Characteristic Changes of Chinese Hamster Cells Surviving Treatment with flavoring agents

Lack of UDS activity in the livers of rats exposed to allylisothiocyanate

“…Similar mixed results have been observed for mutation induction in E. coli [6,7]. Results of tests in cultured mammalian cells show AITC can induce structural and numerical chromosome changes in several cell lines [4,6,[8][9][10][11][12][13][14][15]. In contrast, AITC has given uniformly negative responses in in vivo tests [16][17][18][19][20][21].…”