Characteristic manifestations of acute paint thinner-intoxicated children

Agin, Khosrow; Hassanian‐Moghaddam, Hossein; Shadnia, Shahin; Rahimi, Hamid Reza

doi:10.1016/j.etap.2016.05.001

Cited by 11 publications

(5 citation statements)

References 6 publications

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“…Reducers are volatile solvents consisting of a mixture of organic compounds like aromatic hydrocarbons, halogenated hydrocarbons and naphtha, toluene, xylene, acetone, hexane, benzene and methyl isobutyl ketone etc. (6)(7)(8).…”

Section: Discussionmentioning

confidence: 99%

Automobile Paint Reducer Induced Acute Kidney Injury

Latief¹,

Hassan²,

Wani³

et al. 2021

jrenhep

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The various aspects of the automobile industry also carry with it the risk for occupational health hazards with it. Toluene has also evolved as a commonly used drug by substance abusers. Accidental exposure or self-poisoning with these substances has been reported in literature. These substances can also cause distal renal tubular acidosis (RTA), acute tubular necrosis, glomerulonephritis and interstitial nephritis, rhabdomyolysis and myoglobinemia.In this series, we report about three patients who developed renal manifestations because of organic solvents. Two of the three patients had ingested the paint reducer substance and the third one was addicted to sniffing the toluene based paint reducer. All the patients had in taken these substances with suicidal intent and developed acute kidney injury (AKI) and severe metabolic acidosis. One of the patients had features of rhabdomyolysis as well. The third patient was a substance abuser and had inhaled higher than usual dose and developed severe and refractory acidosis and mild kidney injury and required Renal Replacement Therapy (RRT) for acidosis. All the patients eventually recovered their kidney functions and were doing well during their follow-up.Toluene based organic solvents lead to acute neurological symptoms, accompanied by severe metabolic alterations, organ injury and dysfunc-tion. An association of the development of hypokalemic paralysis and metabolic acidosis with toluene intoxication has been observed. The management of acute toluene toxicity is mainly conservative, consisting of electrolytes correction, acid-base and fluid abnormalities and renal replacement therapy in severe AKI.Organic solvent exposure may result in acute tubular necrosis, rhabdomyolysis, RTA and AKI irrespective of the intake route. Clinical suspicion of organ dysfunction and failure and timely induction of supportive care leads to a good outcome.

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Section: Discussionmentioning

confidence: 99%

Automobile Paint Reducer Induced Acute Kidney Injury

Latief¹,

Hassan²,

Wani³

et al. 2021

jrenhep

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“…Determining ABG could be used as a powerful prediction marker for poisoning with a toxic substance. [54][55][56] It was indicated that arterial oxygen desaturation was a more sensitive test to evaluate the respiratory effects of longterm and low-dose exposure to PQ spraying among workers. 57 It reported a decline in forced vital capacity and forced expiratory volume in one second, following PQ-applying farmers.…”

Section: Discussionmentioning

confidence: 99%

Delayed death following paraquat poisoning: three case reports and a literature review

Shadnia

Ebadollahi-Natanzi

Ahmadzadeh

et al. 2018

Toxicology Research

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“…Besides, Titanium dioxide and silver are nanoparticles used as paint additives (Smulders et al 2014). All these constituents were reported by many studies to have adverse effects on neurobehavioral, blood, kidney, liver, cardiac, respiratory functions, spleen and many body systems (Chen et al 2001;Ridgway et al 2003;Agin et al 2016). Toxic effects of these materials on the DNA and blood can contribute to their carcinogenicity (Scélo et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

Maksoud

Aal

Ghandour

et al. 2018

Egypt J Forensic Sci

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Background: Occupational exposures to hazardous chemicals in paints cause serious health hazards in painters. The present study was designed to evaluate the possibility of hematotoxic and genotoxic effects of paint chemicals among painters in Assiut Governorate, Egypt. In addition the role of oxidative stress and apoptosis in mechanism of such toxic effects were studied. Methods: A case control study was performed on 50 male painters and 50 non-exposed healthy subjects, who were included as a control group after informed consent. Venous blood samples were obtained and analyzed for determination of total and differential blood count as hematotoxic markers as well as serum malondialdehyde (MDA) as an oxidant stress markers and total antioxidant enzymes. In addition, human B-cell lymphoma-2 (Bcl-2), caspase-3 and 8-hydroxyguanosine (8-OHdG) were assayed as markers of apoptosis and genotoxicity. Results: There was a statistically significant difference between paint workers and controls as regard total and differential blood count, serum MDA and total anti-oxidant levels. Also, statistical significant differences in caspase-3, Bcl-2 levels and 8-OHdG were observed. Conclusions: Chronic occupational exposure to paints increased the risk of hematotoxicity and genotoxicity in painters. Oxidative stress and apoptosis play a major role in such mechanism. Periodic medical examination and application of protective devices is necessary.

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Characteristic manifestations of acute paint thinner-intoxicated children

Cited by 11 publications

References 6 publications

Automobile Paint Reducer Induced Acute Kidney Injury

Automobile Paint Reducer Induced Acute Kidney Injury

Delayed death following paraquat poisoning: three case reports and a literature review

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

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