2018
DOI: 10.1039/c8tx00120k
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Delayed death following paraquat poisoning: three case reports and a literature review

Abstract: Paraquat (PQ) poisoning is the main medical problem in developing countries and it is spread out worldwide. A similar structure of PQ to MPP+ (1-methyl-4-phenylpyridinium) caused PQ-induced neurotoxicity and injury to renal proximal tubules.

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Cited by 26 publications
(26 citation statements)
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“…Paraquat can cause neurological damage and dysfunctional kidneys and liver in humans and animals. In severe cases, fatalities can occur due to irreversible pulmonary fibrosis, inflammation, and respiratory failure (Blanco-Ayala et al, 2014; Shadnia et al, 2018). The paraquat toxicity mechanism is based on redox cycle and intercellular oxidative stress (Dinis-Oliveira et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…Paraquat can cause neurological damage and dysfunctional kidneys and liver in humans and animals. In severe cases, fatalities can occur due to irreversible pulmonary fibrosis, inflammation, and respiratory failure (Blanco-Ayala et al, 2014; Shadnia et al, 2018). The paraquat toxicity mechanism is based on redox cycle and intercellular oxidative stress (Dinis-Oliveira et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…The acute ingestion of 7-8 mL of PQ solution (20% concentration) without treatment can lead to death within a few days. [4,19] Consistent with the clinical manifestations, [20] a large animal lavage model involving doses of PQ above 100 mg/kg can lead to severe poisoning and rapidly affects vital signs within 24 hours. [21] In clinical practice, rapid and accurate detection of PQ levels in plasma and urine samples helps physicians to predict prognosis and choose treatment strategies.…”
Section: Discussionmentioning
confidence: 87%
“…As a result, cases of human deaths from the toxic effects of PQ are not rare [2]. The mechanism of PQ lethal pneumo-and neurotoxicity suggests the accumulation in alveolar cells, neurons, and astroglia and the resulting oxidative stress events.…”
Section: Introductionmentioning
confidence: 99%