52–55 and anticonvulsant56–58 or psychoactive drug administration.…”

Section: Methodsmentioning

confidence: 99%

Orthodontic treatment need for adolescents in the Campania region: the malocclusion impact on self-concept

Perillo

Esposito

Caprioglio

et al. 2014

PPA

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BackgroundDental malocclusions can be considered not only as an oral health problem, because they are linked to quality of life perception. Many factors related to malocclusion have strong influences on the perception of facial esthetics (eg, anterior tooth alignment, tooth shape and position, lip thickness, symmetric gingival or tooth contour, lip profile, and overjet). Many reports have shown that the perception of facial esthetics can influence psychological development from early childhood to adulthood. The aim of this study is to investigate the effect of dental malocclusion on self-esteem in a sample of adolescents.Materials and methodsThe study population was composed of 516 orthodontically untreated subjects (256 males) mean ages 13.75±1.977 years recruited from schools in the Campania region of Italy between January 2011 and July 2011. To evaluate the self-esteem grade in our population, all subjects filled out the Multidimensional Self Concept Scale questionnaire and attended an orthodontic clinical evaluation to estimate dental occlusal aspects.ResultsPearson’s analysis shows the relationship in our sample between some occlusal characteristics (crossbite and dental crowding) and aspects of self-concept evaluation (social, competence, academic, physical, and global score) of the Multidimensional Self Concept Scale questionnaire. Moreover, logistic regression analysis shows the potential role of dental crowding (odds ratio 5.359; 95% confidence interval 3.492–8.225) and crossbite (odds ratio 6.153; 95% confidence interval 3.545–10.678) as risk factors for development of global self-concept score abnormalities.ConclusionOur findings confirm the relationship between psychosocial well-being, self-esteem, and dental malocclusion among adolescents.

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Section: Methodsmentioning

confidence: 99%

Orthodontic treatment need for adolescents in the Campania region: the malocclusion impact on self-concept

Perillo

Esposito

Caprioglio

et al. 2014

PPA

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“…In clinical pediatric practice, many alternative therapies, different from the classical pharmacological treatment,15 have been explored, such as weight loss,16 nutraceuticals,17–19 sleep hygiene,20,21 psychotherapy, and generic psychological interventions, and some have shown promise in the treatment of headache symptoms and/or comorbidities in affected children 22–24…”

Section: Introductionmentioning

confidence: 99%

Attachment styles in children affected by migraine without aura

Esposito¹,

Parisi²,

Gallai³

et al. 2013

NDT

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BackgroundIn recent years, great attention has been given to the presence of psychological problems and psychiatric comorbidity that are also present in children affected by primary headaches. The relationship between pain and attachment has been identified, and it may be that pain perception may change in relation with specific attachment styles. The aim of the present study was to assess the prevalent attachment style and verify its putative relationship and correlation with the main characteristics of migraine attacks, in school-aged children affected by migraine without aura (MoA).Materials and methodsThe study population consisted of 219 children (103 males, 116 females) aged between 6 and 11 years (mean 8.96 ± 2.14 years), consecutively referred for MoA compared with 381 healthy controls (174 males, 207 females; mean age 9.01 ± 1.75 years) randomly selected from schools. All the children were classified according to the attachment typologies of the Italian modified version of the Separation Anxiety Test; monthly headache frequency and mean headache duration were assessed from daily headache diaries kept by all the children. Headache intensity was assessed on a visual analog scale. The chi-square test and t-test, where appropriate, were applied, and the Spearman rank correlation test was applied to explore the relationship between the types of attachment style and clinical aspects of MoA.ResultsThe MoA group showed a significantly higher prevalence of type A (avoidant) attachment (P<0.001) and a significantly lower prevalence of type B (secure) attachment (P<0.001) compared with the control group. Moreover, the Spearman rank correlation analysis showed a significant relationship between MoA characteristics and the attachment style of MoA children.ConclusionThe main findings of the present study were the higher prevalence among MoA children of the avoidant attachment style (type A) and the significantly lower prevalence of the secure style attachment (type B) compared with the normal controls, suggesting that the study of psychiatric comorbidity in pediatric headache may be enriched by this new aspect of analysis.

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“…The safety of the study medications was assessed by monitoring the ADRs (eg, renal, gastrointestinal, and liver toxicity as well as allergy) and the drug‐drug interactions, which were assessed for both severity and causality, in agreement with our previous studies …”

Section: Methodsmentioning

confidence: 88%

N‐Palmitoyl Ethanol Amide Pharmacological Treatment in Patients With Nonsurgical Lumbar Radiculopathy

Chirchiglia

Paventi

Seminara³

et al. 2018

The Journal of Clinical Pharma

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Palmitoyl ethanol amide (PEA) is an endogenous substance that plays a role in neuropathic pain. In this article, we evaluated both the safety and the efficacy of ultramicronized PEA (um-PEA) in the treatment of low back pain related to nonsurgical lumbar radiculopathy. In this prospective single-blind study, patients with low back pain related to nonsurgical lumbar radiculopathy received the fixed combination acetaminophen/codeine (500 mg + 30 mg/d) for 7 days, and then it was stopped and changed to um-PEA (1200 mg/d) for 30 days. Patients without an improvement in pain or disability started a second cycle of treatment with um-PEA (600 mg/d in tablets) for 30 days and then acetaminophen/codeine for 30 days. A total of 155 patients were included in the analysis. After the first cycle of treatment we recorded an improvement of pain in all patients with mild pain (visual analog scale score from 3-4 to 1) and in 75% of the patients with moderate pain (visual analog scale score from 5-6 to 2). After the second cycle, we recorded an improvement of pain and disability in all patients with moderate pain (P < .01), but in 26% of patients with severe pain we did not record any improvement in disability (P > .05). In conclusion we evaluated the role of um-PEA in patients with lumbar radiculopathy with a long-term follow-up (24 months) and put in evidence the effectiveness and the safety of this formulation in patients with mild and moderate pain.

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Effects of Acetaminophen and Ibuprofen in Children With Migraine Receiving Preventive Treatment With Magnesium

Abstract: Magnesium increased the efficacy of ibuprofen and acetaminophen with not age-related effects.

Cited by 39 publications

References 42 publications

Orthodontic treatment need for adolescents in the Campania region: the malocclusion impact on self-concept

Orthodontic treatment need for adolescents in the Campania region: the malocclusion impact on self-concept

Attachment styles in children affected by migraine without aura

N‐Palmitoyl Ethanol Amide Pharmacological Treatment in Patients With Nonsurgical Lumbar Radiculopathy

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